Cargando…

Evaluation of the Mechanism of Jiedu Huazhuo Quyu Formula in Treating Wilson's Disease-Associated Liver Fibrosis by Network Pharmacology Analysis and Molecular Dynamics Simulation

The Jiedu Huazhuo Quyu formula (JHQ) shows significant beneficial effects against liver fibrosis caused by Wilson's disease (WD). Hence, this study aimed to clarify the mechanisms of the JHQ treatment in WD-associated liver fibrosis. First, we collected 103 active compounds and 527 related targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Shao-Peng, Chen, Sen, Ma, Yan-Zhen, Zhou, An, Jiang, Hui, Wu, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192323/ https://www.ncbi.nlm.nih.gov/pubmed/35707473 http://dx.doi.org/10.1155/2022/9363131

Ejemplares similares

Potential Targets and Mechanisms of Jiedu Quyu Ziyin Decoction for Treating SLE-GIOP: Based on Network Pharmacology and Molecular Docking
por: Li, Jie, et al.
Publicado: (2023)

Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression
por: Ping, Xin, et al.
Publicado: (2019)

Quyu Shengji Formula Facilitates Diabetic Wound Healing via Inhibiting the Expression of Prostaglandin Transporter
por: Lu, Yi, et al.
Publicado: (2021)

Wenyang Huazhuo Tuihuang Formula Inhibits the Th17/Treg Cell Imbalance and Protects against Acute-on-Chronic Liver Failure
por: Wang, Xiufeng, et al.
Publicado: (2022)

Exploring the Mechanism of Wenshen Huatan Quyu Decotion for PCOS Based on Network Pharmacology and Molecular Docking Verification
por: Guo, Xin, et al.
Publicado: (2022)

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model
por: Wang, Qian, et al.
Publicado: (2018)

Anti-inflammation is an important way that Qingre-Huazhuo-Jiangsuan recipe treats acute gouty arthritis
por: Wang, Yazhuo, et al.
Publicado: (2023)

In Silico and In Vitro Studies on the Mechanisms of Chinese Medicine Formula (Yiqi Jianpi Jiedu Formula) in the Treatment of Hepatocellular Carcinoma
por: Wu, Zhulin, et al.
Publicado: (2022)

Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology
por: Gong, Zhaohui, et al.
Publicado: (2022)

Diagnostic Value of Serum Markers Combined with TVCDS in Ovarian Cancer Patients Treated with Bushen Yiqi Quyu Prescription
por: Qin, Wei, et al.
Publicado: (2021)

Network pharmacology-based prediction of active compounds in the Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo
por: Tang, Dan, et al.
Publicado: (2022)

Wenyang Huazhuo Tongluo formula alleviates pulmonary vascular injury and downregulates HIF-1α in bleomycin-induced systemic sclerosis mouse model
por: Li, Kai, et al.
Publicado: (2022)

Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
por: Yin, Xiangjun, et al.
Publicado: (2023)

Wenyang Huazhuo Tongluo formula, a Chinese herbal decoction, improves skin fibrosis by promoting apoptosis and inhibiting proliferation through down-regulation of survivin and cyclin D1 in systemic sclerosis
por: Han, Li, et al.
Publicado: (2016)

Decoding the chemical composition and pharmacological mechanisms of Jiedu Tongluo Tiaogan Formula using high-performance liquid chromatography coupled with network pharmacology-based investigation
por: Zhang, Qi, et al.
Publicado: (2021)

Decoding the Mechanism of Huanglian Jiedu Decoction in Treating Pneumonia Based on Network Pharmacology and Molecular Docking
por: Li, Xianhai, et al.
Publicado: (2021)

Corrigendum: Network pharmacology-based prediction of active compounds in Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo
por: Tang, Dan, et al.
Publicado: (2022)

Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure
por: Li, Xuan, et al.
Publicado: (2022)

JianPi HuaZhuo XingNao formula (Chinese herbal medicine) for the treatment of minimal hepatic encephalopathy: a protocol for a randomized, placebo-controlled pilot trial
por: Li, XiaoKe, et al.
Publicado: (2018)

Jiedu-Yizhi Formula Alleviates Neuroinflammation in AD Rats by Modulating the Gut Microbiota
por: Wang, Jiale, et al.
Publicado: (2022)

Evaluation of liver fibrosis in patients with Wilson’s disease
por: Przybyłkowski, Adam, et al.
Publicado: (2020)

Molecular mechanisms of Huanglian jiedu decoction on ulcerative colitis based on network pharmacology and molecular docking
por: Yang, Jing, et al.
Publicado: (2022)

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis
por: Liang, Jiahua, et al.
Publicado: (2021)

Network Pharmacology Interpretation of Fuzheng–Jiedu Decoction against Colorectal Cancer
por: Shi, Hongshuo, et al.
Publicado: (2021)

Molecular targets of Yangyin Fuzheng Jiedu Prescription in the treatment of hepatocellular carcinoma based on network pharmacology analysis
por: Yan, Fengna, et al.
Publicado: (2020)

Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trial
por: Xu, Jinghan, et al.
Publicado: (2022)

Exploring the Active Ingredients and Mechanism of Action of Huanglian Huazhuo Capsule for the Treatment of Obese Type-2 Diabetes Mellitus Based on Using Network Pharmacology and Molecular Docking
por: Wang, Na, et al.
Publicado: (2022)

Treatment of liver fibrosis in hepatolenticular degeneration with traditional Chinese medicine: systematic review of meta-analysis, network pharmacology and molecular dynamics simulation
por: Yang, Xulong, et al.
Publicado: (2023)

Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway
por: Li, Hangchao, et al.
Publicado: (2022)

Network pharmacology and molecular docking analysis on molecular targets and mechanism prediction of Huanglian Jiedu Decoction in the treatment of COVID-19
por: Xinyi, Xu, et al.
Publicado: (2022)

Stimulation of Liver Fibrosis by N2 Neutrophils in Wilson’s Disease
por: Mi, Xiaoxiao, et al.
Publicado: (2023)

Study on Intervention Mechanism of Yiqi Huayu Jiedu Decoction on ARDS Based on Network Pharmacology
por: Liang, Xu, et al.
Publicado: (2020)

Mechanisms and network pharmacological analysis of Yangyin Fuzheng Jiedu prescription in the treatment of hepatocellular carcinoma
por: Xie, Yuqing, et al.
Publicado: (2022)

A Network Pharmacology Approach to Explore the Mechanisms of Shugan Jianpi Formula in Liver Fibrosis
por: Fan, Chang, et al.
Publicado: (2020)

Molecular mechanisms of Huanglian Jiedu decoction in treating Alzheimer’s disease by regulating microbiome via network pharmacology and molecular docking analysis
por: Zheng, Renyuan, et al.
Publicado: (2023)

Pharmacological mechanisms of Fuzheng Huayu formula for Aristolochic acid I–induced kidney fibrosis through network pharmacology
por: Wang, Fan, et al.
Publicado: (2022)

Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy
por: Cao, Xu, et al.
Publicado: (2022)

Therapeutic Effects and Associated Mechanisms by which “Fuyang Jiedu Huayu” Granules Treat Chronic Liver Failure in the Rat
por: Ye, Qianling, et al.
Publicado: (2021)

Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools
por: Xiong, Haijun, et al.
Publicado: (2020)

Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan-Niwan Formula Treating Acute-on-Chronic Liver Failure
por: Liang, Jiajun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a8vaqams5kju91f47k02ef079u