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COVID-19 cutaneous manifestations in children and adolescents: a systematic review
OBJECTIVE: The aim of this study was to evaluate the coronavirus disease 2019 (COVID-19) cutaneous manifestations described in pediatric patients and discuss their relevance for early diagnosis. DATA SOURCE: The study consisted of a systematic review of original articles indexed in PubMed and Embase...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade de Pediatria de São Paulo
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190479/ https://www.ncbi.nlm.nih.gov/pubmed/35703724 http://dx.doi.org/10.1590/1984-0462/2022/40/2021134IN |
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author | Pasquini, Ricardo Mazzo, Felipe Antonio Torres Vieira, Fernanda de Almeida Bueno, Gustavo de Souza Previdi, João Vitor Correa da Silva, Lara Rozetti da Silva, Nasthia Kreuz Baziulis Jorizzo, Joseph Lucius Cerci, Felipe Bochnia |
author_facet | Pasquini, Ricardo Mazzo, Felipe Antonio Torres Vieira, Fernanda de Almeida Bueno, Gustavo de Souza Previdi, João Vitor Correa da Silva, Lara Rozetti da Silva, Nasthia Kreuz Baziulis Jorizzo, Joseph Lucius Cerci, Felipe Bochnia |
author_sort | Pasquini, Ricardo |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to evaluate the coronavirus disease 2019 (COVID-19) cutaneous manifestations described in pediatric patients and discuss their relevance for early diagnosis. DATA SOURCE: The study consisted of a systematic review of original articles indexed in PubMed and Embase databases, as well as gray literature articles found through Google Scholar. A search strategy, based on PICO (Patient, Intervention, Comparison, Outcome) Tool, with the terms “child,” “infant,” “childhood,” “adolescents,” “teenagers,” “COVID-19,” “SARS-CoV-2,” and “skin manifestations,” was performed to optimize the findings. The study did not restrict any article regarding language. DATA SYNTHESIS: Out of the 310 articles that initially met the inclusion criteria, 35 were selected for review, totalizing 369 patients. The most common COVID-19 cutaneous manifestations in children and adolescents were Chilblain-like lesions, presented in 67.5% of the cases, followed by erythema multiforme-like (31.7%) and varicella-like lesions (0.8%). The Chilblain-like lesions appeared 7.6 days (95%CI 7.4–7.8) after the viral infection and lasted for 17.5 days (95%CI 16.5–18.5), erythema multiforme-like lesions appeared in 9.5 days (95%CI 9–10) and lasted for 10.3 days (95%CI 9.1–11.5), and varicella-like lesions appeared in 12.3 days (95%CI 4–20.6) and lasted for 7 days. CONCLUSIONS: Knowledge of the different skin manifestations in children and adolescents with COVID-19 is essential for an early diagnosis and, consequently, the possibility of promptly care adoption as well as to interrupt the new coronavirus transmission chains in the current pandemic context. |
format | Online Article Text |
id | pubmed-9190479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade de Pediatria de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-91904792022-06-24 COVID-19 cutaneous manifestations in children and adolescents: a systematic review Pasquini, Ricardo Mazzo, Felipe Antonio Torres Vieira, Fernanda de Almeida Bueno, Gustavo de Souza Previdi, João Vitor Correa da Silva, Lara Rozetti da Silva, Nasthia Kreuz Baziulis Jorizzo, Joseph Lucius Cerci, Felipe Bochnia Rev Paul Pediatr Review Article OBJECTIVE: The aim of this study was to evaluate the coronavirus disease 2019 (COVID-19) cutaneous manifestations described in pediatric patients and discuss their relevance for early diagnosis. DATA SOURCE: The study consisted of a systematic review of original articles indexed in PubMed and Embase databases, as well as gray literature articles found through Google Scholar. A search strategy, based on PICO (Patient, Intervention, Comparison, Outcome) Tool, with the terms “child,” “infant,” “childhood,” “adolescents,” “teenagers,” “COVID-19,” “SARS-CoV-2,” and “skin manifestations,” was performed to optimize the findings. The study did not restrict any article regarding language. DATA SYNTHESIS: Out of the 310 articles that initially met the inclusion criteria, 35 were selected for review, totalizing 369 patients. The most common COVID-19 cutaneous manifestations in children and adolescents were Chilblain-like lesions, presented in 67.5% of the cases, followed by erythema multiforme-like (31.7%) and varicella-like lesions (0.8%). The Chilblain-like lesions appeared 7.6 days (95%CI 7.4–7.8) after the viral infection and lasted for 17.5 days (95%CI 16.5–18.5), erythema multiforme-like lesions appeared in 9.5 days (95%CI 9–10) and lasted for 10.3 days (95%CI 9.1–11.5), and varicella-like lesions appeared in 12.3 days (95%CI 4–20.6) and lasted for 7 days. CONCLUSIONS: Knowledge of the different skin manifestations in children and adolescents with COVID-19 is essential for an early diagnosis and, consequently, the possibility of promptly care adoption as well as to interrupt the new coronavirus transmission chains in the current pandemic context. Sociedade de Pediatria de São Paulo 2022-06-10 /pmc/articles/PMC9190479/ /pubmed/35703724 http://dx.doi.org/10.1590/1984-0462/2022/40/2021134IN Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Review Article Pasquini, Ricardo Mazzo, Felipe Antonio Torres Vieira, Fernanda de Almeida Bueno, Gustavo de Souza Previdi, João Vitor Correa da Silva, Lara Rozetti da Silva, Nasthia Kreuz Baziulis Jorizzo, Joseph Lucius Cerci, Felipe Bochnia COVID-19 cutaneous manifestations in children and adolescents: a systematic review |
title | COVID-19 cutaneous manifestations in children and adolescents: a systematic review |
title_full | COVID-19 cutaneous manifestations in children and adolescents: a systematic review |
title_fullStr | COVID-19 cutaneous manifestations in children and adolescents: a systematic review |
title_full_unstemmed | COVID-19 cutaneous manifestations in children and adolescents: a systematic review |
title_short | COVID-19 cutaneous manifestations in children and adolescents: a systematic review |
title_sort | covid-19 cutaneous manifestations in children and adolescents: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190479/ https://www.ncbi.nlm.nih.gov/pubmed/35703724 http://dx.doi.org/10.1590/1984-0462/2022/40/2021134IN |
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