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Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors
Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15–20% of children and 3–5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermati...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Publication of Acta Dermato-Venereologica
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189753/ https://www.ncbi.nlm.nih.gov/pubmed/32412642 http://dx.doi.org/10.2340/00015555-3512 |
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author | THYSSEN, Jacob P. RINNOV, Maria Rasmussen VESTERGAARD, Christian |
author_facet | THYSSEN, Jacob P. RINNOV, Maria Rasmussen VESTERGAARD, Christian |
author_sort | THYSSEN, Jacob P. |
collection | PubMed |
description | Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15–20% of children and 3–5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease. |
format | Online Article Text |
id | pubmed-9189753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-91897532022-10-20 Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors THYSSEN, Jacob P. RINNOV, Maria Rasmussen VESTERGAARD, Christian Acta Derm Venereol Review Article Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15–20% of children and 3–5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease. Society for Publication of Acta Dermato-Venereologica 2020-06-09 /pmc/articles/PMC9189753/ /pubmed/32412642 http://dx.doi.org/10.2340/00015555-3512 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Review Article THYSSEN, Jacob P. RINNOV, Maria Rasmussen VESTERGAARD, Christian Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors |
title | Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors |
title_full | Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors |
title_fullStr | Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors |
title_full_unstemmed | Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors |
title_short | Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors |
title_sort | disease mechanisms in atopic dermatitis: a review of aetiological factors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189753/ https://www.ncbi.nlm.nih.gov/pubmed/32412642 http://dx.doi.org/10.2340/00015555-3512 |
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