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Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models

Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system and include some of the deadliest cancers. Almost all the conventional and new treatments fail to hinder tumoral growth of the most malignant brain tumors. This is due to multiple factors, such as in...

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Autores principales: Antonica, Francesco, Aiello, Giuseppe, Soldano, Alessia, Abballe, Luana, Miele, Evelina, Tiberi, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190727/
https://www.ncbi.nlm.nih.gov/pubmed/35706426
http://dx.doi.org/10.3389/fnmol.2022.818696
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author Antonica, Francesco
Aiello, Giuseppe
Soldano, Alessia
Abballe, Luana
Miele, Evelina
Tiberi, Luca
author_facet Antonica, Francesco
Aiello, Giuseppe
Soldano, Alessia
Abballe, Luana
Miele, Evelina
Tiberi, Luca
author_sort Antonica, Francesco
collection PubMed
description Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system and include some of the deadliest cancers. Almost all the conventional and new treatments fail to hinder tumoral growth of the most malignant brain tumors. This is due to multiple factors, such as intra-tumor heterogeneity, the microenvironmental properties of the human brain, and the lack of reliable models to test new therapies. Therefore, creating faithful models for each tumor and discovering tailored treatments pose great challenges in the fight against brain cancer. Over the years, different types of models have been generated, and, in this review, we investigated the advantages and disadvantages of the models currently used.
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spelling pubmed-91907272022-06-14 Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models Antonica, Francesco Aiello, Giuseppe Soldano, Alessia Abballe, Luana Miele, Evelina Tiberi, Luca Front Mol Neurosci Neuroscience Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system and include some of the deadliest cancers. Almost all the conventional and new treatments fail to hinder tumoral growth of the most malignant brain tumors. This is due to multiple factors, such as intra-tumor heterogeneity, the microenvironmental properties of the human brain, and the lack of reliable models to test new therapies. Therefore, creating faithful models for each tumor and discovering tailored treatments pose great challenges in the fight against brain cancer. Over the years, different types of models have been generated, and, in this review, we investigated the advantages and disadvantages of the models currently used. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9190727/ /pubmed/35706426 http://dx.doi.org/10.3389/fnmol.2022.818696 Text en Copyright © 2022 Antonica, Aiello, Soldano, Abballe, Miele and Tiberi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Antonica, Francesco
Aiello, Giuseppe
Soldano, Alessia
Abballe, Luana
Miele, Evelina
Tiberi, Luca
Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models
title Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models
title_full Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models
title_fullStr Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models
title_full_unstemmed Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models
title_short Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models
title_sort modeling brain tumors: a perspective overview of in vivo and organoid models
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190727/
https://www.ncbi.nlm.nih.gov/pubmed/35706426
http://dx.doi.org/10.3389/fnmol.2022.818696
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