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Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial

BACKGROUND: Chronic renal failure (CRF) is the final outcome of the development of multiple kidney diseases, and there is no effective method at home and abroad. Traditional Chinese medicine is found to play a major role in the treatment of the non-replacement stage of CRF. Shenkang injection can no...

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Autores principales: Mei, JuXiang, Yang, LingLing, Wang, Deqin, Wang, HaiXia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191390/
https://www.ncbi.nlm.nih.gov/pubmed/35049168
http://dx.doi.org/10.1097/MD.0000000000027748
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author Mei, JuXiang
Yang, LingLing
Wang, Deqin
Wang, HaiXia
author_facet Mei, JuXiang
Yang, LingLing
Wang, Deqin
Wang, HaiXia
author_sort Mei, JuXiang
collection PubMed
description BACKGROUND: Chronic renal failure (CRF) is the final outcome of the development of multiple kidney diseases, and there is no effective method at home and abroad. Traditional Chinese medicine is found to play a major role in the treatment of the non-replacement stage of CRF. Shenkang injection can not only nourish the kidney, but also promote blood circulation and remove blood stasis, which is suitable for the treatment of CRF. This study aims to explore the efficacy and safety of Shenkang injection for CRF and provide evidence for clinical practice. METHODS: This was a prospective randomized controlled trial. One hundred four patients with CRF were randomly divided into treatment groups and control groups according to 1:1, with 52 patients in each group. The control group received basic treatment of western medicine and the treatment group was given Shenkang injection intravenously on the basis of control group. Both groups were given standard treatment for 4 weeks with concurrent follow-up for 1 month. The outcome indicators included: total efficiency, symptom scores, creatinine clearance rate, serum creatinine, blood urea nitrogen, CystatinC, liver function, blood routine, urine routine, incidence of adverse reactions, etc. Data analysis was performed using SPSS 25.0 software. DISCUSSION: This study will evaluate the efficacy and safety of Shenkang injection for CRF, and the results of this trial will provide clinical evidence for the treatment of CRF. TRIAL REGISTRATION: OSF Registration number: DOI 10.17605/OSF.IO/K9C5T.
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spelling pubmed-91913902022-06-14 Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial Mei, JuXiang Yang, LingLing Wang, Deqin Wang, HaiXia Medicine (Baltimore) 5200 BACKGROUND: Chronic renal failure (CRF) is the final outcome of the development of multiple kidney diseases, and there is no effective method at home and abroad. Traditional Chinese medicine is found to play a major role in the treatment of the non-replacement stage of CRF. Shenkang injection can not only nourish the kidney, but also promote blood circulation and remove blood stasis, which is suitable for the treatment of CRF. This study aims to explore the efficacy and safety of Shenkang injection for CRF and provide evidence for clinical practice. METHODS: This was a prospective randomized controlled trial. One hundred four patients with CRF were randomly divided into treatment groups and control groups according to 1:1, with 52 patients in each group. The control group received basic treatment of western medicine and the treatment group was given Shenkang injection intravenously on the basis of control group. Both groups were given standard treatment for 4 weeks with concurrent follow-up for 1 month. The outcome indicators included: total efficiency, symptom scores, creatinine clearance rate, serum creatinine, blood urea nitrogen, CystatinC, liver function, blood routine, urine routine, incidence of adverse reactions, etc. Data analysis was performed using SPSS 25.0 software. DISCUSSION: This study will evaluate the efficacy and safety of Shenkang injection for CRF, and the results of this trial will provide clinical evidence for the treatment of CRF. TRIAL REGISTRATION: OSF Registration number: DOI 10.17605/OSF.IO/K9C5T. Lippincott Williams & Wilkins 2021-12-03 /pmc/articles/PMC9191390/ /pubmed/35049168 http://dx.doi.org/10.1097/MD.0000000000027748 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5200
Mei, JuXiang
Yang, LingLing
Wang, Deqin
Wang, HaiXia
Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial
title Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial
title_full Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial
title_fullStr Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial
title_full_unstemmed Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial
title_short Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial
title_sort efficacy and safety of shenkang injection in the treatment of chronic renal failure: a protocol of a randomized controlled trial
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191390/
https://www.ncbi.nlm.nih.gov/pubmed/35049168
http://dx.doi.org/10.1097/MD.0000000000027748
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