Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m(1)A22-tRNA methyltransferase TrmK

The enzyme m(1)A22-tRNA methyltransferase (TrmK) catalyzes the transfer of a methyl group to the N1 of adenine 22 in bacterial tRNAs. TrmK is essential for Staphylococcus aureus survival during infection but has no homolog in mammals, making it a promising target for antibiotic development. Here, we...

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Detalles Bibliográficos
Autores principales: Sweeney, Pamela, Galliford, Ashleigh, Kumar, Abhishek, Raju, Dinesh, Krishna, Naveen B., Sutherland, Emmajay, Leo, Caitlin J., Fisher, Gemma, Lalitha, Roopa, Muthuraj, Likith, Sigamani, Gladstone, Oehler, Verena, Synowsky, Silvia, Shirran, Sally L., Gloster, Tracey M., Czekster, Clarissa M., Kumar, Pravin, da Silva, Rafael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190014/
https://www.ncbi.nlm.nih.gov/pubmed/35595101
http://dx.doi.org/10.1016/j.jbc.2022.102040

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