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The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study

BACKGROUND: There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA patients with healthy controls. METHODS: 39 FDR (...

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Autores principales: Amra, Babak, Shafiei, Amin, Soltaninejad, Forogh, Asgari, Abdollah, Farajzadegan, Ziba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188903/
https://www.ncbi.nlm.nih.gov/pubmed/35706864
http://dx.doi.org/10.4103/ijpvm.IJPVM_602_20
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author Amra, Babak
Shafiei, Amin
Soltaninejad, Forogh
Asgari, Abdollah
Farajzadegan, Ziba
author_facet Amra, Babak
Shafiei, Amin
Soltaninejad, Forogh
Asgari, Abdollah
Farajzadegan, Ziba
author_sort Amra, Babak
collection PubMed
description BACKGROUND: There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA patients with healthy controls. METHODS: 39 FDR (parents, siblings, and children) of patients diagnosed with OSA at Bamdad Respiratory and Research Center as cases and age- and sex-matched healthy controls were included in the current case–control pilot study. The sampling method was convenience sampling based on having inclusion criteria and consent to participate in the study. Demographic characteristics and essential criteria for diagnosing MS included blood pressure, anthropometric [weight (kg), height (cm), waist circumference (cm) and body mass index (BMI) (kg/m(2))], and biochemical indices (lipid profile and blood glucose) were assessed based on standard protocols. RESULTS: In the comparison of the demographic and clinical characteristics of two39 cases and control groups, weight and diastolic blood pressure were significantly higher in case group than controls (P < 0.05). Case and control groups were not significantly different in the frequency of MS (P > 0.05). Although, the frequency of hypertension as an important cardiovascular risk factor was higher in cases than controls (P < 0.05). CONCLUSIONS: The present study demonstrates that the frequency of MS is not significantly different between FDRs of OSA patients and controls. However, further large-scale studies are warranted to detect the frequency of MS in people with hereditary background for OSA compared to general population.
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spelling pubmed-91889032022-06-14 The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study Amra, Babak Shafiei, Amin Soltaninejad, Forogh Asgari, Abdollah Farajzadegan, Ziba Int J Prev Med Original Article BACKGROUND: There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA patients with healthy controls. METHODS: 39 FDR (parents, siblings, and children) of patients diagnosed with OSA at Bamdad Respiratory and Research Center as cases and age- and sex-matched healthy controls were included in the current case–control pilot study. The sampling method was convenience sampling based on having inclusion criteria and consent to participate in the study. Demographic characteristics and essential criteria for diagnosing MS included blood pressure, anthropometric [weight (kg), height (cm), waist circumference (cm) and body mass index (BMI) (kg/m(2))], and biochemical indices (lipid profile and blood glucose) were assessed based on standard protocols. RESULTS: In the comparison of the demographic and clinical characteristics of two39 cases and control groups, weight and diastolic blood pressure were significantly higher in case group than controls (P < 0.05). Case and control groups were not significantly different in the frequency of MS (P > 0.05). Although, the frequency of hypertension as an important cardiovascular risk factor was higher in cases than controls (P < 0.05). CONCLUSIONS: The present study demonstrates that the frequency of MS is not significantly different between FDRs of OSA patients and controls. However, further large-scale studies are warranted to detect the frequency of MS in people with hereditary background for OSA compared to general population. Wolters Kluwer - Medknow 2022-04-27 /pmc/articles/PMC9188903/ /pubmed/35706864 http://dx.doi.org/10.4103/ijpvm.IJPVM_602_20 Text en Copyright: © 2022 International Journal of Preventive Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Amra, Babak
Shafiei, Amin
Soltaninejad, Forogh
Asgari, Abdollah
Farajzadegan, Ziba
The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study
title The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study
title_full The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study
title_fullStr The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study
title_full_unstemmed The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study
title_short The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case–Control Study
title_sort prevalence of metabolic syndrome in first degree relatives of patients with obstructive sleep apnea syndrome: a case–control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188903/
https://www.ncbi.nlm.nih.gov/pubmed/35706864
http://dx.doi.org/10.4103/ijpvm.IJPVM_602_20
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