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Expression, purification, and kinetic characterization of the human strep-IDO1

BACKGROUND: Tryptophan catabolism leading to T cell suppression mediated by indoleamine 2,3-dioxygenase (IDO1) is an important mechanism of tumor immune escape, and IDO1 inhibitors have attracted increasing attention as anticancer therapeutics. However, the phase III clinical trial (ECHO-301/KEYNOTE...

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Detalles Bibliográficos
Autores principales:	Saimi, Dilizhatai, Wang, Zhenfeng, Zhu, Qiangqiang, Lv, Jiadi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189243/ https://www.ncbi.nlm.nih.gov/pubmed/35706807 http://dx.doi.org/10.21037/tcr-21-2518

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