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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for indivi...

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Detalles Bibliográficos
Autores principales: Winkler, Thomas W., Rasheed, Humaira, Teumer, Alexander, Gorski, Mathias, Rowan, Bryce X., Stanzick, Kira J., Thomas, Laurent F., Tin, Adrienne, Hoppmann, Anselm, Chu, Audrey Y., Tayo, Bamidele, Thio, Chris H. L., Cusi, Daniele, Chai, Jin-Fang, Sieber, Karsten B., Horn, Katrin, Li, Man, Scholz, Markus, Cocca, Massimiliano, Wuttke, Matthias, van der Most, Peter J., Yang, Qiong, Ghasemi, Sahar, Nutile, Teresa, Li, Yong, Pontali, Giulia, Günther, Felix, Dehghan, Abbas, Correa, Adolfo, Parsa, Afshin, Feresin, Agnese, de Vries, Aiko P. J., Zonderman, Alan B., Smith, Albert V., Oldehinkel, Albertine J., De Grandi, Alessandro, Rosenkranz, Alexander R., Franke, Andre, Teren, Andrej, Metspalu, Andres, Hicks, Andrew A., Morris, Andrew P., Tönjes, Anke, Morgan, Anna, Podgornaia, Anna I., Peters, Annette, Körner, Antje, Mahajan, Anubha, Campbell, Archie, Freedman, Barry I., Spedicati, Beatrice, Ponte, Belen, Schöttker, Ben, Brumpton, Ben, Banas, Bernhard, Krämer, Bernhard K., Jung, Bettina, Åsvold, Bjørn Olav, Smith, Blair H., Ning, Boting, Penninx, Brenda W. J. H., Vanderwerff, Brett R., Psaty, Bruce M., Kammerer, Candace M., Langefeld, Carl D., Hayward, Caroline, Spracklen, Cassandra N., Robinson-Cohen, Cassianne, Hartman, Catharina A., Lindgren, Cecilia M., Wang, Chaolong, Sabanayagam, Charumathi, Heng, Chew-Kiat, Lanzani, Chiara, Khor, Chiea-Chuen, Cheng, Ching-Yu, Fuchsberger, Christian, Gieger, Christian, Shaffer, Christian M., Schulz, Christina-Alexandra, Willer, Cristen J., Chasman, Daniel I., Gudbjartsson, Daniel F., Ruggiero, Daniela, Toniolo, Daniela, Czamara, Darina, Porteous, David J., Waterworth, Dawn M., Mascalzoni, Deborah, Mook-Kanamori, Dennis O., Reilly, Dermot F., Daw, E. Warwick, Hofer, Edith, Boerwinkle, Eric, Salvi, Erika, Bottinger, Erwin P., Tai, E-Shyong, Catamo, Eulalia, Rizzi, Federica, Guo, Feng, Rivadeneira, Fernando, Guilianini, Franco, Sveinbjornsson, Gardar, Ehret, Georg, Waeber, Gerard, Biino, Ginevra, Girotto, Giorgia, Pistis, Giorgio, Nadkarni, Girish N., Delgado, Graciela E., Montgomery, Grant W., Snieder, Harold, Campbell, Harry, White, Harvey D., Gao, He, Stringham, Heather M., Schmidt, Helena, Li, Hengtong, Brenner, Hermann, Holm, Hilma, Kirsten, Holgen, Kramer, Holly, Rudan, Igor, Nolte, Ilja M., Tzoulaki, Ioanna, Olafsson, Isleifur, Martins, Jade, Cook, James P., Wilson, James F., Halbritter, Jan, Felix, Janine F., Divers, Jasmin, Kooner, Jaspal S., Lee, Jeannette Jen-Mai, O’Connell, Jeffrey, Rotter, Jerome I., Liu, Jianjun, Xu, Jie, Thiery, Joachim, Ärnlöv, Johan, Kuusisto, Johanna, Jakobsdottir, Johanna, Tremblay, Johanne, Chambers, John C., Whitfield, John B., Gaziano, John M., Marten, Jonathan, Coresh, Josef, Jonas, Jost B., Mychaleckyj, Josyf C., Christensen, Kaare, Eckardt, Kai-Uwe, Mohlke, Karen L., Endlich, Karlhans, Dittrich, Katalin, Ryan, Kathleen A., Rice, Kenneth M., Taylor, Kent D., Ho, Kevin, Nikus, Kjell, Matsuda, Koichi, Strauch, Konstantin, Miliku, Kozeta, Hveem, Kristian, Lind, Lars, Wallentin, Lars, Yerges-Armstrong, Laura M., Raffield, Laura M., Phillips, Lawrence S., Launer, Lenore J., Lyytikäinen, Leo-Pekka, Lange, Leslie A., Citterio, Lorena, Klaric, Lucija, Ikram, M. Arfan, Ising, Marcus, Kleber, Marcus E., Francescatto, Margherita, Concas, Maria Pina, Ciullo, Marina, Piratsu, Mario, Orho-Melander, Marju, Laakso, Markku, Loeffler, Markus, Perola, Markus, de Borst, Martin H., Gögele, Martin, Bianca, Martina La, Lukas, Mary Ann, Feitosa, Mary F., Biggs, Mary L., Wojczynski, Mary K., Kavousi, Maryam, Kanai, Masahiro, Akiyama, Masato, Yasuda, Masayuki, Nauck, Matthias, Waldenberger, Melanie, Chee, Miao-Li, Chee, Miao-Ling, Boehnke, Michael, Preuss, Michael H., Stumvoll, Michael, Province, Michael A., Evans, Michele K., O’Donoghue, Michelle L., Kubo, Michiaki, Kähönen, Mika, Kastarinen, Mika, Nalls, Mike A., Kuokkanen, Mikko, Ghanbari, Mohsen, Bochud, Murielle, Josyula, Navya Shilpa, Martin, Nicholas G., Tan, Nicholas Y. Q., Palmer, Nicholette D., Pirastu, Nicola, Schupf, Nicole, Verweij, Niek, Hutri-Kähönen, Nina, Mononen, Nina, Bansal, Nisha, Devuyst, Olivier, Melander, Olle, Raitakari, Olli T., Polasek, Ozren, Manunta, Paolo, Gasparini, Paolo, Mishra, Pashupati P., Sulem, Patrick, Magnusson, Patrik K. E., Elliott, Paul, Ridker, Paul M., Hamet, Pavel, Svensson, Per O., Joshi, Peter K., Kovacs, Peter, Pramstaller, Peter P., Rossing, Peter, Vollenweider, Peter, van der Harst, Pim, Dorajoo, Rajkumar, Sim, Ralene Z. H., Burkhardt, Ralph, Tao, Ran, Noordam, Raymond, Mägi, Reedik, Schmidt, Reinhold, de Mutsert, Renée, Rueedi, Rico, van Dam, Rob M., Carroll, Robert J., Gansevoort, Ron T., Loos, Ruth J. F., Felicita, Sala Cinzia, Sedaghat, Sanaz, Padmanabhan, Sandosh, Freitag-Wolf, Sandra, Pendergrass, Sarah A., Graham, Sarah E., Gordon, Scott D., Hwang, Shih-Jen, Kerr, Shona M., Vaccargiu, Simona, Patil, Snehal B., Hallan, Stein, Bakker, Stephan J. L., Lim, Su-Chi, Lucae, Susanne, Vogelezang, Suzanne, Bergmann, Sven, Corre, Tanguy, Ahluwalia, Tarunveer S., Lehtimäki, Terho, Boutin, Thibaud S., Meitinger, Thomas, Wong, Tien-Yin, Bergler, Tobias, Rabelink, Ton J., Esko, Tõnu, Haller, Toomas, Thorsteinsdottir, Unnur, Völker, Uwe, Foo, Valencia Hui Xian, Salomaa, Veikko, Vitart, Veronique, Giedraitis, Vilmantas, Gudnason, Vilmundur, Jaddoe, Vincent W. V., Huang, Wei, Zhang, Weihua, Wei, Wen Bin, Kiess, Wieland, März, Winfried, Koenig, Wolfgang, Lieb, Wolfgang, Gao, Xin, Sim, Xueling, Wang, Ya Xing, Friedlander, Yechiel, Tham, Yih-Chung, Kamatani, Yoichiro, Okada, Yukinori, Milaneschi, Yuri, Yu, Zhi, Stark, Klaus J., Stefansson, Kari, Böger, Carsten A., Hung, Adriana M., Kronenberg, Florian, Köttgen, Anna, Pattaro, Cristian, Heid, Iris M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192715/
https://www.ncbi.nlm.nih.gov/pubmed/35697829
http://dx.doi.org/10.1038/s42003-022-03448-z
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author Winkler, Thomas W.
Rasheed, Humaira
Teumer, Alexander
Gorski, Mathias
Rowan, Bryce X.
Stanzick, Kira J.
Thomas, Laurent F.
Tin, Adrienne
Hoppmann, Anselm
Chu, Audrey Y.
Tayo, Bamidele
Thio, Chris H. L.
Cusi, Daniele
Chai, Jin-Fang
Sieber, Karsten B.
Horn, Katrin
Li, Man
Scholz, Markus
Cocca, Massimiliano
Wuttke, Matthias
van der Most, Peter J.
Yang, Qiong
Ghasemi, Sahar
Nutile, Teresa
Li, Yong
Pontali, Giulia
Günther, Felix
Dehghan, Abbas
Correa, Adolfo
Parsa, Afshin
Feresin, Agnese
de Vries, Aiko P. J.
Zonderman, Alan B.
Smith, Albert V.
Oldehinkel, Albertine J.
De Grandi, Alessandro
Rosenkranz, Alexander R.
Franke, Andre
Teren, Andrej
Metspalu, Andres
Hicks, Andrew A.
Morris, Andrew P.
Tönjes, Anke
Morgan, Anna
Podgornaia, Anna I.
Peters, Annette
Körner, Antje
Mahajan, Anubha
Campbell, Archie
Freedman, Barry I.
Spedicati, Beatrice
Ponte, Belen
Schöttker, Ben
Brumpton, Ben
Banas, Bernhard
Krämer, Bernhard K.
Jung, Bettina
Åsvold, Bjørn Olav
Smith, Blair H.
Ning, Boting
Penninx, Brenda W. J. H.
Vanderwerff, Brett R.
Psaty, Bruce M.
Kammerer, Candace M.
Langefeld, Carl D.
Hayward, Caroline
Spracklen, Cassandra N.
Robinson-Cohen, Cassianne
Hartman, Catharina A.
Lindgren, Cecilia M.
Wang, Chaolong
Sabanayagam, Charumathi
Heng, Chew-Kiat
Lanzani, Chiara
Khor, Chiea-Chuen
Cheng, Ching-Yu
Fuchsberger, Christian
Gieger, Christian
Shaffer, Christian M.
Schulz, Christina-Alexandra
Willer, Cristen J.
Chasman, Daniel I.
Gudbjartsson, Daniel F.
Ruggiero, Daniela
Toniolo, Daniela
Czamara, Darina
Porteous, David J.
Waterworth, Dawn M.
Mascalzoni, Deborah
Mook-Kanamori, Dennis O.
Reilly, Dermot F.
Daw, E. Warwick
Hofer, Edith
Boerwinkle, Eric
Salvi, Erika
Bottinger, Erwin P.
Tai, E-Shyong
Catamo, Eulalia
Rizzi, Federica
Guo, Feng
Rivadeneira, Fernando
Guilianini, Franco
Sveinbjornsson, Gardar
Ehret, Georg
Waeber, Gerard
Biino, Ginevra
Girotto, Giorgia
Pistis, Giorgio
Nadkarni, Girish N.
Delgado, Graciela E.
Montgomery, Grant W.
Snieder, Harold
Campbell, Harry
White, Harvey D.
Gao, He
Stringham, Heather M.
Schmidt, Helena
Li, Hengtong
Brenner, Hermann
Holm, Hilma
Kirsten, Holgen
Kramer, Holly
Rudan, Igor
Nolte, Ilja M.
Tzoulaki, Ioanna
Olafsson, Isleifur
Martins, Jade
Cook, James P.
Wilson, James F.
Halbritter, Jan
Felix, Janine F.
Divers, Jasmin
Kooner, Jaspal S.
Lee, Jeannette Jen-Mai
O’Connell, Jeffrey
Rotter, Jerome I.
Liu, Jianjun
Xu, Jie
Thiery, Joachim
Ärnlöv, Johan
Kuusisto, Johanna
Jakobsdottir, Johanna
Tremblay, Johanne
Chambers, John C.
Whitfield, John B.
Gaziano, John M.
Marten, Jonathan
Coresh, Josef
Jonas, Jost B.
Mychaleckyj, Josyf C.
Christensen, Kaare
Eckardt, Kai-Uwe
Mohlke, Karen L.
Endlich, Karlhans
Dittrich, Katalin
Ryan, Kathleen A.
Rice, Kenneth M.
Taylor, Kent D.
Ho, Kevin
Nikus, Kjell
Matsuda, Koichi
Strauch, Konstantin
Miliku, Kozeta
Hveem, Kristian
Lind, Lars
Wallentin, Lars
Yerges-Armstrong, Laura M.
Raffield, Laura M.
Phillips, Lawrence S.
Launer, Lenore J.
Lyytikäinen, Leo-Pekka
Lange, Leslie A.
Citterio, Lorena
Klaric, Lucija
Ikram, M. Arfan
Ising, Marcus
Kleber, Marcus E.
Francescatto, Margherita
Concas, Maria Pina
Ciullo, Marina
Piratsu, Mario
Orho-Melander, Marju
Laakso, Markku
Loeffler, Markus
Perola, Markus
de Borst, Martin H.
Gögele, Martin
Bianca, Martina La
Lukas, Mary Ann
Feitosa, Mary F.
Biggs, Mary L.
Wojczynski, Mary K.
Kavousi, Maryam
Kanai, Masahiro
Akiyama, Masato
Yasuda, Masayuki
Nauck, Matthias
Waldenberger, Melanie
Chee, Miao-Li
Chee, Miao-Ling
Boehnke, Michael
Preuss, Michael H.
Stumvoll, Michael
Province, Michael A.
Evans, Michele K.
O’Donoghue, Michelle L.
Kubo, Michiaki
Kähönen, Mika
Kastarinen, Mika
Nalls, Mike A.
Kuokkanen, Mikko
Ghanbari, Mohsen
Bochud, Murielle
Josyula, Navya Shilpa
Martin, Nicholas G.
Tan, Nicholas Y. Q.
Palmer, Nicholette D.
Pirastu, Nicola
Schupf, Nicole
Verweij, Niek
Hutri-Kähönen, Nina
Mononen, Nina
Bansal, Nisha
Devuyst, Olivier
Melander, Olle
Raitakari, Olli T.
Polasek, Ozren
Manunta, Paolo
Gasparini, Paolo
Mishra, Pashupati P.
Sulem, Patrick
Magnusson, Patrik K. E.
Elliott, Paul
Ridker, Paul M.
Hamet, Pavel
Svensson, Per O.
Joshi, Peter K.
Kovacs, Peter
Pramstaller, Peter P.
Rossing, Peter
Vollenweider, Peter
van der Harst, Pim
Dorajoo, Rajkumar
Sim, Ralene Z. H.
Burkhardt, Ralph
Tao, Ran
Noordam, Raymond
Mägi, Reedik
Schmidt, Reinhold
de Mutsert, Renée
Rueedi, Rico
van Dam, Rob M.
Carroll, Robert J.
Gansevoort, Ron T.
Loos, Ruth J. F.
Felicita, Sala Cinzia
Sedaghat, Sanaz
Padmanabhan, Sandosh
Freitag-Wolf, Sandra
Pendergrass, Sarah A.
Graham, Sarah E.
Gordon, Scott D.
Hwang, Shih-Jen
Kerr, Shona M.
Vaccargiu, Simona
Patil, Snehal B.
Hallan, Stein
Bakker, Stephan J. L.
Lim, Su-Chi
Lucae, Susanne
Vogelezang, Suzanne
Bergmann, Sven
Corre, Tanguy
Ahluwalia, Tarunveer S.
Lehtimäki, Terho
Boutin, Thibaud S.
Meitinger, Thomas
Wong, Tien-Yin
Bergler, Tobias
Rabelink, Ton J.
Esko, Tõnu
Haller, Toomas
Thorsteinsdottir, Unnur
Völker, Uwe
Foo, Valencia Hui Xian
Salomaa, Veikko
Vitart, Veronique
Giedraitis, Vilmantas
Gudnason, Vilmundur
Jaddoe, Vincent W. V.
Huang, Wei
Zhang, Weihua
Wei, Wen Bin
Kiess, Wieland
März, Winfried
Koenig, Wolfgang
Lieb, Wolfgang
Gao, Xin
Sim, Xueling
Wang, Ya Xing
Friedlander, Yechiel
Tham, Yih-Chung
Kamatani, Yoichiro
Okada, Yukinori
Milaneschi, Yuri
Yu, Zhi
Stark, Klaus J.
Stefansson, Kari
Böger, Carsten A.
Hung, Adriana M.
Kronenberg, Florian
Köttgen, Anna
Pattaro, Cristian
Heid, Iris M.
author_facet Winkler, Thomas W.
Rasheed, Humaira
Teumer, Alexander
Gorski, Mathias
Rowan, Bryce X.
Stanzick, Kira J.
Thomas, Laurent F.
Tin, Adrienne
Hoppmann, Anselm
Chu, Audrey Y.
Tayo, Bamidele
Thio, Chris H. L.
Cusi, Daniele
Chai, Jin-Fang
Sieber, Karsten B.
Horn, Katrin
Li, Man
Scholz, Markus
Cocca, Massimiliano
Wuttke, Matthias
van der Most, Peter J.
Yang, Qiong
Ghasemi, Sahar
Nutile, Teresa
Li, Yong
Pontali, Giulia
Günther, Felix
Dehghan, Abbas
Correa, Adolfo
Parsa, Afshin
Feresin, Agnese
de Vries, Aiko P. J.
Zonderman, Alan B.
Smith, Albert V.
Oldehinkel, Albertine J.
De Grandi, Alessandro
Rosenkranz, Alexander R.
Franke, Andre
Teren, Andrej
Metspalu, Andres
Hicks, Andrew A.
Morris, Andrew P.
Tönjes, Anke
Morgan, Anna
Podgornaia, Anna I.
Peters, Annette
Körner, Antje
Mahajan, Anubha
Campbell, Archie
Freedman, Barry I.
Spedicati, Beatrice
Ponte, Belen
Schöttker, Ben
Brumpton, Ben
Banas, Bernhard
Krämer, Bernhard K.
Jung, Bettina
Åsvold, Bjørn Olav
Smith, Blair H.
Ning, Boting
Penninx, Brenda W. J. H.
Vanderwerff, Brett R.
Psaty, Bruce M.
Kammerer, Candace M.
Langefeld, Carl D.
Hayward, Caroline
Spracklen, Cassandra N.
Robinson-Cohen, Cassianne
Hartman, Catharina A.
Lindgren, Cecilia M.
Wang, Chaolong
Sabanayagam, Charumathi
Heng, Chew-Kiat
Lanzani, Chiara
Khor, Chiea-Chuen
Cheng, Ching-Yu
Fuchsberger, Christian
Gieger, Christian
Shaffer, Christian M.
Schulz, Christina-Alexandra
Willer, Cristen J.
Chasman, Daniel I.
Gudbjartsson, Daniel F.
Ruggiero, Daniela
Toniolo, Daniela
Czamara, Darina
Porteous, David J.
Waterworth, Dawn M.
Mascalzoni, Deborah
Mook-Kanamori, Dennis O.
Reilly, Dermot F.
Daw, E. Warwick
Hofer, Edith
Boerwinkle, Eric
Salvi, Erika
Bottinger, Erwin P.
Tai, E-Shyong
Catamo, Eulalia
Rizzi, Federica
Guo, Feng
Rivadeneira, Fernando
Guilianini, Franco
Sveinbjornsson, Gardar
Ehret, Georg
Waeber, Gerard
Biino, Ginevra
Girotto, Giorgia
Pistis, Giorgio
Nadkarni, Girish N.
Delgado, Graciela E.
Montgomery, Grant W.
Snieder, Harold
Campbell, Harry
White, Harvey D.
Gao, He
Stringham, Heather M.
Schmidt, Helena
Li, Hengtong
Brenner, Hermann
Holm, Hilma
Kirsten, Holgen
Kramer, Holly
Rudan, Igor
Nolte, Ilja M.
Tzoulaki, Ioanna
Olafsson, Isleifur
Martins, Jade
Cook, James P.
Wilson, James F.
Halbritter, Jan
Felix, Janine F.
Divers, Jasmin
Kooner, Jaspal S.
Lee, Jeannette Jen-Mai
O’Connell, Jeffrey
Rotter, Jerome I.
Liu, Jianjun
Xu, Jie
Thiery, Joachim
Ärnlöv, Johan
Kuusisto, Johanna
Jakobsdottir, Johanna
Tremblay, Johanne
Chambers, John C.
Whitfield, John B.
Gaziano, John M.
Marten, Jonathan
Coresh, Josef
Jonas, Jost B.
Mychaleckyj, Josyf C.
Christensen, Kaare
Eckardt, Kai-Uwe
Mohlke, Karen L.
Endlich, Karlhans
Dittrich, Katalin
Ryan, Kathleen A.
Rice, Kenneth M.
Taylor, Kent D.
Ho, Kevin
Nikus, Kjell
Matsuda, Koichi
Strauch, Konstantin
Miliku, Kozeta
Hveem, Kristian
Lind, Lars
Wallentin, Lars
Yerges-Armstrong, Laura M.
Raffield, Laura M.
Phillips, Lawrence S.
Launer, Lenore J.
Lyytikäinen, Leo-Pekka
Lange, Leslie A.
Citterio, Lorena
Klaric, Lucija
Ikram, M. Arfan
Ising, Marcus
Kleber, Marcus E.
Francescatto, Margherita
Concas, Maria Pina
Ciullo, Marina
Piratsu, Mario
Orho-Melander, Marju
Laakso, Markku
Loeffler, Markus
Perola, Markus
de Borst, Martin H.
Gögele, Martin
Bianca, Martina La
Lukas, Mary Ann
Feitosa, Mary F.
Biggs, Mary L.
Wojczynski, Mary K.
Kavousi, Maryam
Kanai, Masahiro
Akiyama, Masato
Yasuda, Masayuki
Nauck, Matthias
Waldenberger, Melanie
Chee, Miao-Li
Chee, Miao-Ling
Boehnke, Michael
Preuss, Michael H.
Stumvoll, Michael
Province, Michael A.
Evans, Michele K.
O’Donoghue, Michelle L.
Kubo, Michiaki
Kähönen, Mika
Kastarinen, Mika
Nalls, Mike A.
Kuokkanen, Mikko
Ghanbari, Mohsen
Bochud, Murielle
Josyula, Navya Shilpa
Martin, Nicholas G.
Tan, Nicholas Y. Q.
Palmer, Nicholette D.
Pirastu, Nicola
Schupf, Nicole
Verweij, Niek
Hutri-Kähönen, Nina
Mononen, Nina
Bansal, Nisha
Devuyst, Olivier
Melander, Olle
Raitakari, Olli T.
Polasek, Ozren
Manunta, Paolo
Gasparini, Paolo
Mishra, Pashupati P.
Sulem, Patrick
Magnusson, Patrik K. E.
Elliott, Paul
Ridker, Paul M.
Hamet, Pavel
Svensson, Per O.
Joshi, Peter K.
Kovacs, Peter
Pramstaller, Peter P.
Rossing, Peter
Vollenweider, Peter
van der Harst, Pim
Dorajoo, Rajkumar
Sim, Ralene Z. H.
Burkhardt, Ralph
Tao, Ran
Noordam, Raymond
Mägi, Reedik
Schmidt, Reinhold
de Mutsert, Renée
Rueedi, Rico
van Dam, Rob M.
Carroll, Robert J.
Gansevoort, Ron T.
Loos, Ruth J. F.
Felicita, Sala Cinzia
Sedaghat, Sanaz
Padmanabhan, Sandosh
Freitag-Wolf, Sandra
Pendergrass, Sarah A.
Graham, Sarah E.
Gordon, Scott D.
Hwang, Shih-Jen
Kerr, Shona M.
Vaccargiu, Simona
Patil, Snehal B.
Hallan, Stein
Bakker, Stephan J. L.
Lim, Su-Chi
Lucae, Susanne
Vogelezang, Suzanne
Bergmann, Sven
Corre, Tanguy
Ahluwalia, Tarunveer S.
Lehtimäki, Terho
Boutin, Thibaud S.
Meitinger, Thomas
Wong, Tien-Yin
Bergler, Tobias
Rabelink, Ton J.
Esko, Tõnu
Haller, Toomas
Thorsteinsdottir, Unnur
Völker, Uwe
Foo, Valencia Hui Xian
Salomaa, Veikko
Vitart, Veronique
Giedraitis, Vilmantas
Gudnason, Vilmundur
Jaddoe, Vincent W. V.
Huang, Wei
Zhang, Weihua
Wei, Wen Bin
Kiess, Wieland
März, Winfried
Koenig, Wolfgang
Lieb, Wolfgang
Gao, Xin
Sim, Xueling
Wang, Ya Xing
Friedlander, Yechiel
Tham, Yih-Chung
Kamatani, Yoichiro
Okada, Yukinori
Milaneschi, Yuri
Yu, Zhi
Stark, Klaus J.
Stefansson, Kari
Böger, Carsten A.
Hung, Adriana M.
Kronenberg, Florian
Köttgen, Anna
Pattaro, Cristian
Heid, Iris M.
author_sort Winkler, Thomas W.
collection PubMed
description Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
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spelling pubmed-91927152022-06-15 Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals Winkler, Thomas W. Rasheed, Humaira Teumer, Alexander Gorski, Mathias Rowan, Bryce X. Stanzick, Kira J. Thomas, Laurent F. Tin, Adrienne Hoppmann, Anselm Chu, Audrey Y. Tayo, Bamidele Thio, Chris H. L. Cusi, Daniele Chai, Jin-Fang Sieber, Karsten B. Horn, Katrin Li, Man Scholz, Markus Cocca, Massimiliano Wuttke, Matthias van der Most, Peter J. Yang, Qiong Ghasemi, Sahar Nutile, Teresa Li, Yong Pontali, Giulia Günther, Felix Dehghan, Abbas Correa, Adolfo Parsa, Afshin Feresin, Agnese de Vries, Aiko P. J. Zonderman, Alan B. Smith, Albert V. Oldehinkel, Albertine J. De Grandi, Alessandro Rosenkranz, Alexander R. Franke, Andre Teren, Andrej Metspalu, Andres Hicks, Andrew A. Morris, Andrew P. Tönjes, Anke Morgan, Anna Podgornaia, Anna I. Peters, Annette Körner, Antje Mahajan, Anubha Campbell, Archie Freedman, Barry I. Spedicati, Beatrice Ponte, Belen Schöttker, Ben Brumpton, Ben Banas, Bernhard Krämer, Bernhard K. Jung, Bettina Åsvold, Bjørn Olav Smith, Blair H. Ning, Boting Penninx, Brenda W. J. H. Vanderwerff, Brett R. Psaty, Bruce M. Kammerer, Candace M. Langefeld, Carl D. Hayward, Caroline Spracklen, Cassandra N. Robinson-Cohen, Cassianne Hartman, Catharina A. Lindgren, Cecilia M. Wang, Chaolong Sabanayagam, Charumathi Heng, Chew-Kiat Lanzani, Chiara Khor, Chiea-Chuen Cheng, Ching-Yu Fuchsberger, Christian Gieger, Christian Shaffer, Christian M. Schulz, Christina-Alexandra Willer, Cristen J. Chasman, Daniel I. Gudbjartsson, Daniel F. Ruggiero, Daniela Toniolo, Daniela Czamara, Darina Porteous, David J. Waterworth, Dawn M. Mascalzoni, Deborah Mook-Kanamori, Dennis O. Reilly, Dermot F. Daw, E. Warwick Hofer, Edith Boerwinkle, Eric Salvi, Erika Bottinger, Erwin P. Tai, E-Shyong Catamo, Eulalia Rizzi, Federica Guo, Feng Rivadeneira, Fernando Guilianini, Franco Sveinbjornsson, Gardar Ehret, Georg Waeber, Gerard Biino, Ginevra Girotto, Giorgia Pistis, Giorgio Nadkarni, Girish N. Delgado, Graciela E. Montgomery, Grant W. Snieder, Harold Campbell, Harry White, Harvey D. Gao, He Stringham, Heather M. Schmidt, Helena Li, Hengtong Brenner, Hermann Holm, Hilma Kirsten, Holgen Kramer, Holly Rudan, Igor Nolte, Ilja M. Tzoulaki, Ioanna Olafsson, Isleifur Martins, Jade Cook, James P. Wilson, James F. Halbritter, Jan Felix, Janine F. Divers, Jasmin Kooner, Jaspal S. Lee, Jeannette Jen-Mai O’Connell, Jeffrey Rotter, Jerome I. Liu, Jianjun Xu, Jie Thiery, Joachim Ärnlöv, Johan Kuusisto, Johanna Jakobsdottir, Johanna Tremblay, Johanne Chambers, John C. Whitfield, John B. Gaziano, John M. Marten, Jonathan Coresh, Josef Jonas, Jost B. Mychaleckyj, Josyf C. Christensen, Kaare Eckardt, Kai-Uwe Mohlke, Karen L. Endlich, Karlhans Dittrich, Katalin Ryan, Kathleen A. Rice, Kenneth M. Taylor, Kent D. Ho, Kevin Nikus, Kjell Matsuda, Koichi Strauch, Konstantin Miliku, Kozeta Hveem, Kristian Lind, Lars Wallentin, Lars Yerges-Armstrong, Laura M. Raffield, Laura M. Phillips, Lawrence S. Launer, Lenore J. Lyytikäinen, Leo-Pekka Lange, Leslie A. Citterio, Lorena Klaric, Lucija Ikram, M. Arfan Ising, Marcus Kleber, Marcus E. Francescatto, Margherita Concas, Maria Pina Ciullo, Marina Piratsu, Mario Orho-Melander, Marju Laakso, Markku Loeffler, Markus Perola, Markus de Borst, Martin H. Gögele, Martin Bianca, Martina La Lukas, Mary Ann Feitosa, Mary F. Biggs, Mary L. Wojczynski, Mary K. Kavousi, Maryam Kanai, Masahiro Akiyama, Masato Yasuda, Masayuki Nauck, Matthias Waldenberger, Melanie Chee, Miao-Li Chee, Miao-Ling Boehnke, Michael Preuss, Michael H. Stumvoll, Michael Province, Michael A. Evans, Michele K. O’Donoghue, Michelle L. Kubo, Michiaki Kähönen, Mika Kastarinen, Mika Nalls, Mike A. Kuokkanen, Mikko Ghanbari, Mohsen Bochud, Murielle Josyula, Navya Shilpa Martin, Nicholas G. Tan, Nicholas Y. Q. Palmer, Nicholette D. Pirastu, Nicola Schupf, Nicole Verweij, Niek Hutri-Kähönen, Nina Mononen, Nina Bansal, Nisha Devuyst, Olivier Melander, Olle Raitakari, Olli T. Polasek, Ozren Manunta, Paolo Gasparini, Paolo Mishra, Pashupati P. Sulem, Patrick Magnusson, Patrik K. E. Elliott, Paul Ridker, Paul M. Hamet, Pavel Svensson, Per O. Joshi, Peter K. Kovacs, Peter Pramstaller, Peter P. Rossing, Peter Vollenweider, Peter van der Harst, Pim Dorajoo, Rajkumar Sim, Ralene Z. H. Burkhardt, Ralph Tao, Ran Noordam, Raymond Mägi, Reedik Schmidt, Reinhold de Mutsert, Renée Rueedi, Rico van Dam, Rob M. Carroll, Robert J. Gansevoort, Ron T. Loos, Ruth J. F. Felicita, Sala Cinzia Sedaghat, Sanaz Padmanabhan, Sandosh Freitag-Wolf, Sandra Pendergrass, Sarah A. Graham, Sarah E. Gordon, Scott D. Hwang, Shih-Jen Kerr, Shona M. Vaccargiu, Simona Patil, Snehal B. Hallan, Stein Bakker, Stephan J. L. Lim, Su-Chi Lucae, Susanne Vogelezang, Suzanne Bergmann, Sven Corre, Tanguy Ahluwalia, Tarunveer S. Lehtimäki, Terho Boutin, Thibaud S. Meitinger, Thomas Wong, Tien-Yin Bergler, Tobias Rabelink, Ton J. Esko, Tõnu Haller, Toomas Thorsteinsdottir, Unnur Völker, Uwe Foo, Valencia Hui Xian Salomaa, Veikko Vitart, Veronique Giedraitis, Vilmantas Gudnason, Vilmundur Jaddoe, Vincent W. V. Huang, Wei Zhang, Weihua Wei, Wen Bin Kiess, Wieland März, Winfried Koenig, Wolfgang Lieb, Wolfgang Gao, Xin Sim, Xueling Wang, Ya Xing Friedlander, Yechiel Tham, Yih-Chung Kamatani, Yoichiro Okada, Yukinori Milaneschi, Yuri Yu, Zhi Stark, Klaus J. Stefansson, Kari Böger, Carsten A. Hung, Adriana M. Kronenberg, Florian Köttgen, Anna Pattaro, Cristian Heid, Iris M. Commun Biol Article Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM. Nature Publishing Group UK 2022-06-13 /pmc/articles/PMC9192715/ /pubmed/35697829 http://dx.doi.org/10.1038/s42003-022-03448-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Winkler, Thomas W.
Rasheed, Humaira
Teumer, Alexander
Gorski, Mathias
Rowan, Bryce X.
Stanzick, Kira J.
Thomas, Laurent F.
Tin, Adrienne
Hoppmann, Anselm
Chu, Audrey Y.
Tayo, Bamidele
Thio, Chris H. L.
Cusi, Daniele
Chai, Jin-Fang
Sieber, Karsten B.
Horn, Katrin
Li, Man
Scholz, Markus
Cocca, Massimiliano
Wuttke, Matthias
van der Most, Peter J.
Yang, Qiong
Ghasemi, Sahar
Nutile, Teresa
Li, Yong
Pontali, Giulia
Günther, Felix
Dehghan, Abbas
Correa, Adolfo
Parsa, Afshin
Feresin, Agnese
de Vries, Aiko P. J.
Zonderman, Alan B.
Smith, Albert V.
Oldehinkel, Albertine J.
De Grandi, Alessandro
Rosenkranz, Alexander R.
Franke, Andre
Teren, Andrej
Metspalu, Andres
Hicks, Andrew A.
Morris, Andrew P.
Tönjes, Anke
Morgan, Anna
Podgornaia, Anna I.
Peters, Annette
Körner, Antje
Mahajan, Anubha
Campbell, Archie
Freedman, Barry I.
Spedicati, Beatrice
Ponte, Belen
Schöttker, Ben
Brumpton, Ben
Banas, Bernhard
Krämer, Bernhard K.
Jung, Bettina
Åsvold, Bjørn Olav
Smith, Blair H.
Ning, Boting
Penninx, Brenda W. J. H.
Vanderwerff, Brett R.
Psaty, Bruce M.
Kammerer, Candace M.
Langefeld, Carl D.
Hayward, Caroline
Spracklen, Cassandra N.
Robinson-Cohen, Cassianne
Hartman, Catharina A.
Lindgren, Cecilia M.
Wang, Chaolong
Sabanayagam, Charumathi
Heng, Chew-Kiat
Lanzani, Chiara
Khor, Chiea-Chuen
Cheng, Ching-Yu
Fuchsberger, Christian
Gieger, Christian
Shaffer, Christian M.
Schulz, Christina-Alexandra
Willer, Cristen J.
Chasman, Daniel I.
Gudbjartsson, Daniel F.
Ruggiero, Daniela
Toniolo, Daniela
Czamara, Darina
Porteous, David J.
Waterworth, Dawn M.
Mascalzoni, Deborah
Mook-Kanamori, Dennis O.
Reilly, Dermot F.
Daw, E. Warwick
Hofer, Edith
Boerwinkle, Eric
Salvi, Erika
Bottinger, Erwin P.
Tai, E-Shyong
Catamo, Eulalia
Rizzi, Federica
Guo, Feng
Rivadeneira, Fernando
Guilianini, Franco
Sveinbjornsson, Gardar
Ehret, Georg
Waeber, Gerard
Biino, Ginevra
Girotto, Giorgia
Pistis, Giorgio
Nadkarni, Girish N.
Delgado, Graciela E.
Montgomery, Grant W.
Snieder, Harold
Campbell, Harry
White, Harvey D.
Gao, He
Stringham, Heather M.
Schmidt, Helena
Li, Hengtong
Brenner, Hermann
Holm, Hilma
Kirsten, Holgen
Kramer, Holly
Rudan, Igor
Nolte, Ilja M.
Tzoulaki, Ioanna
Olafsson, Isleifur
Martins, Jade
Cook, James P.
Wilson, James F.
Halbritter, Jan
Felix, Janine F.
Divers, Jasmin
Kooner, Jaspal S.
Lee, Jeannette Jen-Mai
O’Connell, Jeffrey
Rotter, Jerome I.
Liu, Jianjun
Xu, Jie
Thiery, Joachim
Ärnlöv, Johan
Kuusisto, Johanna
Jakobsdottir, Johanna
Tremblay, Johanne
Chambers, John C.
Whitfield, John B.
Gaziano, John M.
Marten, Jonathan
Coresh, Josef
Jonas, Jost B.
Mychaleckyj, Josyf C.
Christensen, Kaare
Eckardt, Kai-Uwe
Mohlke, Karen L.
Endlich, Karlhans
Dittrich, Katalin
Ryan, Kathleen A.
Rice, Kenneth M.
Taylor, Kent D.
Ho, Kevin
Nikus, Kjell
Matsuda, Koichi
Strauch, Konstantin
Miliku, Kozeta
Hveem, Kristian
Lind, Lars
Wallentin, Lars
Yerges-Armstrong, Laura M.
Raffield, Laura M.
Phillips, Lawrence S.
Launer, Lenore J.
Lyytikäinen, Leo-Pekka
Lange, Leslie A.
Citterio, Lorena
Klaric, Lucija
Ikram, M. Arfan
Ising, Marcus
Kleber, Marcus E.
Francescatto, Margherita
Concas, Maria Pina
Ciullo, Marina
Piratsu, Mario
Orho-Melander, Marju
Laakso, Markku
Loeffler, Markus
Perola, Markus
de Borst, Martin H.
Gögele, Martin
Bianca, Martina La
Lukas, Mary Ann
Feitosa, Mary F.
Biggs, Mary L.
Wojczynski, Mary K.
Kavousi, Maryam
Kanai, Masahiro
Akiyama, Masato
Yasuda, Masayuki
Nauck, Matthias
Waldenberger, Melanie
Chee, Miao-Li
Chee, Miao-Ling
Boehnke, Michael
Preuss, Michael H.
Stumvoll, Michael
Province, Michael A.
Evans, Michele K.
O’Donoghue, Michelle L.
Kubo, Michiaki
Kähönen, Mika
Kastarinen, Mika
Nalls, Mike A.
Kuokkanen, Mikko
Ghanbari, Mohsen
Bochud, Murielle
Josyula, Navya Shilpa
Martin, Nicholas G.
Tan, Nicholas Y. Q.
Palmer, Nicholette D.
Pirastu, Nicola
Schupf, Nicole
Verweij, Niek
Hutri-Kähönen, Nina
Mononen, Nina
Bansal, Nisha
Devuyst, Olivier
Melander, Olle
Raitakari, Olli T.
Polasek, Ozren
Manunta, Paolo
Gasparini, Paolo
Mishra, Pashupati P.
Sulem, Patrick
Magnusson, Patrik K. E.
Elliott, Paul
Ridker, Paul M.
Hamet, Pavel
Svensson, Per O.
Joshi, Peter K.
Kovacs, Peter
Pramstaller, Peter P.
Rossing, Peter
Vollenweider, Peter
van der Harst, Pim
Dorajoo, Rajkumar
Sim, Ralene Z. H.
Burkhardt, Ralph
Tao, Ran
Noordam, Raymond
Mägi, Reedik
Schmidt, Reinhold
de Mutsert, Renée
Rueedi, Rico
van Dam, Rob M.
Carroll, Robert J.
Gansevoort, Ron T.
Loos, Ruth J. F.
Felicita, Sala Cinzia
Sedaghat, Sanaz
Padmanabhan, Sandosh
Freitag-Wolf, Sandra
Pendergrass, Sarah A.
Graham, Sarah E.
Gordon, Scott D.
Hwang, Shih-Jen
Kerr, Shona M.
Vaccargiu, Simona
Patil, Snehal B.
Hallan, Stein
Bakker, Stephan J. L.
Lim, Su-Chi
Lucae, Susanne
Vogelezang, Suzanne
Bergmann, Sven
Corre, Tanguy
Ahluwalia, Tarunveer S.
Lehtimäki, Terho
Boutin, Thibaud S.
Meitinger, Thomas
Wong, Tien-Yin
Bergler, Tobias
Rabelink, Ton J.
Esko, Tõnu
Haller, Toomas
Thorsteinsdottir, Unnur
Völker, Uwe
Foo, Valencia Hui Xian
Salomaa, Veikko
Vitart, Veronique
Giedraitis, Vilmantas
Gudnason, Vilmundur
Jaddoe, Vincent W. V.
Huang, Wei
Zhang, Weihua
Wei, Wen Bin
Kiess, Wieland
März, Winfried
Koenig, Wolfgang
Lieb, Wolfgang
Gao, Xin
Sim, Xueling
Wang, Ya Xing
Friedlander, Yechiel
Tham, Yih-Chung
Kamatani, Yoichiro
Okada, Yukinori
Milaneschi, Yuri
Yu, Zhi
Stark, Klaus J.
Stefansson, Kari
Böger, Carsten A.
Hung, Adriana M.
Kronenberg, Florian
Köttgen, Anna
Pattaro, Cristian
Heid, Iris M.
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
title Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
title_full Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
title_fullStr Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
title_full_unstemmed Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
title_short Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
title_sort differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192715/
https://www.ncbi.nlm.nih.gov/pubmed/35697829
http://dx.doi.org/10.1038/s42003-022-03448-z
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AT biancamartinala differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT nallsmikea differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT tannicholasyq differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT mononennina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT devuystolivier differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT melanderolle differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT elliottpaul differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT ridkerpaulm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT hametpavel differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT joshipeterk differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT vanderharstpim differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT dorajoorajkumar differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT burkhardtralph differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT taoran differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT noordamraymond differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT magireedik differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT schmidtreinhold differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT demutsertrenee differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT rueedirico differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT vandamrobm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT carrollrobertj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT gansevoortront differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT loosruthjf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT felicitasalacinzia differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT sedaghatsanaz differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT padmanabhansandosh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT freitagwolfsandra differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT pendergrasssaraha differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT grahamsarahe differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT gordonscottd differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT hwangshihjen differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT kerrshonam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT vaccargiusimona differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT patilsnehalb differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT hallanstein differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT bakkerstephanjl differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT limsuchi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT lucaesusanne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT vogelezangsuzanne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT bergmannsven differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
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AT lehtimakiterho differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT boutinthibauds differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT meitingerthomas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT wongtienyin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT berglertobias differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT rabelinktonj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT eskotonu differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT hallertoomas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT thorsteinsdottirunnur differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT volkeruwe differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT foovalenciahuixian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT salomaaveikko differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT vitartveronique differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT giedraitisvilmantas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT gudnasonvilmundur differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT jaddoevincentwv differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT huangwei differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT zhangweihua differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT weiwenbin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT kiesswieland differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT marzwinfried differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT koenigwolfgang differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT liebwolfgang differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT gaoxin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT simxueling differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT wangyaxing differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT friedlanderyechiel differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT thamyihchung differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT kamataniyoichiro differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT okadayukinori differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT milaneschiyuri differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT yuzhi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT starkklausj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT stefanssonkari differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT bogercarstena differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT hungadrianam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT kronenbergflorian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT kottgenanna differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT pattarocristian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals
AT heidirism differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals