Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to gen...

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Detalles Bibliográficos
Autores principales: Pillon, Nicolas J., Loos, Ruth J.F., Marshall, Sally M., Zierath, Juleen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191863/
https://www.ncbi.nlm.nih.gov/pubmed/33675692
http://dx.doi.org/10.1016/j.cell.2021.02.012
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author Pillon, Nicolas J.
Loos, Ruth J.F.
Marshall, Sally M.
Zierath, Juleen R.
author_facet Pillon, Nicolas J.
Loos, Ruth J.F.
Marshall, Sally M.
Zierath, Juleen R.
author_sort Pillon, Nicolas J.
collection PubMed
description The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.
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spelling pubmed-91918632022-06-14 Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care Pillon, Nicolas J. Loos, Ruth J.F. Marshall, Sally M. Zierath, Juleen R. Cell Review The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases. The Author(s). Published by Elsevier Inc. 2021-03-18 2021-03-05 /pmc/articles/PMC9191863/ /pubmed/33675692 http://dx.doi.org/10.1016/j.cell.2021.02.012 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Pillon, Nicolas J.
Loos, Ruth J.F.
Marshall, Sally M.
Zierath, Juleen R.
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
title Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
title_full Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
title_fullStr Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
title_full_unstemmed Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
title_short Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
title_sort metabolic consequences of obesity and type 2 diabetes: balancing genes and environment for personalized care
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191863/
https://www.ncbi.nlm.nih.gov/pubmed/33675692
http://dx.doi.org/10.1016/j.cell.2021.02.012
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