Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters

With the persistence of the SARS-CoV-2 pandemic and the emergence of novel variants, the development of novel vaccine formulations with enhanced immunogenicity profiles could help reduce disease burden in the future. Intranasally delivered vaccines offer a new modality to prevent SARS-CoV-2 infectio...

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Detalles Bibliográficos
Autores principales: Stark, Felicity C., Akache, Bassel, Deschatelets, Lise, Tran, Anh, Stuible, Matthew, Durocher, Yves, McCluskie, Michael J., Agbayani, Gerard, Dudani, Renu, Harrison, Blair A., Renner, Tyler M., Makinen, Shawn R., Bavananthasivam, Jegarubee, Duque, Diana, Gagne, Martin, Zimmermann, Joseph, Zarley, C. David, Cochrane, Terrence R., Handfield, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191540/
https://www.ncbi.nlm.nih.gov/pubmed/35697917
http://dx.doi.org/10.1038/s41598-022-13819-5

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