Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we identify metabolic engineering targets limiting expression of recombinant human proteins through a systems biology analysis of the transcriptomes of CHO...

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Detalles Bibliográficos
Autores principales: Malm, Magdalena, Kuo, Chih-Chung, Barzadd, Mona Moradi, Mebrahtu, Aman, Wistbacka, Num, Razavi, Ronia, Volk, Anna-Luisa, Lundqvist, Magnus, Kotol, David, Tegel, Hanna, Hober, Sophia, Edfors, Fredrik, Gräslund, Torbjörn, Chotteau, Veronique, Field, Ray, Varley, Paul G., Roth, Robert G., Lewis, Nathan E., Hatton, Diane, Rockberg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189052/
https://www.ncbi.nlm.nih.gov/pubmed/35301123
http://dx.doi.org/10.1016/j.ymben.2022.03.009

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