Cargando…
Why does viral RNA sometimes persist after recovery from acute infections?
DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after cl...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191737/ https://www.ncbi.nlm.nih.gov/pubmed/35648781 http://dx.doi.org/10.1371/journal.pbio.3001687 |
_version_ | 1784726082390327296 |
---|---|
author | Griffin, Diane E. |
author_facet | Griffin, Diane E. |
author_sort | Griffin, Diane E. |
collection | PubMed |
description | DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms, such as may be the case following infection with Ebola or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does viral RNA sometimes persist after recovery from an acute infection? Where does the RNA come from? And what are the consequences? |
format | Online Article Text |
id | pubmed-9191737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91917372022-06-14 Why does viral RNA sometimes persist after recovery from acute infections? Griffin, Diane E. PLoS Biol Unsolved Mystery DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms, such as may be the case following infection with Ebola or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does viral RNA sometimes persist after recovery from an acute infection? Where does the RNA come from? And what are the consequences? Public Library of Science 2022-06-01 /pmc/articles/PMC9191737/ /pubmed/35648781 http://dx.doi.org/10.1371/journal.pbio.3001687 Text en © 2022 Diane E. Griffin https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Unsolved Mystery Griffin, Diane E. Why does viral RNA sometimes persist after recovery from acute infections? |
title | Why does viral RNA sometimes persist after recovery from acute infections? |
title_full | Why does viral RNA sometimes persist after recovery from acute infections? |
title_fullStr | Why does viral RNA sometimes persist after recovery from acute infections? |
title_full_unstemmed | Why does viral RNA sometimes persist after recovery from acute infections? |
title_short | Why does viral RNA sometimes persist after recovery from acute infections? |
title_sort | why does viral rna sometimes persist after recovery from acute infections? |
topic | Unsolved Mystery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191737/ https://www.ncbi.nlm.nih.gov/pubmed/35648781 http://dx.doi.org/10.1371/journal.pbio.3001687 |
work_keys_str_mv | AT griffindianee whydoesviralrnasometimespersistafterrecoveryfromacuteinfections |