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Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathology

The apolipoprotein E4 (APOE4) genotype is one of the strongest genetic risk factors for Alzheimer’s disease (AD), and is generally believed to cause widespread pathological alterations in various types of brain cells. Here, we developed a novel engineering method of creating the chimeric human cereb...

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Detalles Bibliográficos
Autores principales:	Huang, Shichao, Zhang, Zhen, Cao, Junwei, Yu, Yongchun, Pei, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189105/ https://www.ncbi.nlm.nih.gov/pubmed/35691989 http://dx.doi.org/10.1038/s41392-022-01006-x

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