Using directional OCT to analyze photoreceptor visibility over AMD-related drusen

Investigators have reported reduced visibility of the cone photoreceptors overlying drusen using adaptive optics (AO) imaging techniques. Two hypotheses have been proposed to explain this phenomenon. First, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its abilit...

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Autores principales: Marsh-Armstrong, Brennan, Murrell, Kelly S., Valente, Denise, Jonnal, Ravi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192709/
https://www.ncbi.nlm.nih.gov/pubmed/35697705
http://dx.doi.org/10.1038/s41598-022-13106-3
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author Marsh-Armstrong, Brennan
Murrell, Kelly S.
Valente, Denise
Jonnal, Ravi S.
author_facet Marsh-Armstrong, Brennan
Murrell, Kelly S.
Valente, Denise
Jonnal, Ravi S.
author_sort Marsh-Armstrong, Brennan
collection PubMed
description Investigators have reported reduced visibility of the cone photoreceptors overlying drusen using adaptive optics (AO) imaging techniques. Two hypotheses have been proposed to explain this phenomenon. First, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its ability to act as a wave guide, thus decreasing the cell’s familiar reflectance pattern. Second, drusen could disorient the photoreceptors away from the eye’s pupil, reducing the amount of light reflected back out the pupil. In this work, we use directional OCT (dOCT) images of drusen in AMD patients to measure the respective contributions of these deforming and disorienting factors.
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spelling pubmed-91927092022-06-15 Using directional OCT to analyze photoreceptor visibility over AMD-related drusen Marsh-Armstrong, Brennan Murrell, Kelly S. Valente, Denise Jonnal, Ravi S. Sci Rep Article Investigators have reported reduced visibility of the cone photoreceptors overlying drusen using adaptive optics (AO) imaging techniques. Two hypotheses have been proposed to explain this phenomenon. First, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its ability to act as a wave guide, thus decreasing the cell’s familiar reflectance pattern. Second, drusen could disorient the photoreceptors away from the eye’s pupil, reducing the amount of light reflected back out the pupil. In this work, we use directional OCT (dOCT) images of drusen in AMD patients to measure the respective contributions of these deforming and disorienting factors. Nature Publishing Group UK 2022-06-13 /pmc/articles/PMC9192709/ /pubmed/35697705 http://dx.doi.org/10.1038/s41598-022-13106-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Marsh-Armstrong, Brennan
Murrell, Kelly S.
Valente, Denise
Jonnal, Ravi S.
Using directional OCT to analyze photoreceptor visibility over AMD-related drusen
title Using directional OCT to analyze photoreceptor visibility over AMD-related drusen
title_full Using directional OCT to analyze photoreceptor visibility over AMD-related drusen
title_fullStr Using directional OCT to analyze photoreceptor visibility over AMD-related drusen
title_full_unstemmed Using directional OCT to analyze photoreceptor visibility over AMD-related drusen
title_short Using directional OCT to analyze photoreceptor visibility over AMD-related drusen
title_sort using directional oct to analyze photoreceptor visibility over amd-related drusen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192709/
https://www.ncbi.nlm.nih.gov/pubmed/35697705
http://dx.doi.org/10.1038/s41598-022-13106-3
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