Cargando…
Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats
In the present investigation, Ichnocarpus frutescens, Ficus dalhousiae, Crateva magna, Alpinia galanga, and Swertia chirata plants were selected to formulate polyherbal tea bag. The infusion obtained from these polyherbal tea bags was used to formulate 5% and 10% ointment formulation to perform its...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192309/ https://www.ncbi.nlm.nih.gov/pubmed/35707477 http://dx.doi.org/10.1155/2022/1372199 |
_version_ | 1784726210175041536 |
---|---|
author | Quazi, Aamir Patwekar, Mohsina Patwekar, Faheem Mezni, Amine Ahmad, Irfan Islam, Fahadul |
author_facet | Quazi, Aamir Patwekar, Mohsina Patwekar, Faheem Mezni, Amine Ahmad, Irfan Islam, Fahadul |
author_sort | Quazi, Aamir |
collection | PubMed |
description | In the present investigation, Ichnocarpus frutescens, Ficus dalhousiae, Crateva magna, Alpinia galanga, and Swertia chirata plants were selected to formulate polyherbal tea bag. The infusion obtained from these polyherbal tea bags was used to formulate 5% and 10% ointment formulation to perform its wound healing activity. The excision wound model was used to assess the wound healing activity in diabetic as well nondiabetic rats. The mean percentage closure of wound area was calculated on the 3(rd), 6(th), 9(th), 12(th), 15(th), 18(th), and finally 21(st) day. The wound healing activity of formulation was found to be significantly compared with that of the reference standard and untreated groups. The percentages of closure of excision wound area on the 21(st) day in diabetic animals treated with ointment formulations (F1 and F2) were found to be 93.91 ± 1.65% and 99.12 ± 5.21% respectively, whereas the chloramphenicol sodium drug solution was found to be 99.81 ± 3.16%. The percentages of closure of excision wound area in nondiabetic animals treated with ointment formulations (F1 and F2) were found to be 96.81 ± 2.04% and 98.13 ± 1.14%, respectively, whereas the chloramphenicol sodium drug solution was found to be 99.15 ± 1.41% at 21(st) day. Therefore, from the above results, we have concluded that this polyherbal ointment can be used clinically for the treatment of diabetic and nondiabetic wounds. |
format | Online Article Text |
id | pubmed-9192309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91923092022-06-14 Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats Quazi, Aamir Patwekar, Mohsina Patwekar, Faheem Mezni, Amine Ahmad, Irfan Islam, Fahadul Evid Based Complement Alternat Med Research Article In the present investigation, Ichnocarpus frutescens, Ficus dalhousiae, Crateva magna, Alpinia galanga, and Swertia chirata plants were selected to formulate polyherbal tea bag. The infusion obtained from these polyherbal tea bags was used to formulate 5% and 10% ointment formulation to perform its wound healing activity. The excision wound model was used to assess the wound healing activity in diabetic as well nondiabetic rats. The mean percentage closure of wound area was calculated on the 3(rd), 6(th), 9(th), 12(th), 15(th), 18(th), and finally 21(st) day. The wound healing activity of formulation was found to be significantly compared with that of the reference standard and untreated groups. The percentages of closure of excision wound area on the 21(st) day in diabetic animals treated with ointment formulations (F1 and F2) were found to be 93.91 ± 1.65% and 99.12 ± 5.21% respectively, whereas the chloramphenicol sodium drug solution was found to be 99.81 ± 3.16%. The percentages of closure of excision wound area in nondiabetic animals treated with ointment formulations (F1 and F2) were found to be 96.81 ± 2.04% and 98.13 ± 1.14%, respectively, whereas the chloramphenicol sodium drug solution was found to be 99.15 ± 1.41% at 21(st) day. Therefore, from the above results, we have concluded that this polyherbal ointment can be used clinically for the treatment of diabetic and nondiabetic wounds. Hindawi 2022-06-06 /pmc/articles/PMC9192309/ /pubmed/35707477 http://dx.doi.org/10.1155/2022/1372199 Text en Copyright © 2022 Aamir Quazi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Quazi, Aamir Patwekar, Mohsina Patwekar, Faheem Mezni, Amine Ahmad, Irfan Islam, Fahadul Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats |
title | Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats |
title_full | Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats |
title_fullStr | Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats |
title_full_unstemmed | Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats |
title_short | Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats |
title_sort | evaluation of wound healing activity (excision wound model) of ointment prepared from infusion extract of polyherbal tea bag formulation in diabetes-induced rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192309/ https://www.ncbi.nlm.nih.gov/pubmed/35707477 http://dx.doi.org/10.1155/2022/1372199 |
work_keys_str_mv | AT quaziaamir evaluationofwoundhealingactivityexcisionwoundmodelofointmentpreparedfrominfusionextractofpolyherbalteabagformulationindiabetesinducedrats AT patwekarmohsina evaluationofwoundhealingactivityexcisionwoundmodelofointmentpreparedfrominfusionextractofpolyherbalteabagformulationindiabetesinducedrats AT patwekarfaheem evaluationofwoundhealingactivityexcisionwoundmodelofointmentpreparedfrominfusionextractofpolyherbalteabagformulationindiabetesinducedrats AT mezniamine evaluationofwoundhealingactivityexcisionwoundmodelofointmentpreparedfrominfusionextractofpolyherbalteabagformulationindiabetesinducedrats AT ahmadirfan evaluationofwoundhealingactivityexcisionwoundmodelofointmentpreparedfrominfusionextractofpolyherbalteabagformulationindiabetesinducedrats AT islamfahadul evaluationofwoundhealingactivityexcisionwoundmodelofointmentpreparedfrominfusionextractofpolyherbalteabagformulationindiabetesinducedrats |