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Deceased donor liver transplantation under the Korean model for end-stage liver disease score-based liver allocation system: 2-year allocation results at a high-volume transplantation center

BACKGROUND: The Korean model for end-stage liver disease (MELD) score-based liver allocation system was started in June 2016 in Korea. METHODS: This study analyzed the detailed allocation results of deceased donor liver transplantation (DDLT) during the first 2 years after the MELD score-based liver...

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Detalles Bibliográficos
Autores principales: Ha, Hea-Seon, Hong, Jung-Ja, Kim, In-Ok, Lee, Sae-Rom, Lee, Ah-Young, Ha, Tae-Yong, Song, Gi-Won, Jung, Dong-Hwan, Park, Gil-Chun, Ahn, Chul-Soo, Moon, Deok-Bog, Kim, Ki-Hun, Lee, Sung-Gyu, Hwang, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Transplantation 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188943/
https://www.ncbi.nlm.nih.gov/pubmed/35769978
http://dx.doi.org/10.4285/jkstn.2019.33.4.112
Descripción
Sumario:BACKGROUND: The Korean model for end-stage liver disease (MELD) score-based liver allocation system was started in June 2016 in Korea. METHODS: This study analyzed the detailed allocation results of deceased donor liver transplantation (DDLT) during the first 2 years after the MELD score-based liver allocation system implementation at a high-volume liver transplantation (LT) center in Korea. RESULTS: This study included 174 patients with age above 12 years. The patient ABO blood groups were A (n=65, 37.4%), B (n=51, 29.3%), O (n=28, 16.1%), and AB (n=30, 17.2%). The LT types were primary LT in 141 patients (81.0%) and retransplantation in 33 (19.0%). The Korean Network for Organ Sharing status categories at LT were as follows: status 1 (n=11, 6.3%), status 2 (n=82, 47.1%), status 3 (n=63, 36.2%), and status 4 (n=18, 10.3%). The mean MELD score at LT and waiting period were 36.6±4.6 and 62.1±98.2 days in blood group A; 37.6±3.6 and 25.7±38.1 days in blood group B; 38.8±2.7 and 26.0±30.5 days in blood group O; and 34.8±5.5 and 68.4±110.5 days in blood group AB (P<0.001 and P=0.012), respectively. Patients with blood group O and AB had the highest and lowest mean MELD scores at LT allocation, respectively. CONCLUSIONS: Serious deceased organ donor shortage resulted in very high MELD score cutoffs for DDLT allocation. Additionally, a significant inequality was observed in the possibility for DDLT according to blood group compatibility. Nationwide follow-up studies are necessary to precisely determine the allocation status of DDLT.