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Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen
Spacing of BNT162b2 mRNA doses beyond 3 weeks raises concerns about vaccine efficacy. We longitudinally analyze B cell, T cell, and humoral responses to two BNT162b2 mRNA doses administered 16 weeks apart in 53 SARS-CoV-2 naive and previously infected donors. This regimen elicits robust RBD-specific...
Autores principales: | Nayrac, Manon, Dubé, Mathieu, Sannier, Gérémy, Nicolas, Alexandre, Marchitto, Lorie, Tastet, Olivier, Tauzin, Alexandra, Brassard, Nathalie, Lima-Barbosa, Raphaël, Beaudoin-Bussières, Guillaume, Vézina, Dani, Gong, Shang Yu, Benlarbi, Mehdi, Gasser, Romain, Laumaea, Annemarie, Prévost, Jérémie, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Goyette, Guillaume, Ortega-Delgado, Gloria-Gabrielle, Laporte, Mélanie, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Richard, Jonathan, Bélair, Justin, Prat, Alexandre, Tremblay, Cécile, Martel-Laferrière, Valérie, Finzi, Andrés, Kaufmann, Daniel E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s).
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189142/ https://www.ncbi.nlm.nih.gov/pubmed/35732172 http://dx.doi.org/10.1016/j.celrep.2022.111013 |
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