Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy

N(6)-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases (“writers”) and demethylases (“erasers”) and is recognized and processed by m(6)A-binding proteins (“readers”), which further regulate RNA tr...

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Autores principales: Zhu, Yong-fu, Wang, Shu-Jie, Zhou, Jie, Sun, Ye-han, Chen, You-mou, Ma, Jia, Huo, Xing-xing, Song, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189310/
https://www.ncbi.nlm.nih.gov/pubmed/35707365
http://dx.doi.org/10.3389/fonc.2022.897895
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author Zhu, Yong-fu
Wang, Shu-Jie
Zhou, Jie
Sun, Ye-han
Chen, You-mou
Ma, Jia
Huo, Xing-xing
Song, Hang
author_facet Zhu, Yong-fu
Wang, Shu-Jie
Zhou, Jie
Sun, Ye-han
Chen, You-mou
Ma, Jia
Huo, Xing-xing
Song, Hang
author_sort Zhu, Yong-fu
collection PubMed
description N(6)-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases (“writers”) and demethylases (“erasers”) and is recognized and processed by m(6)A-binding proteins (“readers”), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m(6)A and coding and non-coding RNAs and introduce the molecular mechanism of m(6)A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example.
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spelling pubmed-91893102022-06-14 Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy Zhu, Yong-fu Wang, Shu-Jie Zhou, Jie Sun, Ye-han Chen, You-mou Ma, Jia Huo, Xing-xing Song, Hang Front Oncol Oncology N(6)-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases (“writers”) and demethylases (“erasers”) and is recognized and processed by m(6)A-binding proteins (“readers”), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m(6)A and coding and non-coding RNAs and introduce the molecular mechanism of m(6)A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9189310/ /pubmed/35707365 http://dx.doi.org/10.3389/fonc.2022.897895 Text en Copyright © 2022 Zhu, Wang, Zhou, Sun, Chen, Ma, Huo and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhu, Yong-fu
Wang, Shu-Jie
Zhou, Jie
Sun, Ye-han
Chen, You-mou
Ma, Jia
Huo, Xing-xing
Song, Hang
Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
title Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
title_full Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
title_fullStr Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
title_full_unstemmed Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
title_short Effects of N(6)-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
title_sort effects of n(6)-methyladenosine modification on cancer progression: molecular mechanisms and cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189310/
https://www.ncbi.nlm.nih.gov/pubmed/35707365
http://dx.doi.org/10.3389/fonc.2022.897895
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