Monocarboxylate transporter 1 deficiency impacts CD8(+) T lymphocytes proliferation and recruitment to adipose tissue during obesity

Lactate sits at the crossroad of metabolism, immunity, and inflammation. The expression of cellular lactate transporter MCT1 (known as Slc16a1) increases during immune cell activation to cope with the metabolic reprogramming. We investigated the impact of MCT1 deficiency on CD8(+) T cell function du...

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Detalles Bibliográficos
Autores principales: Macchi, C., Moregola, A., Greco, M.F., Svecla, M., Bonacina, F., Dhup, S., Dadhich, R.K., Audano, M., Sonveaux, P., Mauro, C., Mitro, N., Ruscica, M., Norata, G.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189020/
https://www.ncbi.nlm.nih.gov/pubmed/35707720
http://dx.doi.org/10.1016/j.isci.2022.104435

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