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SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature
Bacterial co-pathogens are commonly identified in viral respiratory infections and are important causes of morbid-mortality. The prevalence of Chlamydia (C.) pneumoniae infection in patients infected with SARS-CoV-2 has not been sufficiently studied. The objective of the present review was to descri...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asociación Argentina de Microbiología. Published by Elsevier España, S.L.U.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189145/ https://www.ncbi.nlm.nih.gov/pubmed/35931565 http://dx.doi.org/10.1016/j.ram.2022.05.009 |
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author | Frutos, María Celia Origlia, Javier Gallo Vaulet, María Lucia Venuta, María Elena García, Miriam Gabriela Armitano, Rita Cipolla, Lucía Madariaga, María Julia Cuffini, Cecilia Cadario, María Estela |
author_facet | Frutos, María Celia Origlia, Javier Gallo Vaulet, María Lucia Venuta, María Elena García, Miriam Gabriela Armitano, Rita Cipolla, Lucía Madariaga, María Julia Cuffini, Cecilia Cadario, María Estela |
author_sort | Frutos, María Celia |
collection | PubMed |
description | Bacterial co-pathogens are commonly identified in viral respiratory infections and are important causes of morbid-mortality. The prevalence of Chlamydia (C.) pneumoniae infection in patients infected with SARS-CoV-2 has not been sufficiently studied. The objective of the present review was to describe the prevalence of C. pneumoniae in patients with coronavirus disease 2019 (COVID-19). A search in MEDLINE and Google Scholar databases for English language literature published between January 2020 and August 2021 was performed. Studies evaluating patients with confirmed COVID-19 and reporting the simultaneous detection of C. pneumoniae were included. Eleven articles were included in the systematic review (5 case cross-sectional studies and 6 retrospective studies). A total of 18 450 patients were included in the eleven studies. The detection of laboratory-confirmed C. pneumoniae infection varied between 1.78 and 71.4% of the total number of co-infections. The median age of patients ranged from 35 to 71 years old and 65% were male. Most of the studies reported one or more pre-existing comorbidities and the majority of the patients presented with fever, cough and dyspnea. Lymphopenia and eosinopenia were described in COVID-19 co-infected patients. The main chest CT scan showed a ground glass density shadow, consolidation and bilateral pneumonia. Most patients received empirical antibiotics. Bacterial co-infection was not associated with increased ICU admission and mortality. Despite frequent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus 2-associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial co-infection. Prospective evidence generation to support the development of an antimicrobial policy and appropriate stewardship interventions specific for the COVID-19 pandemic are urgently required. |
format | Online Article Text |
id | pubmed-9189145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Asociación Argentina de Microbiología. Published by Elsevier España, S.L.U. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91891452022-06-13 SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature Frutos, María Celia Origlia, Javier Gallo Vaulet, María Lucia Venuta, María Elena García, Miriam Gabriela Armitano, Rita Cipolla, Lucía Madariaga, María Julia Cuffini, Cecilia Cadario, María Estela Rev Argent Microbiol Special Article Bacterial co-pathogens are commonly identified in viral respiratory infections and are important causes of morbid-mortality. The prevalence of Chlamydia (C.) pneumoniae infection in patients infected with SARS-CoV-2 has not been sufficiently studied. The objective of the present review was to describe the prevalence of C. pneumoniae in patients with coronavirus disease 2019 (COVID-19). A search in MEDLINE and Google Scholar databases for English language literature published between January 2020 and August 2021 was performed. Studies evaluating patients with confirmed COVID-19 and reporting the simultaneous detection of C. pneumoniae were included. Eleven articles were included in the systematic review (5 case cross-sectional studies and 6 retrospective studies). A total of 18 450 patients were included in the eleven studies. The detection of laboratory-confirmed C. pneumoniae infection varied between 1.78 and 71.4% of the total number of co-infections. The median age of patients ranged from 35 to 71 years old and 65% were male. Most of the studies reported one or more pre-existing comorbidities and the majority of the patients presented with fever, cough and dyspnea. Lymphopenia and eosinopenia were described in COVID-19 co-infected patients. The main chest CT scan showed a ground glass density shadow, consolidation and bilateral pneumonia. Most patients received empirical antibiotics. Bacterial co-infection was not associated with increased ICU admission and mortality. Despite frequent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus 2-associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial co-infection. Prospective evidence generation to support the development of an antimicrobial policy and appropriate stewardship interventions specific for the COVID-19 pandemic are urgently required. Asociación Argentina de Microbiología. Published by Elsevier España, S.L.U. 2022 2022-06-13 /pmc/articles/PMC9189145/ /pubmed/35931565 http://dx.doi.org/10.1016/j.ram.2022.05.009 Text en © 2022 Asociación Argentina de Microbiología. Published by Elsevier España, S.L.U. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Special Article Frutos, María Celia Origlia, Javier Gallo Vaulet, María Lucia Venuta, María Elena García, Miriam Gabriela Armitano, Rita Cipolla, Lucía Madariaga, María Julia Cuffini, Cecilia Cadario, María Estela SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature |
title | SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature |
title_full | SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature |
title_fullStr | SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature |
title_full_unstemmed | SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature |
title_short | SARS-CoV-2 and Chlamydia pneumoniae co-infection: A review of the literature |
title_sort | sars-cov-2 and chlamydia pneumoniae co-infection: a review of the literature |
topic | Special Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189145/ https://www.ncbi.nlm.nih.gov/pubmed/35931565 http://dx.doi.org/10.1016/j.ram.2022.05.009 |
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