Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature

A simple and practical strategy for intermolecular aminohalogenation of quinone with alkyl amines and NXS was developed, in which haloamines generated in situ were employed as bifunctional reagents. The reaction system is reliable, efficient and wide in substrate range, which is suitable for the two...

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Detalles Bibliográficos
Autores principales: Li, Jia, Li, Yu-An, Wu, Ge, Zhang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189915/
https://www.ncbi.nlm.nih.gov/pubmed/35707457
http://dx.doi.org/10.3389/fchem.2022.917371
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author Li, Jia
Li, Yu-An
Wu, Ge
Zhang, Xu
author_facet Li, Jia
Li, Yu-An
Wu, Ge
Zhang, Xu
author_sort Li, Jia
collection PubMed
description A simple and practical strategy for intermolecular aminohalogenation of quinone with alkyl amines and NXS was developed, in which haloamines generated in situ were employed as bifunctional reagents. The reaction system is reliable, efficient and wide in substrate range, which is suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals.
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spelling pubmed-91899152022-06-14 Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature Li, Jia Li, Yu-An Wu, Ge Zhang, Xu Front Chem Chemistry A simple and practical strategy for intermolecular aminohalogenation of quinone with alkyl amines and NXS was developed, in which haloamines generated in situ were employed as bifunctional reagents. The reaction system is reliable, efficient and wide in substrate range, which is suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9189915/ /pubmed/35707457 http://dx.doi.org/10.3389/fchem.2022.917371 Text en Copyright © 2022 Li, Li, Wu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Li, Jia
Li, Yu-An
Wu, Ge
Zhang, Xu
Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature
title Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature
title_full Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature
title_fullStr Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature
title_full_unstemmed Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature
title_short Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature
title_sort metal-free aminohalogenation of quinones with alkylamines and nxs at room temperature
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189915/
https://www.ncbi.nlm.nih.gov/pubmed/35707457
http://dx.doi.org/10.3389/fchem.2022.917371
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