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Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects

OBJECTIVES: The side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and blurring) are important to patients compared t...

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Autores principales: Ozdemir, Semra, Yeo, Sharon Wan Jie, Lee, Jia Jia, Bhaskar, Adithya, Finkelstein, Eric, Tong, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192251/
https://www.ncbi.nlm.nih.gov/pubmed/35697974
http://dx.doi.org/10.1007/s40271-022-00586-8
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author Ozdemir, Semra
Yeo, Sharon Wan Jie
Lee, Jia Jia
Bhaskar, Adithya
Finkelstein, Eric
Tong, Louis
author_facet Ozdemir, Semra
Yeo, Sharon Wan Jie
Lee, Jia Jia
Bhaskar, Adithya
Finkelstein, Eric
Tong, Louis
author_sort Ozdemir, Semra
collection PubMed
description OBJECTIVES: The side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and blurring) are important to patients compared to medication benefits or costs. METHODS: Patients diagnosed with DED were recruited at a referral eye center in Singapore (n = 139). This study utilized a Discrete Choice Experiment where patients were presented with 10 choice tasks where they were asked to choose between their current medication (or no medication), and two hypothetical medications that varied based on five attributes: duration of burning/stinging, duration of blurring, time to medication effectiveness, medication frequency, and out-of-pocket cost. The main outcomes were relative attribute importance and predicted uptake. RESULTS: Latent class logistic regressions found two groups with distinct preferences. For both classes, duration of burning/stinging (Class 1 = 23%, Class 2 = 29%) and cost (Class 1 = 24%, Class 2 = 27%) were the most important attributes while duration of blurring (Class 1 = 15%, Class 2 = 9%) was the least important. The predicted uptake of a medication increased 18 percentage-points when burning/stinging duration decreased from 2 h to a few minutes. The predicted uptake for new medications was lowest for those on medication with well-controlled symptoms and highest for those who were not on medication and could not control their symptoms effectively. CONCLUSION: This study showed that duration of burning/stinging was an important factor when choosing medications. Incorporating patient preferences in medication decisions can potentially improve patient acceptance of a treatment regimen. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40271-022-00586-8.
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spelling pubmed-91922512022-06-17 Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects Ozdemir, Semra Yeo, Sharon Wan Jie Lee, Jia Jia Bhaskar, Adithya Finkelstein, Eric Tong, Louis Patient Original Research Article OBJECTIVES: The side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and blurring) are important to patients compared to medication benefits or costs. METHODS: Patients diagnosed with DED were recruited at a referral eye center in Singapore (n = 139). This study utilized a Discrete Choice Experiment where patients were presented with 10 choice tasks where they were asked to choose between their current medication (or no medication), and two hypothetical medications that varied based on five attributes: duration of burning/stinging, duration of blurring, time to medication effectiveness, medication frequency, and out-of-pocket cost. The main outcomes were relative attribute importance and predicted uptake. RESULTS: Latent class logistic regressions found two groups with distinct preferences. For both classes, duration of burning/stinging (Class 1 = 23%, Class 2 = 29%) and cost (Class 1 = 24%, Class 2 = 27%) were the most important attributes while duration of blurring (Class 1 = 15%, Class 2 = 9%) was the least important. The predicted uptake of a medication increased 18 percentage-points when burning/stinging duration decreased from 2 h to a few minutes. The predicted uptake for new medications was lowest for those on medication with well-controlled symptoms and highest for those who were not on medication and could not control their symptoms effectively. CONCLUSION: This study showed that duration of burning/stinging was an important factor when choosing medications. Incorporating patient preferences in medication decisions can potentially improve patient acceptance of a treatment regimen. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40271-022-00586-8. Springer International Publishing 2022-06-14 2022 /pmc/articles/PMC9192251/ /pubmed/35697974 http://dx.doi.org/10.1007/s40271-022-00586-8 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Research Article
Ozdemir, Semra
Yeo, Sharon Wan Jie
Lee, Jia Jia
Bhaskar, Adithya
Finkelstein, Eric
Tong, Louis
Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects
title Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects
title_full Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects
title_fullStr Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects
title_full_unstemmed Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects
title_short Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects
title_sort patient medication preferences for managing dry eye disease: the importance of medication side effects
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192251/
https://www.ncbi.nlm.nih.gov/pubmed/35697974
http://dx.doi.org/10.1007/s40271-022-00586-8
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