Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Combining single‐cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an ERK biosensor to measure single‐cell ERK dynamics. This allowed us to conduct RNA...

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Detalles Bibliográficos
Autores principales: Dessauges, Coralie, Mikelson, Jan, Dobrzyński, Maciej, Jacques, Marc‐Antoine, Frismantiene, Agne, Gagliardi, Paolo Armando, Khammash, Mustafa, Pertz, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189677/
https://www.ncbi.nlm.nih.gov/pubmed/35694820
http://dx.doi.org/10.15252/msb.202110670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189677/
https://www.ncbi.nlm.nih.gov/pubmed/35694820
http://dx.doi.org/10.15252/msb.202110670

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