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Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants
BACKGROUND: Both genetic and environmental factors strongly affect serum uric acid (SUA) concentrations. The incidence of hyperuricemia tends to be younger in the Chinese population. In particular, we have found a high prevalence of hyperuricemia among Chinese flight attendants, aged from 20 to 40,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188807/ https://www.ncbi.nlm.nih.gov/pubmed/35702613 http://dx.doi.org/10.2147/PGPM.S364206 |
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author | Ye, Jianpin Zeng, Zhiwei Chen, Yuxian Wu, Zhenkun Yang, Qingwei Sun, Tao |
author_facet | Ye, Jianpin Zeng, Zhiwei Chen, Yuxian Wu, Zhenkun Yang, Qingwei Sun, Tao |
author_sort | Ye, Jianpin |
collection | PubMed |
description | BACKGROUND: Both genetic and environmental factors strongly affect serum uric acid (SUA) concentrations. The incidence of hyperuricemia tends to be younger in the Chinese population. In particular, we have found a high prevalence of hyperuricemia among Chinese flight attendants, aged from 20 to 40, in our survey. This study aims to evaluate whether there is an association between gene polymorphisms and hyperuricemia among Chinese flight attendants. METHODS: A total of 532 flight attendants with high and normal serum uric acid levels were recruited. Allele-specific polymerase chain reaction (AS-PCR) was performed using blood samples of enrolled subjects. RESULTS: Previous studies have reported single nucleotide polymorphisms (SNPs) that are tightly associated with uric acid levels. Among them, six SNPs that are strongly associated with SUA or gout in Asians, for instance ABCG2 (rs2231142, rs72552713 and rs2231137), GCKR (rs780094), SLC2A9 (rs1014290) and SLC17A1 (rs1183201), were selected for AS-PCR analyses. We found that SNPs such as ABCG2 rs2231142, GCKR rs780094 and SLC2A9 rs1014290 are strongly associated with hyperuricemia in male flight attendants, and SLC2A9 rs1014290 among female flight attendants. CONCLUSION: Our study provides evidences of an association between SNPs and hyperuricemia in the Chinese flight attendants, and highlights the significance of improving diagnostics and prevention of disease development in uric acid metabolism disorders and gout using these SNPs. |
format | Online Article Text |
id | pubmed-9188807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-91888072022-06-13 Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants Ye, Jianpin Zeng, Zhiwei Chen, Yuxian Wu, Zhenkun Yang, Qingwei Sun, Tao Pharmgenomics Pers Med Original Research BACKGROUND: Both genetic and environmental factors strongly affect serum uric acid (SUA) concentrations. The incidence of hyperuricemia tends to be younger in the Chinese population. In particular, we have found a high prevalence of hyperuricemia among Chinese flight attendants, aged from 20 to 40, in our survey. This study aims to evaluate whether there is an association between gene polymorphisms and hyperuricemia among Chinese flight attendants. METHODS: A total of 532 flight attendants with high and normal serum uric acid levels were recruited. Allele-specific polymerase chain reaction (AS-PCR) was performed using blood samples of enrolled subjects. RESULTS: Previous studies have reported single nucleotide polymorphisms (SNPs) that are tightly associated with uric acid levels. Among them, six SNPs that are strongly associated with SUA or gout in Asians, for instance ABCG2 (rs2231142, rs72552713 and rs2231137), GCKR (rs780094), SLC2A9 (rs1014290) and SLC17A1 (rs1183201), were selected for AS-PCR analyses. We found that SNPs such as ABCG2 rs2231142, GCKR rs780094 and SLC2A9 rs1014290 are strongly associated with hyperuricemia in male flight attendants, and SLC2A9 rs1014290 among female flight attendants. CONCLUSION: Our study provides evidences of an association between SNPs and hyperuricemia in the Chinese flight attendants, and highlights the significance of improving diagnostics and prevention of disease development in uric acid metabolism disorders and gout using these SNPs. Dove 2022-06-08 /pmc/articles/PMC9188807/ /pubmed/35702613 http://dx.doi.org/10.2147/PGPM.S364206 Text en © 2022 Ye et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Ye, Jianpin Zeng, Zhiwei Chen, Yuxian Wu, Zhenkun Yang, Qingwei Sun, Tao Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants |
title | Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants |
title_full | Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants |
title_fullStr | Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants |
title_full_unstemmed | Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants |
title_short | Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants |
title_sort | examining an association of single nucleotide polymorphisms with hyperuricemia in chinese flight attendants |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188807/ https://www.ncbi.nlm.nih.gov/pubmed/35702613 http://dx.doi.org/10.2147/PGPM.S364206 |
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