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Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports

INTRODUCTION: Angiosarcoma secondary to post-irradiation and lymphedema is rare, but it is aggressive with a poor prognosis. It is essential to understand these patients’ clinical features and distinguish them from benign diseases or other malignant tumors. PATIENT CONCERNS: Three patients who had r...

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Autores principales: Yoon, Jin A., Shin, Myung Jun, Shin, Yong Beom, Lee, Byeong Ju, Choi, Kyung Un, Kim, Joo Hyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191316/
https://www.ncbi.nlm.nih.gov/pubmed/35049205
http://dx.doi.org/10.1097/MD.0000000000027985
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author Yoon, Jin A.
Shin, Myung Jun
Shin, Yong Beom
Lee, Byeong Ju
Choi, Kyung Un
Kim, Joo Hyoung
author_facet Yoon, Jin A.
Shin, Myung Jun
Shin, Yong Beom
Lee, Byeong Ju
Choi, Kyung Un
Kim, Joo Hyoung
author_sort Yoon, Jin A.
collection PubMed
description INTRODUCTION: Angiosarcoma secondary to post-irradiation and lymphedema is rare, but it is aggressive with a poor prognosis. It is essential to understand these patients’ clinical features and distinguish them from benign diseases or other malignant tumors. PATIENT CONCERNS: Three patients who had radiotherapy for cancer treatment and chronic lymphedema admitted to the hospital with specific skin lesions at upper or lower extremities. DIAGNOSIS: Excisional biopsies revealed prominent, highly atypical cells with a vasoformative area, composed of atypical, large epithelioid cells with vesicular nuclei, prominent nucleoli, and mitoses. Immunohistochemistry revealed diffuse expression of endothelial cell markers suggestive of angiosarcoma. INTERVENTIONS: One patient had shoulder disarticulation with wide excision with adjuvant radiotherapy and chemotherapy and other 2 discontinued the treatment. OUTCOMES: After the treatment, one patient was transferred to rehabilitation department for shoulder disarticulation prosthesis fitting without recurrence sign for 1 year. Two patient refused further treatment and was lost to follow-up. CONCLUSION: In cases of patients with irratiation and chronic lymphedema, clinical findings suggestive of angiosarcoma, biopsy and imaging studies should be performed as soon as possible.
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spelling pubmed-91913162022-06-13 Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports Yoon, Jin A. Shin, Myung Jun Shin, Yong Beom Lee, Byeong Ju Choi, Kyung Un Kim, Joo Hyoung Medicine (Baltimore) 4000 INTRODUCTION: Angiosarcoma secondary to post-irradiation and lymphedema is rare, but it is aggressive with a poor prognosis. It is essential to understand these patients’ clinical features and distinguish them from benign diseases or other malignant tumors. PATIENT CONCERNS: Three patients who had radiotherapy for cancer treatment and chronic lymphedema admitted to the hospital with specific skin lesions at upper or lower extremities. DIAGNOSIS: Excisional biopsies revealed prominent, highly atypical cells with a vasoformative area, composed of atypical, large epithelioid cells with vesicular nuclei, prominent nucleoli, and mitoses. Immunohistochemistry revealed diffuse expression of endothelial cell markers suggestive of angiosarcoma. INTERVENTIONS: One patient had shoulder disarticulation with wide excision with adjuvant radiotherapy and chemotherapy and other 2 discontinued the treatment. OUTCOMES: After the treatment, one patient was transferred to rehabilitation department for shoulder disarticulation prosthesis fitting without recurrence sign for 1 year. Two patient refused further treatment and was lost to follow-up. CONCLUSION: In cases of patients with irratiation and chronic lymphedema, clinical findings suggestive of angiosarcoma, biopsy and imaging studies should be performed as soon as possible. Lippincott Williams & Wilkins 2021-12-03 /pmc/articles/PMC9191316/ /pubmed/35049205 http://dx.doi.org/10.1097/MD.0000000000027985 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 4000
Yoon, Jin A.
Shin, Myung Jun
Shin, Yong Beom
Lee, Byeong Ju
Choi, Kyung Un
Kim, Joo Hyoung
Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
title Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
title_full Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
title_fullStr Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
title_full_unstemmed Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
title_short Angiosarcoma secondary to postirradiation and chronic lymphedema: Case reports
title_sort angiosarcoma secondary to postirradiation and chronic lymphedema: case reports
topic 4000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191316/
https://www.ncbi.nlm.nih.gov/pubmed/35049205
http://dx.doi.org/10.1097/MD.0000000000027985
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