Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency

Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a p...

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Autores principales: Sanchez Clemente, Nuria, Penner, Justin, Breuer, Judith, Ip, Winnie, Booth, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190774/
https://www.ncbi.nlm.nih.gov/pubmed/35707532
http://dx.doi.org/10.3389/fimmu.2022.881259
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author Sanchez Clemente, Nuria
Penner, Justin
Breuer, Judith
Ip, Winnie
Booth, Claire
author_facet Sanchez Clemente, Nuria
Penner, Justin
Breuer, Judith
Ip, Winnie
Booth, Claire
author_sort Sanchez Clemente, Nuria
collection PubMed
description Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.
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spelling pubmed-91907742022-06-14 Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency Sanchez Clemente, Nuria Penner, Justin Breuer, Judith Ip, Winnie Booth, Claire Front Immunol Immunology Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9190774/ /pubmed/35707532 http://dx.doi.org/10.3389/fimmu.2022.881259 Text en Copyright © 2022 Sanchez Clemente, Penner, Breuer, Ip and Booth https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sanchez Clemente, Nuria
Penner, Justin
Breuer, Judith
Ip, Winnie
Booth, Claire
Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency
title Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency
title_full Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency
title_fullStr Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency
title_full_unstemmed Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency
title_short Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency
title_sort case report: a severe paediatric presentation of covid-19 in apds2 immunodeficiency
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190774/
https://www.ncbi.nlm.nih.gov/pubmed/35707532
http://dx.doi.org/10.3389/fimmu.2022.881259
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