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SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway

Axin1 is a fundamental scaffolding protein of the destruction complex in the canonical Wnt signaling pathway, which plays a critical role in various biological processes. However, how Axin1 is regulated in the activation of the canonical Wnt signaling pathway remains elusive. Here, we report that Ax...

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Detalles Bibliográficos
Autores principales: Wang, Yuting, Yue, Jicheng, Xiao, Mingzhe, Lu, Xiaomei, Chin, Yuen Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190513/
https://www.ncbi.nlm.nih.gov/pubmed/35707358
http://dx.doi.org/10.3389/fonc.2022.872444