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Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant women might affect both maternal and neonatal outcomes. Based on the inconsistency between the results of the previous studies and the lack of data about the possible vertical transmission of SARS-CoV-2, we desig...

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Autores principales: Saleh Gargari, Soraya, Rahmati, Nayyereh, Fateh, Reyhaneh, Khandani, Ayda, Nikfar, Somayeh, Ghafouri-Fard, Soudeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191880/
https://www.ncbi.nlm.nih.gov/pubmed/35697859
http://dx.doi.org/10.1038/s41598-022-14112-1
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author Saleh Gargari, Soraya
Rahmati, Nayyereh
Fateh, Reyhaneh
Khandani, Ayda
Nikfar, Somayeh
Ghafouri-Fard, Soudeh
author_facet Saleh Gargari, Soraya
Rahmati, Nayyereh
Fateh, Reyhaneh
Khandani, Ayda
Nikfar, Somayeh
Ghafouri-Fard, Soudeh
author_sort Saleh Gargari, Soraya
collection PubMed
description Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant women might affect both maternal and neonatal outcomes. Based on the inconsistency between the results of the previous studies and the lack of data about the possible vertical transmission of SARS-CoV-2, we designed the present study to investigate the maternal and perinatal outcomes in 182 Iranian pregnant women infected with COVID-19. Among 40 PCR tests conducted on neonatal throat samples, 11 tests were positive. Among the assessed women, 22 women needed ICU admission and 30 premature labors occurred. There were significant associations between ICU admission and many parameters such as the presence of dyspnea (P < 0.001), COVID-19-related CT scan findings (P = 0.003), need for a ventilator (P < 0.001), and low O(2) saturation (P < 0.001), all of which indicate the critical situation of patients. Notably, the cause of delivery was significantly different in both groups, with labor pain and fetal distress being the most frequent causes of delivery in non-ICU and ICU-admitted patients, respectively. Moreover, delivery route (P = 0.003), frequencies of IUGR (P = 0.042), neonatal death (P = 0.008) and asphyxia (P = 0.016), Apgar score (P = 0.003), and gestational age at delivery (P = 0.009) have been associated with ICU admission. The present investigation exhibits association between the critical situation of pregnant women affected with COVID-19 and some adverse neonatal outcomes.
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spelling pubmed-91918802022-06-15 Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19 Saleh Gargari, Soraya Rahmati, Nayyereh Fateh, Reyhaneh Khandani, Ayda Nikfar, Somayeh Ghafouri-Fard, Soudeh Sci Rep Article Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant women might affect both maternal and neonatal outcomes. Based on the inconsistency between the results of the previous studies and the lack of data about the possible vertical transmission of SARS-CoV-2, we designed the present study to investigate the maternal and perinatal outcomes in 182 Iranian pregnant women infected with COVID-19. Among 40 PCR tests conducted on neonatal throat samples, 11 tests were positive. Among the assessed women, 22 women needed ICU admission and 30 premature labors occurred. There were significant associations between ICU admission and many parameters such as the presence of dyspnea (P < 0.001), COVID-19-related CT scan findings (P = 0.003), need for a ventilator (P < 0.001), and low O(2) saturation (P < 0.001), all of which indicate the critical situation of patients. Notably, the cause of delivery was significantly different in both groups, with labor pain and fetal distress being the most frequent causes of delivery in non-ICU and ICU-admitted patients, respectively. Moreover, delivery route (P = 0.003), frequencies of IUGR (P = 0.042), neonatal death (P = 0.008) and asphyxia (P = 0.016), Apgar score (P = 0.003), and gestational age at delivery (P = 0.009) have been associated with ICU admission. The present investigation exhibits association between the critical situation of pregnant women affected with COVID-19 and some adverse neonatal outcomes. Nature Publishing Group UK 2022-06-13 /pmc/articles/PMC9191880/ /pubmed/35697859 http://dx.doi.org/10.1038/s41598-022-14112-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Saleh Gargari, Soraya
Rahmati, Nayyereh
Fateh, Reyhaneh
Khandani, Ayda
Nikfar, Somayeh
Ghafouri-Fard, Soudeh
Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19
title Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19
title_full Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19
title_fullStr Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19
title_full_unstemmed Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19
title_short Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19
title_sort investigation of maternal and perinatal outcome in a population of iranian pregnant women infected with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191880/
https://www.ncbi.nlm.nih.gov/pubmed/35697859
http://dx.doi.org/10.1038/s41598-022-14112-1
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