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Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy

Liver transplantation (LT) for patients with non-resectable colorectal liver metastases (CRLM) offers improved survival and has gained increased interest internationally the last years. The aim of this study was to describe the health-related quality of life (HRQoL) in patients with non-resectable C...

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Autores principales: Smedman, Tor Magnus, Guren, Tormod Kyrre, Tveit, Kjell Magne, Thomsen, Maria, Andersen, Marit Helen, Line, Pål-Dag, Dueland, Svein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189292/
https://www.ncbi.nlm.nih.gov/pubmed/35707633
http://dx.doi.org/10.3389/ti.2022.10404
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author Smedman, Tor Magnus
Guren, Tormod Kyrre
Tveit, Kjell Magne
Thomsen, Maria
Andersen, Marit Helen
Line, Pål-Dag
Dueland, Svein
author_facet Smedman, Tor Magnus
Guren, Tormod Kyrre
Tveit, Kjell Magne
Thomsen, Maria
Andersen, Marit Helen
Line, Pål-Dag
Dueland, Svein
author_sort Smedman, Tor Magnus
collection PubMed
description Liver transplantation (LT) for patients with non-resectable colorectal liver metastases (CRLM) offers improved survival and has gained increased interest internationally the last years. The aim of this study was to describe the health-related quality of life (HRQoL) in patients with non-resectable CRLM receiving LT and how baseline HRQoL factors affect overall survival (OS). HRQoL data in the SECA (SEcondary CAncer) LT cohort was compared to data obtained from colorectal cancer patients starting first-line chemotherapy for metastatic disease in a clinical trial and data from a Norwegian normal population. HRQoL data from the QLQ-C30 questionnaire used in the SECA LT study and the NORDIC- VII study were reported. The relationship between patient-reported symptom burden at baseline and OS was investigated. In the SECA study longitudinal HRQoL assessment was used to describe the time until definitive deterioration as well as mean values at different time points. Patients in the SECA and NORDIC-VII studies reported similar baseline HRQoL. The median time until definitive deterioration in the transplanted patients was estimated to 36 months. In the SECA study appetite loss and pain at baseline had negative impact on OS (25.3 versus 71.7 months, p = 0.002 and 39.7 versus 71.7 months, p = 0.038, respectively). Despite a relapse in most of the LT patients the Global Health Score (GHS) remained good. Pain, and especially appetite loss at time of transplantation is associated with poor outcome after LT.
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spelling pubmed-91892922022-06-14 Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy Smedman, Tor Magnus Guren, Tormod Kyrre Tveit, Kjell Magne Thomsen, Maria Andersen, Marit Helen Line, Pål-Dag Dueland, Svein Transpl Int Health Archive Liver transplantation (LT) for patients with non-resectable colorectal liver metastases (CRLM) offers improved survival and has gained increased interest internationally the last years. The aim of this study was to describe the health-related quality of life (HRQoL) in patients with non-resectable CRLM receiving LT and how baseline HRQoL factors affect overall survival (OS). HRQoL data in the SECA (SEcondary CAncer) LT cohort was compared to data obtained from colorectal cancer patients starting first-line chemotherapy for metastatic disease in a clinical trial and data from a Norwegian normal population. HRQoL data from the QLQ-C30 questionnaire used in the SECA LT study and the NORDIC- VII study were reported. The relationship between patient-reported symptom burden at baseline and OS was investigated. In the SECA study longitudinal HRQoL assessment was used to describe the time until definitive deterioration as well as mean values at different time points. Patients in the SECA and NORDIC-VII studies reported similar baseline HRQoL. The median time until definitive deterioration in the transplanted patients was estimated to 36 months. In the SECA study appetite loss and pain at baseline had negative impact on OS (25.3 versus 71.7 months, p = 0.002 and 39.7 versus 71.7 months, p = 0.038, respectively). Despite a relapse in most of the LT patients the Global Health Score (GHS) remained good. Pain, and especially appetite loss at time of transplantation is associated with poor outcome after LT. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9189292/ /pubmed/35707633 http://dx.doi.org/10.3389/ti.2022.10404 Text en Copyright © 2022 Smedman, Guren, Tveit, Thomsen, Andersen, Line and Dueland. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Smedman, Tor Magnus
Guren, Tormod Kyrre
Tveit, Kjell Magne
Thomsen, Maria
Andersen, Marit Helen
Line, Pål-Dag
Dueland, Svein
Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
title Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
title_full Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
title_fullStr Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
title_full_unstemmed Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
title_short Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
title_sort health-related quality of life in colorectal cancer patients treated with liver transplantation compared to chemotherapy
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189292/
https://www.ncbi.nlm.nih.gov/pubmed/35707633
http://dx.doi.org/10.3389/ti.2022.10404
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