Cargando…

Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter

The upregulation telomerase activity is observed in over 85-90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G-quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Wei, Lin, Zihan, Zhao, Shengchao, Wang, Guanzhen, Shen, Ziyi, Liu, Wei, Cai, Yi, Wang, Kaibo, Wan, Chunpeng Craig, Yan, Tingdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192192/ https://www.ncbi.nlm.nih.gov/pubmed/35707279 http://dx.doi.org/10.1155/2022/2905663

Ejemplares similares

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
por: Ramlee, Muhammad Khairul, et al.
Publicado: (2016)

Human Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo
por: Wyatt, Haley D. M., et al.
Publicado: (2009)

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
por: Leão, Ricardo, et al.
Publicado: (2018)

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia
por: Yik, Mot Yee, et al.
Publicado: (2021)

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours
por: Lantuejoul, S, et al.
Publicado: (2004)

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
por: Yang, Ruozhu, et al.
Publicado: (2023)

Naïve T-cells in Myelodysplastic Syndrome Display Intrinsic Human Telomerase Reverse Transcriptase (hTERT) Deficiency
por: Yang, Lili, et al.
Publicado: (2012)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)
por: Kuhlmann, Anne-Sophie, et al.
Publicado: (2007)

Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells
por: Jaiswal, Rishi Kumar, et al.
Publicado: (2017)

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
por: Xu, D, et al.
Publicado: (1999)

Copy-number-gain of telomerase reverse transcriptase (hTERT) is associated with an unfavorable prognosis in esophageal adenocarcinoma
por: Lyu, Su Ir, et al.
Publicado: (2023)

Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
por: Khosravi- Maharlooei, Mohsen, et al.
Publicado: (2015)

Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression
por: Tang, Bo, et al.
Publicado: (2015)

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene
por: Zhu, Qingjun, et al.
Publicado: (2008)

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
por: Ma, Chenjing, et al.
Publicado: (2023)

In silico Analysis of Human Telomerase Reverse Transcriptase (hTERT) Gene: Identification of a Distant Homolog of Melanoma Antigen Family Gene (MAGE)
por: Amin, Ruhul, et al.
Publicado: (2009)

Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism
por: La, Sun-Hyuk, et al.
Publicado: (2016)

Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human Umbilical Vein Endothelial Cells
por: Behjati, Mohaddeseh, et al.
Publicado: (2017)

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
por: Khattar, Ekta, et al.
Publicado: (2017)

mRNA quantification and clinical evaluation of telomerase reverse transcriptase subunit (hTERT) in intracranial tumours of patients in the island of Crete
por: Yannopoulos, A, et al.
Publicado: (2005)

Expression Pattern of Telomerase Reverse Transcriptase (hTERT) Variants and Bcl-2 in Peripheral Lymphocytes of Systemic Lupus Erythematosus Patients
por: Attar, Armin, et al.
Publicado: (2020)

The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
por: Li, Jian-Jun, et al.
Publicado: (2017)

Interferon-Inducible IFI16, a Negative Regulator of Cell Growth, Down-Regulates Expression of Human Telomerase Reverse Transcriptase (hTERT) Gene
por: Song, Lynda Li, et al.
Publicado: (2010)

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population
por: Zhang, Jian, et al.
Publicado: (2017)

Inhibition of Human Telomerase Reverse Transcritpase (hTERT) and Telomerase Activity by Curcumin in Human Mammary Epithelial and Breast Carcinoma Cell Lines
por: Ramachandran, Chappail, et al.
Publicado: (2001)

An Improved Model for the hTERT Promoter Quadruplex
por: Chaires, Jonathan B., et al.
Publicado: (2014)

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
por: Yuan, Xiaotian, et al.
Publicado: (2019)

Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines
por: McKelvey, Brittany A., et al.
Publicado: (2020)

Cell membrane breakage and triggering T cell infiltration are involved in human telomerase reverse transcriptase (hTERT) promoter-driven novel peptide KK-64 for liver cancer gene therapy
por: Lu, Yuanhua, et al.
Publicado: (2021)

Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion
por: Saha, Dhurjhoti, et al.
Publicado: (2017)

The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
por: Slusher, Aaron L., et al.
Publicado: (2020)

The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer
por: Wan, Song, et al.
Publicado: (2021)

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats
por: Huda, Armela, et al.
Publicado: (2023)

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review
por: McKelvey, Brittany A., et al.
Publicado: (2020)

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
por: Sæbøe-Larssen, Stein, et al.
Publicado: (2006)

Clinical application of the anti‐human telomerase reverse transcriptase (hTERT) antibody (SCD‐A7) immunocytochemistry in liquid‐based urine cytology: A prospective, single institute study
por: Moon, Ji Hye, et al.
Publicado: (2023)

Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutations
por: Tornesello, Maria Lina, et al.
Publicado: (2023)

Human Specific Regulation of the Telomerase Reverse Transcriptase Gene
por: Zhang, Fan, et al.
Publicado: (2016)

Telomere length and hTERT in mania and subsequent remission
por: Çinar, Rugül Köse
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_q38082m9l5fn4bnmj6ei13ikh2