Nrf2 deficiency causes hepatocyte dedifferentiation and reduced albumin production in an experimental extrahepatic cholestasis model

The transcription factor Nrf2 modulates the initiation and progression of a number of diseases including liver disorders. We evaluated whether Nrf2 mediates hepatic adaptive responses to cholestasis. Wild-type and Nrf2-null mice were subjected to bile duct ligation (BDL) or a sham operation. As chol...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Guo-Ying, Garcia, Veronica, Lee, Joonyong, Yanum, Jennifer, Lin, Jingmei, Jiang, Huaizhou, Dai, Guoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191739/
https://www.ncbi.nlm.nih.gov/pubmed/35696363
http://dx.doi.org/10.1371/journal.pone.0269383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191739/
https://www.ncbi.nlm.nih.gov/pubmed/35696363
http://dx.doi.org/10.1371/journal.pone.0269383

Ejemplares similares