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Why does viral RNA sometimes persist after recovery from acute infections?

DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after cl...

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Detalles Bibliográficos
Autor principal: Griffin, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191737/
https://www.ncbi.nlm.nih.gov/pubmed/35648781
http://dx.doi.org/10.1371/journal.pbio.3001687
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author Griffin, Diane E.
author_facet Griffin, Diane E.
author_sort Griffin, Diane E.
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description DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms, such as may be the case following infection with Ebola or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does viral RNA sometimes persist after recovery from an acute infection? Where does the RNA come from? And what are the consequences?
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spelling pubmed-91917372022-06-14 Why does viral RNA sometimes persist after recovery from acute infections? Griffin, Diane E. PLoS Biol Unsolved Mystery DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms, such as may be the case following infection with Ebola or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does viral RNA sometimes persist after recovery from an acute infection? Where does the RNA come from? And what are the consequences? Public Library of Science 2022-06-01 /pmc/articles/PMC9191737/ /pubmed/35648781 http://dx.doi.org/10.1371/journal.pbio.3001687 Text en © 2022 Diane E. Griffin https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Unsolved Mystery
Griffin, Diane E.
Why does viral RNA sometimes persist after recovery from acute infections?
title Why does viral RNA sometimes persist after recovery from acute infections?
title_full Why does viral RNA sometimes persist after recovery from acute infections?
title_fullStr Why does viral RNA sometimes persist after recovery from acute infections?
title_full_unstemmed Why does viral RNA sometimes persist after recovery from acute infections?
title_short Why does viral RNA sometimes persist after recovery from acute infections?
title_sort why does viral rna sometimes persist after recovery from acute infections?
topic Unsolved Mystery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191737/
https://www.ncbi.nlm.nih.gov/pubmed/35648781
http://dx.doi.org/10.1371/journal.pbio.3001687
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