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Polyglutamic Acid‐Based Elastic and Tough Adhesive Patch Promotes Tissue Regeneration through In Situ Macrophage Modulation

Adhesive patches are advanced but challenging alternatives to suture, especially in treating fragile internal organs. So far there is no suture‐free adhesive patch based on metabolizable poly(amino acid) materials with excellent mechanical strength as well as immunomodulation functionality. Here, a...

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Detalles Bibliográficos
Autores principales: Zhu, Qiuwen, Hong, Yi, Huang, Yuxuan, Zhang, Yi, Xie, Chang, Liang, Renjie, Li, Chenglin, Zhang, Tao, Wu, Hongwei, Ye, Jinchun, Zhang, Xianzhu, Zhang, Shufang, Zou, Xiaohui, Ouyang, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189670/
https://www.ncbi.nlm.nih.gov/pubmed/35396785
http://dx.doi.org/10.1002/advs.202106115
Descripción
Sumario:Adhesive patches are advanced but challenging alternatives to suture, especially in treating fragile internal organs. So far there is no suture‐free adhesive patch based on metabolizable poly(amino acid) materials with excellent mechanical strength as well as immunomodulation functionality. Here, a polyglutamic acid‐based elastic and tough adhesive patch modified by photosensitive groups on the surface to achieve robust light‐activated adhesion and sealing of flexible internal organs is explored. With the porous internal morphology and excellent biodegradability, the patches promote regeneration through a macrophage‐regulating microenvironment. Treated rabbits achieve rapid full‐thickness gastric regeneration with complete functional structure within 14 d, suggesting its robust tissue adhesion and repair‐promoting ability.