Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery

Giardiasis is a diarrheal disease caused by the unicellular parasite Giardia intestinalis, for which metronidazole is the main treatment option. The parasite is dependent on exogenous deoxyribonucleosides for DNA replication and thus is also potentially vulnerable to deoxyribonucleoside analogs. Her...

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Detalles Bibliográficos
Autores principales: Krakovka, Sascha, Ranjbarian, Farahnaz, Luján, Lucas A., Saura, Alicia, Larsen, Nicolai B., Jiménez-González, Alejandro, Reggenti, Anna, Luján, Hugo D., Svärd, Staffan G., Hofer, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190010/
https://www.ncbi.nlm.nih.gov/pubmed/35568200
http://dx.doi.org/10.1016/j.jbc.2022.102028

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