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Epigallocatechin Gallate Induces the Demethylation of Actinin Alpha 4 to Inhibit Diabetic Nephropathy Renal Fibrosis via the NF-KB Signaling Pathway In Vitro

Actinin alpha 4 (ACTN4) is expressed in the kidney podocytes. ACTN4 gene methylation in patients with diabetic nephropathy (DN) remains high. Underlying mechanism of epigallocatechin-3-gallate (EGCG) inducing ACTN4 demethylation, and its inhibitory effect on DN renal fibrosis remains unclear. METHOD...

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Detalles Bibliográficos
Autores principales:	He, Chunling, Wang, Dong, Wang, Ruoling, Huang, Yongli, Huang, Xin, Shen, ShuMin, Lv, Jun, Wu, Mingcai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189538/ https://www.ncbi.nlm.nih.gov/pubmed/35706474 http://dx.doi.org/10.1177/15593258221105704

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