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Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes

Structural maintenance of chromosomes (SMC) complexes are essential for chromatin organization and functions throughout the cell cycle. The cohesin and condensin SMCs fold and tether DNA, while Smc5/6 directly promotes DNA replication and repair. The functions of SMCs rely on their abilities to enga...

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Detalles Bibliográficos
Autores principales:	Yu, You, Li, Shibai, Ser, Zheng, Kuang, Huihui, Than, Thane, Guan, Danying, Zhao, Xiaolan, Patel, Dinshaw J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191643/ https://www.ncbi.nlm.nih.gov/pubmed/35648833 http://dx.doi.org/10.1073/pnas.2202799119

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