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Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study

BACKGROUND: Evidence suggests that there is some relationship between circadian clock gene variants and obesity. However, there are few examinations supporting this observation in human subjects. This study was aimed to investigate the interaction between Cry1 circadian gene polymorphism and major d...

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Autores principales: Tangestani, Hadith, Emamat, Hadi, Yekaninejad, Mir Saeed, Alipour, Mohsen, Keshavarz, Seyed Ali, Mirzaei, Khadijeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188878/
https://www.ncbi.nlm.nih.gov/pubmed/35706856
http://dx.doi.org/10.4103/ijpvm.IJPVM_352_20
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author Tangestani, Hadith
Emamat, Hadi
Yekaninejad, Mir Saeed
Alipour, Mohsen
Keshavarz, Seyed Ali
Mirzaei, Khadijeh
author_facet Tangestani, Hadith
Emamat, Hadi
Yekaninejad, Mir Saeed
Alipour, Mohsen
Keshavarz, Seyed Ali
Mirzaei, Khadijeh
author_sort Tangestani, Hadith
collection PubMed
description BACKGROUND: Evidence suggests that there is some relationship between circadian clock gene variants and obesity. However, there are few examinations supporting this observation in human subjects. This study was aimed to investigate the interaction between Cry1 circadian gene polymorphism and major dietary patterns on obesity measurements. METHODS: Healthy overweight and obese women aged 18–53 years old were recruited from health centers in Tehran, Iran by a multistage cluster random sampling method (n = 377). Major dietary patterns were elicited after assessing the intake of 16 food groups using a valid and reliable 147-item food frequency questionnaire (FFQ). Anthropometric measurements were performed for each and every participant. Body composition was analyzed using bioelectrical impedance analysis (BIA). Socio-demographic and physical activity data were also collected by a validated Farsi demographic questionnaire and the international physical activity questionnaire (IPAQ). The Cry1 rs2287161 polymorphism were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Generalized linear models were used for interaction analysis. RESULTS: Two major dietary patterns, including healthy and unhealthy dietary pattern (HDP and UDP, respectively) were determined using factor analysis. Our study showed a significant higher weight (P = 0.003), body mass index (BMI) (P = 0.042), hip circumference (P = 0.052), and body fat mass (P = 0.028) in carriers of C allele compared with G allele. Moreover, a significant gene-diet interaction was observed between being a carrier of C allele and BMI (P = 0.099 for CC genotype; P = 0.1 for CG genotype) and fat mass (P = 0.1 for CG genotype). CONCLUSIONS: The current study suggests a significant interaction of Cry1 rs2287161 gene polymorphisms in people following a healthy dietary pattern on BMI and fat mass among carriers of C allele compared to carriers of G allele.
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spelling pubmed-91888782022-06-14 Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study Tangestani, Hadith Emamat, Hadi Yekaninejad, Mir Saeed Alipour, Mohsen Keshavarz, Seyed Ali Mirzaei, Khadijeh Int J Prev Med Original Article BACKGROUND: Evidence suggests that there is some relationship between circadian clock gene variants and obesity. However, there are few examinations supporting this observation in human subjects. This study was aimed to investigate the interaction between Cry1 circadian gene polymorphism and major dietary patterns on obesity measurements. METHODS: Healthy overweight and obese women aged 18–53 years old were recruited from health centers in Tehran, Iran by a multistage cluster random sampling method (n = 377). Major dietary patterns were elicited after assessing the intake of 16 food groups using a valid and reliable 147-item food frequency questionnaire (FFQ). Anthropometric measurements were performed for each and every participant. Body composition was analyzed using bioelectrical impedance analysis (BIA). Socio-demographic and physical activity data were also collected by a validated Farsi demographic questionnaire and the international physical activity questionnaire (IPAQ). The Cry1 rs2287161 polymorphism were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Generalized linear models were used for interaction analysis. RESULTS: Two major dietary patterns, including healthy and unhealthy dietary pattern (HDP and UDP, respectively) were determined using factor analysis. Our study showed a significant higher weight (P = 0.003), body mass index (BMI) (P = 0.042), hip circumference (P = 0.052), and body fat mass (P = 0.028) in carriers of C allele compared with G allele. Moreover, a significant gene-diet interaction was observed between being a carrier of C allele and BMI (P = 0.099 for CC genotype; P = 0.1 for CG genotype) and fat mass (P = 0.1 for CG genotype). CONCLUSIONS: The current study suggests a significant interaction of Cry1 rs2287161 gene polymorphisms in people following a healthy dietary pattern on BMI and fat mass among carriers of C allele compared to carriers of G allele. Wolters Kluwer - Medknow 2022-04-05 /pmc/articles/PMC9188878/ /pubmed/35706856 http://dx.doi.org/10.4103/ijpvm.IJPVM_352_20 Text en Copyright: © 2022 International Journal of Preventive Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Tangestani, Hadith
Emamat, Hadi
Yekaninejad, Mir Saeed
Alipour, Mohsen
Keshavarz, Seyed Ali
Mirzaei, Khadijeh
Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study
title Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study
title_full Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study
title_fullStr Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study
title_full_unstemmed Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study
title_short Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity: A Cross-Sectional Study
title_sort interaction of cry1 gene polymorphisms and dominant food patterns on obesity: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188878/
https://www.ncbi.nlm.nih.gov/pubmed/35706856
http://dx.doi.org/10.4103/ijpvm.IJPVM_352_20
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