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Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation

During translation initiation, initiation factor 2 (IF2) holds initiator transfer RNA (fMet-tRNA(i)(fMet)) in a specific orientation in the peptidyl (P) site of the ribosome. Upon subunit joining IF2 hydrolyzes GTP and, concomitant with inorganic phosphate (P(i)) release, changes conformation facili...

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Detalles Bibliográficos
Autores principales:	Basu, Ritwika S., Sherman, Michael B., Gagnon, Matthieu G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192638/ https://www.ncbi.nlm.nih.gov/pubmed/35697706 http://dx.doi.org/10.1038/s41467-022-31129-2

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