Cargando…
Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population
BACKGROUND: The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischem...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191198/ https://www.ncbi.nlm.nih.gov/pubmed/35706528 http://dx.doi.org/10.2147/JIR.S360775 |
_version_ | 1784725961551380480 |
---|---|
author | Chen, Linfa Chen, Xinglan Wang, Yajun Li, Shengnan Huang, Shaoting Wu, Zhaochun He, Jiawen Chen, Shaofeng Deng, Fu Zhu, Peiyi Zhong, Wangtao Zhao, Bin Ma, Guoda Li, You |
author_facet | Chen, Linfa Chen, Xinglan Wang, Yajun Li, Shengnan Huang, Shaoting Wu, Zhaochun He, Jiawen Chen, Shaofeng Deng, Fu Zhu, Peiyi Zhong, Wangtao Zhao, Bin Ma, Guoda Li, You |
author_sort | Chen, Linfa |
collection | PubMed |
description | BACKGROUND: The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischemic stroke (IS) in the Southern Chinese population. METHODS: Using an enhanced multi-temperature ligase detection reaction genotyping, 310 IS patients and 324 age-matched healthy controls were genotyped to identify five calgranulin gene variants. RESULTS: According to the obtained results, the S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants were linked to a higher risk of IS, while the S100A9 rs3014866 variant was associated with a lower risk of IS. Moreover, the T-T-C-A-T, T-T-C-G-T, or C-C-C-G-C haplotypes have been linked to a greater risk of developing IS, according to haplotype analysis. The occurrence of the variant C allele there in S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants may impart a greater risk of stroke in the LAA subtype, according to further stratification by IS subtypes, while the T allele of the S100A9 rs3014866 variant may be linked to a reduced risk of stroke of all subtypes. Furthermore, patients with the variant C allele of the S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants presented with increased circulating S100A8 and S100A12 levels and larger infarct volumes relative to those with the major TT genotype. CONCLUSION: Our findings suggest that calgranulin gene variants are linked to IS susceptibility, implying that the calgranulin gene may be a potential biomarker for IS prevention and personalized treatment. |
format | Online Article Text |
id | pubmed-9191198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-91911982022-06-14 Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population Chen, Linfa Chen, Xinglan Wang, Yajun Li, Shengnan Huang, Shaoting Wu, Zhaochun He, Jiawen Chen, Shaofeng Deng, Fu Zhu, Peiyi Zhong, Wangtao Zhao, Bin Ma, Guoda Li, You J Inflamm Res Original Research BACKGROUND: The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischemic stroke (IS) in the Southern Chinese population. METHODS: Using an enhanced multi-temperature ligase detection reaction genotyping, 310 IS patients and 324 age-matched healthy controls were genotyped to identify five calgranulin gene variants. RESULTS: According to the obtained results, the S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants were linked to a higher risk of IS, while the S100A9 rs3014866 variant was associated with a lower risk of IS. Moreover, the T-T-C-A-T, T-T-C-G-T, or C-C-C-G-C haplotypes have been linked to a greater risk of developing IS, according to haplotype analysis. The occurrence of the variant C allele there in S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants may impart a greater risk of stroke in the LAA subtype, according to further stratification by IS subtypes, while the T allele of the S100A9 rs3014866 variant may be linked to a reduced risk of stroke of all subtypes. Furthermore, patients with the variant C allele of the S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants presented with increased circulating S100A8 and S100A12 levels and larger infarct volumes relative to those with the major TT genotype. CONCLUSION: Our findings suggest that calgranulin gene variants are linked to IS susceptibility, implying that the calgranulin gene may be a potential biomarker for IS prevention and personalized treatment. Dove 2022-06-09 /pmc/articles/PMC9191198/ /pubmed/35706528 http://dx.doi.org/10.2147/JIR.S360775 Text en © 2022 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Chen, Linfa Chen, Xinglan Wang, Yajun Li, Shengnan Huang, Shaoting Wu, Zhaochun He, Jiawen Chen, Shaofeng Deng, Fu Zhu, Peiyi Zhong, Wangtao Zhao, Bin Ma, Guoda Li, You Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population |
title | Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population |
title_full | Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population |
title_fullStr | Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population |
title_full_unstemmed | Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population |
title_short | Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population |
title_sort | polymorphisms of calgranulin genes and ischemic stroke in a chinese population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191198/ https://www.ncbi.nlm.nih.gov/pubmed/35706528 http://dx.doi.org/10.2147/JIR.S360775 |
work_keys_str_mv | AT chenlinfa polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT chenxinglan polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT wangyajun polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT lishengnan polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT huangshaoting polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT wuzhaochun polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT hejiawen polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT chenshaofeng polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT dengfu polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT zhupeiyi polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT zhongwangtao polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT zhaobin polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT maguoda polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation AT liyou polymorphismsofcalgranulingenesandischemicstrokeinachinesepopulation |