Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2

The utilization of avidity to drive and tune functional responses is fundamental to antibody biology and often underlies the mechanisms of action of monoclonal antibody drugs. There is increasing evidence that antibodies leverage homotypic interactions to enhance avidity, often through weak transien...

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Detalles Bibliográficos
Autores principales: Leonard, Brandon, Sankar, Kannan, Romei, Matthew G., Tse, Margaret J., Do, Nina, Yang, Yanli, Matochko, Wadim L., Bevers, Jack, Bollineni, Sundeep, Mukhyala, Kiran, Hoi, Kam Hon, Lazar, Greg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191654/
https://www.ncbi.nlm.nih.gov/pubmed/35653561
http://dx.doi.org/10.1073/pnas.2201562119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191654/
https://www.ncbi.nlm.nih.gov/pubmed/35653561
http://dx.doi.org/10.1073/pnas.2201562119

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