Cargando…
Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
INTRODUCTION: Angiosarcoma secondary to post-irradiation and lymphedema is rare, but it is aggressive with a poor prognosis. It is essential to understand these patients’ clinical features and distinguish them from benign diseases or other malignant tumors. PATIENT CONCERNS: Three patients who had r...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191316/ https://www.ncbi.nlm.nih.gov/pubmed/35049205 http://dx.doi.org/10.1097/MD.0000000000027985 |
_version_ | 1784725985945452544 |
---|---|
author | Yoon, Jin A. Shin, Myung Jun Shin, Yong Beom Lee, Byeong Ju Choi, Kyung Un Kim, Joo Hyoung |
author_facet | Yoon, Jin A. Shin, Myung Jun Shin, Yong Beom Lee, Byeong Ju Choi, Kyung Un Kim, Joo Hyoung |
author_sort | Yoon, Jin A. |
collection | PubMed |
description | INTRODUCTION: Angiosarcoma secondary to post-irradiation and lymphedema is rare, but it is aggressive with a poor prognosis. It is essential to understand these patients’ clinical features and distinguish them from benign diseases or other malignant tumors. PATIENT CONCERNS: Three patients who had radiotherapy for cancer treatment and chronic lymphedema admitted to the hospital with specific skin lesions at upper or lower extremities. DIAGNOSIS: Excisional biopsies revealed prominent, highly atypical cells with a vasoformative area, composed of atypical, large epithelioid cells with vesicular nuclei, prominent nucleoli, and mitoses. Immunohistochemistry revealed diffuse expression of endothelial cell markers suggestive of angiosarcoma. INTERVENTIONS: One patient had shoulder disarticulation with wide excision with adjuvant radiotherapy and chemotherapy and other 2 discontinued the treatment. OUTCOMES: After the treatment, one patient was transferred to rehabilitation department for shoulder disarticulation prosthesis fitting without recurrence sign for 1 year. Two patient refused further treatment and was lost to follow-up. CONCLUSION: In cases of patients with irratiation and chronic lymphedema, clinical findings suggestive of angiosarcoma, biopsy and imaging studies should be performed as soon as possible. |
format | Online Article Text |
id | pubmed-9191316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-91913162022-06-13 Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports Yoon, Jin A. Shin, Myung Jun Shin, Yong Beom Lee, Byeong Ju Choi, Kyung Un Kim, Joo Hyoung Medicine (Baltimore) 4000 INTRODUCTION: Angiosarcoma secondary to post-irradiation and lymphedema is rare, but it is aggressive with a poor prognosis. It is essential to understand these patients’ clinical features and distinguish them from benign diseases or other malignant tumors. PATIENT CONCERNS: Three patients who had radiotherapy for cancer treatment and chronic lymphedema admitted to the hospital with specific skin lesions at upper or lower extremities. DIAGNOSIS: Excisional biopsies revealed prominent, highly atypical cells with a vasoformative area, composed of atypical, large epithelioid cells with vesicular nuclei, prominent nucleoli, and mitoses. Immunohistochemistry revealed diffuse expression of endothelial cell markers suggestive of angiosarcoma. INTERVENTIONS: One patient had shoulder disarticulation with wide excision with adjuvant radiotherapy and chemotherapy and other 2 discontinued the treatment. OUTCOMES: After the treatment, one patient was transferred to rehabilitation department for shoulder disarticulation prosthesis fitting without recurrence sign for 1 year. Two patient refused further treatment and was lost to follow-up. CONCLUSION: In cases of patients with irratiation and chronic lymphedema, clinical findings suggestive of angiosarcoma, biopsy and imaging studies should be performed as soon as possible. Lippincott Williams & Wilkins 2021-12-03 /pmc/articles/PMC9191316/ /pubmed/35049205 http://dx.doi.org/10.1097/MD.0000000000027985 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 4000 Yoon, Jin A. Shin, Myung Jun Shin, Yong Beom Lee, Byeong Ju Choi, Kyung Un Kim, Joo Hyoung Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports |
title | Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports |
title_full | Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports |
title_fullStr | Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports |
title_full_unstemmed | Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports |
title_short | Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports |
title_sort | angiosarcoma secondary to postirradiation and chronic lymphedema: case reports |
topic | 4000 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191316/ https://www.ncbi.nlm.nih.gov/pubmed/35049205 http://dx.doi.org/10.1097/MD.0000000000027985 |
work_keys_str_mv | AT yoonjina angiosarcomasecondarytopostirradiationandchroniclymphedemacasereports AT shinmyungjun angiosarcomasecondarytopostirradiationandchroniclymphedemacasereports AT shinyongbeom angiosarcomasecondarytopostirradiationandchroniclymphedemacasereports AT leebyeongju angiosarcomasecondarytopostirradiationandchroniclymphedemacasereports AT choikyungun angiosarcomasecondarytopostirradiationandchroniclymphedemacasereports AT kimjoohyoung angiosarcomasecondarytopostirradiationandchroniclymphedemacasereports |