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Cortico-cognition coupling in treatment resistant schizophrenia
BACKGROUND: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique and investigate...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190061/ https://www.ncbi.nlm.nih.gov/pubmed/35689976 http://dx.doi.org/10.1016/j.nicl.2022.103064 |
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author | Syeda, Warda T. Wannan, Cassandra M.J. Merritt, Antonia H. Raghava, Jayachandra M. Jayaram, Mahesh Velakoulis, Dennis Kristensen, Tina D. Soldatos, Rigas Filippos Tonissen, Shane Thomas, Naveen Ambrosen, Karen S. Sørensen, Mikkel E. Fagerlund, Birgitte Rostrup, Egill Glenthøj, Birte Y. Skafidas, Efstratios Bousman, Chad A. Johnston, Leigh A. Everall, Ian Ebdrup, Bjørn H. Pantelis, Christos |
author_facet | Syeda, Warda T. Wannan, Cassandra M.J. Merritt, Antonia H. Raghava, Jayachandra M. Jayaram, Mahesh Velakoulis, Dennis Kristensen, Tina D. Soldatos, Rigas Filippos Tonissen, Shane Thomas, Naveen Ambrosen, Karen S. Sørensen, Mikkel E. Fagerlund, Birgitte Rostrup, Egill Glenthøj, Birte Y. Skafidas, Efstratios Bousman, Chad A. Johnston, Leigh A. Everall, Ian Ebdrup, Bjørn H. Pantelis, Christos |
author_sort | Syeda, Warda T. |
collection | PubMed |
description | BACKGROUND: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique and investigated multivariate cortico-cognitive patterns in patients with treatment-resistant schizophrenia (TRS) and matched healthy controls (HC). METHOD: Forty-one TRS patients (age 38.5 ± 9.1, 30 males (M)), and 45 HC (age 40.2 ± 10.6, 29 M) underwent 3T structural MRI. Volumes of 68 brain regions and seven variables from CANTAB covering memory and executive domains were included. Univariate group differences were assessed, followed by the MB-PLS-C analyses to identify group-specific multivariate patterns of cortico-cognitive coupling. Supplementary three-group analyses, which included 23 non-affected first-degree relatives (NAR), were also conducted. RESULTS: Univariate tests demonstrated that TRS patients showed impairments in all seven cognitive tasks and volume reductions in 12 cortical regions following Bonferroni correction. The MB-PLS-C analyses revealed two significant latent variables (LVs) explaining > 90% of the sum-of-squares variance. LV1 explained 78.86% of the sum-of-squares variance, describing a shared, widespread structure-cognitive pattern relevant to both TRS patients and HCs. In contrast, LV2 (13.47% of sum-of-squares variance explained) appeared specific to TRS and comprised a differential cortico-cognitive pattern including frontal and temporal lobes as well as paired associates learning (PAL) and intra-extra dimensional set shifting (IED). Three-group analyses also identified two significant LVs, with NARs more closely resembling healthy controls than TRS patients. CONCLUSIONS: MB-PLS-C analyses identified multivariate brain structural-cognitive patterns in the latent space that may provide a TRS signature. |
format | Online Article Text |
id | pubmed-9190061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-91900612022-06-14 Cortico-cognition coupling in treatment resistant schizophrenia Syeda, Warda T. Wannan, Cassandra M.J. Merritt, Antonia H. Raghava, Jayachandra M. Jayaram, Mahesh Velakoulis, Dennis Kristensen, Tina D. Soldatos, Rigas Filippos Tonissen, Shane Thomas, Naveen Ambrosen, Karen S. Sørensen, Mikkel E. Fagerlund, Birgitte Rostrup, Egill Glenthøj, Birte Y. Skafidas, Efstratios Bousman, Chad A. Johnston, Leigh A. Everall, Ian Ebdrup, Bjørn H. Pantelis, Christos Neuroimage Clin Regular Article BACKGROUND: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique and investigated multivariate cortico-cognitive patterns in patients with treatment-resistant schizophrenia (TRS) and matched healthy controls (HC). METHOD: Forty-one TRS patients (age 38.5 ± 9.1, 30 males (M)), and 45 HC (age 40.2 ± 10.6, 29 M) underwent 3T structural MRI. Volumes of 68 brain regions and seven variables from CANTAB covering memory and executive domains were included. Univariate group differences were assessed, followed by the MB-PLS-C analyses to identify group-specific multivariate patterns of cortico-cognitive coupling. Supplementary three-group analyses, which included 23 non-affected first-degree relatives (NAR), were also conducted. RESULTS: Univariate tests demonstrated that TRS patients showed impairments in all seven cognitive tasks and volume reductions in 12 cortical regions following Bonferroni correction. The MB-PLS-C analyses revealed two significant latent variables (LVs) explaining > 90% of the sum-of-squares variance. LV1 explained 78.86% of the sum-of-squares variance, describing a shared, widespread structure-cognitive pattern relevant to both TRS patients and HCs. In contrast, LV2 (13.47% of sum-of-squares variance explained) appeared specific to TRS and comprised a differential cortico-cognitive pattern including frontal and temporal lobes as well as paired associates learning (PAL) and intra-extra dimensional set shifting (IED). Three-group analyses also identified two significant LVs, with NARs more closely resembling healthy controls than TRS patients. CONCLUSIONS: MB-PLS-C analyses identified multivariate brain structural-cognitive patterns in the latent space that may provide a TRS signature. Elsevier 2022-05-28 /pmc/articles/PMC9190061/ /pubmed/35689976 http://dx.doi.org/10.1016/j.nicl.2022.103064 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Syeda, Warda T. Wannan, Cassandra M.J. Merritt, Antonia H. Raghava, Jayachandra M. Jayaram, Mahesh Velakoulis, Dennis Kristensen, Tina D. Soldatos, Rigas Filippos Tonissen, Shane Thomas, Naveen Ambrosen, Karen S. Sørensen, Mikkel E. Fagerlund, Birgitte Rostrup, Egill Glenthøj, Birte Y. Skafidas, Efstratios Bousman, Chad A. Johnston, Leigh A. Everall, Ian Ebdrup, Bjørn H. Pantelis, Christos Cortico-cognition coupling in treatment resistant schizophrenia |
title | Cortico-cognition coupling in treatment resistant schizophrenia |
title_full | Cortico-cognition coupling in treatment resistant schizophrenia |
title_fullStr | Cortico-cognition coupling in treatment resistant schizophrenia |
title_full_unstemmed | Cortico-cognition coupling in treatment resistant schizophrenia |
title_short | Cortico-cognition coupling in treatment resistant schizophrenia |
title_sort | cortico-cognition coupling in treatment resistant schizophrenia |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190061/ https://www.ncbi.nlm.nih.gov/pubmed/35689976 http://dx.doi.org/10.1016/j.nicl.2022.103064 |
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