Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family

Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a...

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Autores principales: Tukek, Tufan, Pehlivan, Sacide, Oyaci, Yasemin, Isoglu-Alkac, Ummuhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192174/
https://www.ncbi.nlm.nih.gov/pubmed/35707789
http://dx.doi.org/10.1055/s-0042-1743258
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author Tukek, Tufan
Pehlivan, Sacide
Oyaci, Yasemin
Isoglu-Alkac, Ummuhan
author_facet Tukek, Tufan
Pehlivan, Sacide
Oyaci, Yasemin
Isoglu-Alkac, Ummuhan
author_sort Tukek, Tufan
collection PubMed
description Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19.
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spelling pubmed-91921742022-06-14 Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family Tukek, Tufan Pehlivan, Sacide Oyaci, Yasemin Isoglu-Alkac, Ummuhan Glob Med Genet Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19. Georg Thieme Verlag KG 2022-06-13 /pmc/articles/PMC9192174/ /pubmed/35707789 http://dx.doi.org/10.1055/s-0042-1743258 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Tukek, Tufan
Pehlivan, Sacide
Oyaci, Yasemin
Isoglu-Alkac, Ummuhan
Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
title Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
title_full Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
title_fullStr Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
title_full_unstemmed Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
title_short Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
title_sort mannose-binding lectin 2 gene polymorphism during pandemic: covid-19 family
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192174/
https://www.ncbi.nlm.nih.gov/pubmed/35707789
http://dx.doi.org/10.1055/s-0042-1743258
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