Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19

Unique challenges arise when conducting trials to evaluate therapies already in common clinical use, including difficulty enrolling patients owing to widespread open-label use of trial therapies and the need for large sample sizes to detect small but clinically meaningful treatment effects. Despite...

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Detalles Bibliográficos
Autores principales: Casey, Jonathan D, Beskow, Laura M, Brown, Jeremy, Brown, Samuel M, Gayat, Étienne, Ng Gong, Michelle, Harhay, Michael O, Jaber, Samir, Jentzer, Jacob C, Laterre, Pierre-François, Marshall, John C, Matthay, Michael A, Rice, Todd W, Rosenberg, Yves, Turnbull, Alison E, Ware, Lorraine B, Self, Wesley H, Mebazaa, Alexandre, Collins, Sean P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191864/
https://www.ncbi.nlm.nih.gov/pubmed/35709825
http://dx.doi.org/10.1016/S2213-2600(22)00044-3

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