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Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation

[Image: see text] Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the parasite Trypanosoma brucei (T.b.). A validated target for the treatment of HAT is the parasitic T.b. cyclic nucleotide phosphodiesterase B1 (TbrPDEB1). Although nanomolar TbrPDEB1 inhibitors have bee...

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Detalles Bibliográficos
Autores principales:	Zara, Lorena, Moraca, Francesca, Van Muijlwijk-Koezen, Jacqueline E., Zarzycka, Barbara, Abel, Robert, de Esch, Iwan J. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190044/ https://www.ncbi.nlm.nih.gov/pubmed/35707144 http://dx.doi.org/10.1021/acsmedchemlett.1c00690

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