Cargando…
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for indivi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192715/ https://www.ncbi.nlm.nih.gov/pubmed/35697829 http://dx.doi.org/10.1038/s42003-022-03448-z |
_version_ | 1784726303639863296 |
---|---|
author | Winkler, Thomas W. Rasheed, Humaira Teumer, Alexander Gorski, Mathias Rowan, Bryce X. Stanzick, Kira J. Thomas, Laurent F. Tin, Adrienne Hoppmann, Anselm Chu, Audrey Y. Tayo, Bamidele Thio, Chris H. L. Cusi, Daniele Chai, Jin-Fang Sieber, Karsten B. Horn, Katrin Li, Man Scholz, Markus Cocca, Massimiliano Wuttke, Matthias van der Most, Peter J. Yang, Qiong Ghasemi, Sahar Nutile, Teresa Li, Yong Pontali, Giulia Günther, Felix Dehghan, Abbas Correa, Adolfo Parsa, Afshin Feresin, Agnese de Vries, Aiko P. J. Zonderman, Alan B. Smith, Albert V. Oldehinkel, Albertine J. De Grandi, Alessandro Rosenkranz, Alexander R. Franke, Andre Teren, Andrej Metspalu, Andres Hicks, Andrew A. Morris, Andrew P. Tönjes, Anke Morgan, Anna Podgornaia, Anna I. Peters, Annette Körner, Antje Mahajan, Anubha Campbell, Archie Freedman, Barry I. Spedicati, Beatrice Ponte, Belen Schöttker, Ben Brumpton, Ben Banas, Bernhard Krämer, Bernhard K. Jung, Bettina Åsvold, Bjørn Olav Smith, Blair H. Ning, Boting Penninx, Brenda W. J. H. Vanderwerff, Brett R. Psaty, Bruce M. Kammerer, Candace M. Langefeld, Carl D. Hayward, Caroline Spracklen, Cassandra N. Robinson-Cohen, Cassianne Hartman, Catharina A. Lindgren, Cecilia M. Wang, Chaolong Sabanayagam, Charumathi Heng, Chew-Kiat Lanzani, Chiara Khor, Chiea-Chuen Cheng, Ching-Yu Fuchsberger, Christian Gieger, Christian Shaffer, Christian M. Schulz, Christina-Alexandra Willer, Cristen J. Chasman, Daniel I. Gudbjartsson, Daniel F. Ruggiero, Daniela Toniolo, Daniela Czamara, Darina Porteous, David J. Waterworth, Dawn M. Mascalzoni, Deborah Mook-Kanamori, Dennis O. Reilly, Dermot F. Daw, E. Warwick Hofer, Edith Boerwinkle, Eric Salvi, Erika Bottinger, Erwin P. Tai, E-Shyong Catamo, Eulalia Rizzi, Federica Guo, Feng Rivadeneira, Fernando Guilianini, Franco Sveinbjornsson, Gardar Ehret, Georg Waeber, Gerard Biino, Ginevra Girotto, Giorgia Pistis, Giorgio Nadkarni, Girish N. Delgado, Graciela E. Montgomery, Grant W. Snieder, Harold Campbell, Harry White, Harvey D. Gao, He Stringham, Heather M. Schmidt, Helena Li, Hengtong Brenner, Hermann Holm, Hilma Kirsten, Holgen Kramer, Holly Rudan, Igor Nolte, Ilja M. Tzoulaki, Ioanna Olafsson, Isleifur Martins, Jade Cook, James P. Wilson, James F. Halbritter, Jan Felix, Janine F. Divers, Jasmin Kooner, Jaspal S. Lee, Jeannette Jen-Mai O’Connell, Jeffrey Rotter, Jerome I. Liu, Jianjun Xu, Jie Thiery, Joachim Ärnlöv, Johan Kuusisto, Johanna Jakobsdottir, Johanna Tremblay, Johanne Chambers, John C. Whitfield, John B. Gaziano, John M. Marten, Jonathan Coresh, Josef Jonas, Jost B. Mychaleckyj, Josyf C. Christensen, Kaare Eckardt, Kai-Uwe Mohlke, Karen L. Endlich, Karlhans Dittrich, Katalin Ryan, Kathleen A. Rice, Kenneth M. Taylor, Kent D. Ho, Kevin Nikus, Kjell Matsuda, Koichi Strauch, Konstantin Miliku, Kozeta Hveem, Kristian Lind, Lars Wallentin, Lars Yerges-Armstrong, Laura M. Raffield, Laura M. Phillips, Lawrence S. Launer, Lenore J. Lyytikäinen, Leo-Pekka Lange, Leslie A. Citterio, Lorena Klaric, Lucija Ikram, M. Arfan Ising, Marcus Kleber, Marcus E. Francescatto, Margherita Concas, Maria Pina Ciullo, Marina Piratsu, Mario Orho-Melander, Marju Laakso, Markku Loeffler, Markus Perola, Markus de Borst, Martin H. Gögele, Martin Bianca, Martina La Lukas, Mary Ann Feitosa, Mary F. Biggs, Mary L. Wojczynski, Mary K. Kavousi, Maryam Kanai, Masahiro Akiyama, Masato Yasuda, Masayuki Nauck, Matthias Waldenberger, Melanie Chee, Miao-Li Chee, Miao-Ling Boehnke, Michael Preuss, Michael H. Stumvoll, Michael Province, Michael A. Evans, Michele K. O’Donoghue, Michelle L. Kubo, Michiaki Kähönen, Mika Kastarinen, Mika Nalls, Mike A. Kuokkanen, Mikko Ghanbari, Mohsen Bochud, Murielle Josyula, Navya Shilpa Martin, Nicholas G. Tan, Nicholas Y. Q. Palmer, Nicholette D. Pirastu, Nicola Schupf, Nicole Verweij, Niek Hutri-Kähönen, Nina Mononen, Nina Bansal, Nisha Devuyst, Olivier Melander, Olle Raitakari, Olli T. Polasek, Ozren Manunta, Paolo Gasparini, Paolo Mishra, Pashupati P. Sulem, Patrick Magnusson, Patrik K. E. Elliott, Paul Ridker, Paul M. Hamet, Pavel Svensson, Per O. Joshi, Peter K. Kovacs, Peter Pramstaller, Peter P. Rossing, Peter Vollenweider, Peter van der Harst, Pim Dorajoo, Rajkumar Sim, Ralene Z. H. Burkhardt, Ralph Tao, Ran Noordam, Raymond Mägi, Reedik Schmidt, Reinhold de Mutsert, Renée Rueedi, Rico van Dam, Rob M. Carroll, Robert J. Gansevoort, Ron T. Loos, Ruth J. F. Felicita, Sala Cinzia Sedaghat, Sanaz Padmanabhan, Sandosh Freitag-Wolf, Sandra Pendergrass, Sarah A. Graham, Sarah E. Gordon, Scott D. Hwang, Shih-Jen Kerr, Shona M. Vaccargiu, Simona Patil, Snehal B. Hallan, Stein Bakker, Stephan J. L. Lim, Su-Chi Lucae, Susanne Vogelezang, Suzanne Bergmann, Sven Corre, Tanguy Ahluwalia, Tarunveer S. Lehtimäki, Terho Boutin, Thibaud S. Meitinger, Thomas Wong, Tien-Yin Bergler, Tobias Rabelink, Ton J. Esko, Tõnu Haller, Toomas Thorsteinsdottir, Unnur Völker, Uwe Foo, Valencia Hui Xian Salomaa, Veikko Vitart, Veronique Giedraitis, Vilmantas Gudnason, Vilmundur Jaddoe, Vincent W. V. Huang, Wei Zhang, Weihua Wei, Wen Bin Kiess, Wieland März, Winfried Koenig, Wolfgang Lieb, Wolfgang Gao, Xin Sim, Xueling Wang, Ya Xing Friedlander, Yechiel Tham, Yih-Chung Kamatani, Yoichiro Okada, Yukinori Milaneschi, Yuri Yu, Zhi Stark, Klaus J. Stefansson, Kari Böger, Carsten A. Hung, Adriana M. Kronenberg, Florian Köttgen, Anna Pattaro, Cristian Heid, Iris M. |
author_facet | Winkler, Thomas W. Rasheed, Humaira Teumer, Alexander Gorski, Mathias Rowan, Bryce X. Stanzick, Kira J. Thomas, Laurent F. Tin, Adrienne Hoppmann, Anselm Chu, Audrey Y. Tayo, Bamidele Thio, Chris H. L. Cusi, Daniele Chai, Jin-Fang Sieber, Karsten B. Horn, Katrin Li, Man Scholz, Markus Cocca, Massimiliano Wuttke, Matthias van der Most, Peter J. Yang, Qiong Ghasemi, Sahar Nutile, Teresa Li, Yong Pontali, Giulia Günther, Felix Dehghan, Abbas Correa, Adolfo Parsa, Afshin Feresin, Agnese de Vries, Aiko P. J. Zonderman, Alan B. Smith, Albert V. Oldehinkel, Albertine J. De Grandi, Alessandro Rosenkranz, Alexander R. Franke, Andre Teren, Andrej Metspalu, Andres Hicks, Andrew A. Morris, Andrew P. Tönjes, Anke Morgan, Anna Podgornaia, Anna I. Peters, Annette Körner, Antje Mahajan, Anubha Campbell, Archie Freedman, Barry I. Spedicati, Beatrice Ponte, Belen Schöttker, Ben Brumpton, Ben Banas, Bernhard Krämer, Bernhard K. Jung, Bettina Åsvold, Bjørn Olav Smith, Blair H. Ning, Boting Penninx, Brenda W. J. H. Vanderwerff, Brett R. Psaty, Bruce M. Kammerer, Candace M. Langefeld, Carl D. Hayward, Caroline Spracklen, Cassandra N. Robinson-Cohen, Cassianne Hartman, Catharina A. Lindgren, Cecilia M. Wang, Chaolong Sabanayagam, Charumathi Heng, Chew-Kiat Lanzani, Chiara Khor, Chiea-Chuen Cheng, Ching-Yu Fuchsberger, Christian Gieger, Christian Shaffer, Christian M. Schulz, Christina-Alexandra Willer, Cristen J. Chasman, Daniel I. Gudbjartsson, Daniel F. Ruggiero, Daniela Toniolo, Daniela Czamara, Darina Porteous, David J. Waterworth, Dawn M. Mascalzoni, Deborah Mook-Kanamori, Dennis O. Reilly, Dermot F. Daw, E. Warwick Hofer, Edith Boerwinkle, Eric Salvi, Erika Bottinger, Erwin P. Tai, E-Shyong Catamo, Eulalia Rizzi, Federica Guo, Feng Rivadeneira, Fernando Guilianini, Franco Sveinbjornsson, Gardar Ehret, Georg Waeber, Gerard Biino, Ginevra Girotto, Giorgia Pistis, Giorgio Nadkarni, Girish N. Delgado, Graciela E. Montgomery, Grant W. Snieder, Harold Campbell, Harry White, Harvey D. Gao, He Stringham, Heather M. Schmidt, Helena Li, Hengtong Brenner, Hermann Holm, Hilma Kirsten, Holgen Kramer, Holly Rudan, Igor Nolte, Ilja M. Tzoulaki, Ioanna Olafsson, Isleifur Martins, Jade Cook, James P. Wilson, James F. Halbritter, Jan Felix, Janine F. Divers, Jasmin Kooner, Jaspal S. Lee, Jeannette Jen-Mai O’Connell, Jeffrey Rotter, Jerome I. Liu, Jianjun Xu, Jie Thiery, Joachim Ärnlöv, Johan Kuusisto, Johanna Jakobsdottir, Johanna Tremblay, Johanne Chambers, John C. Whitfield, John B. Gaziano, John M. Marten, Jonathan Coresh, Josef Jonas, Jost B. Mychaleckyj, Josyf C. Christensen, Kaare Eckardt, Kai-Uwe Mohlke, Karen L. Endlich, Karlhans Dittrich, Katalin Ryan, Kathleen A. Rice, Kenneth M. Taylor, Kent D. Ho, Kevin Nikus, Kjell Matsuda, Koichi Strauch, Konstantin Miliku, Kozeta Hveem, Kristian Lind, Lars Wallentin, Lars Yerges-Armstrong, Laura M. Raffield, Laura M. Phillips, Lawrence S. Launer, Lenore J. Lyytikäinen, Leo-Pekka Lange, Leslie A. Citterio, Lorena Klaric, Lucija Ikram, M. Arfan Ising, Marcus Kleber, Marcus E. Francescatto, Margherita Concas, Maria Pina Ciullo, Marina Piratsu, Mario Orho-Melander, Marju Laakso, Markku Loeffler, Markus Perola, Markus de Borst, Martin H. Gögele, Martin Bianca, Martina La Lukas, Mary Ann Feitosa, Mary F. Biggs, Mary L. Wojczynski, Mary K. Kavousi, Maryam Kanai, Masahiro Akiyama, Masato Yasuda, Masayuki Nauck, Matthias Waldenberger, Melanie Chee, Miao-Li Chee, Miao-Ling Boehnke, Michael Preuss, Michael H. Stumvoll, Michael Province, Michael A. Evans, Michele K. O’Donoghue, Michelle L. Kubo, Michiaki Kähönen, Mika Kastarinen, Mika Nalls, Mike A. Kuokkanen, Mikko Ghanbari, Mohsen Bochud, Murielle Josyula, Navya Shilpa Martin, Nicholas G. Tan, Nicholas Y. Q. Palmer, Nicholette D. Pirastu, Nicola Schupf, Nicole Verweij, Niek Hutri-Kähönen, Nina Mononen, Nina Bansal, Nisha Devuyst, Olivier Melander, Olle Raitakari, Olli T. Polasek, Ozren Manunta, Paolo Gasparini, Paolo Mishra, Pashupati P. Sulem, Patrick Magnusson, Patrik K. E. Elliott, Paul Ridker, Paul M. Hamet, Pavel Svensson, Per O. Joshi, Peter K. Kovacs, Peter Pramstaller, Peter P. Rossing, Peter Vollenweider, Peter van der Harst, Pim Dorajoo, Rajkumar Sim, Ralene Z. H. Burkhardt, Ralph Tao, Ran Noordam, Raymond Mägi, Reedik Schmidt, Reinhold de Mutsert, Renée Rueedi, Rico van Dam, Rob M. Carroll, Robert J. Gansevoort, Ron T. Loos, Ruth J. F. Felicita, Sala Cinzia Sedaghat, Sanaz Padmanabhan, Sandosh Freitag-Wolf, Sandra Pendergrass, Sarah A. Graham, Sarah E. Gordon, Scott D. Hwang, Shih-Jen Kerr, Shona M. Vaccargiu, Simona Patil, Snehal B. Hallan, Stein Bakker, Stephan J. L. Lim, Su-Chi Lucae, Susanne Vogelezang, Suzanne Bergmann, Sven Corre, Tanguy Ahluwalia, Tarunveer S. Lehtimäki, Terho Boutin, Thibaud S. Meitinger, Thomas Wong, Tien-Yin Bergler, Tobias Rabelink, Ton J. Esko, Tõnu Haller, Toomas Thorsteinsdottir, Unnur Völker, Uwe Foo, Valencia Hui Xian Salomaa, Veikko Vitart, Veronique Giedraitis, Vilmantas Gudnason, Vilmundur Jaddoe, Vincent W. V. Huang, Wei Zhang, Weihua Wei, Wen Bin Kiess, Wieland März, Winfried Koenig, Wolfgang Lieb, Wolfgang Gao, Xin Sim, Xueling Wang, Ya Xing Friedlander, Yechiel Tham, Yih-Chung Kamatani, Yoichiro Okada, Yukinori Milaneschi, Yuri Yu, Zhi Stark, Klaus J. Stefansson, Kari Böger, Carsten A. Hung, Adriana M. Kronenberg, Florian Köttgen, Anna Pattaro, Cristian Heid, Iris M. |
author_sort | Winkler, Thomas W. |
collection | PubMed |
description | Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM. |
format | Online Article Text |
id | pubmed-9192715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91927152022-06-15 Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals Winkler, Thomas W. Rasheed, Humaira Teumer, Alexander Gorski, Mathias Rowan, Bryce X. Stanzick, Kira J. Thomas, Laurent F. Tin, Adrienne Hoppmann, Anselm Chu, Audrey Y. Tayo, Bamidele Thio, Chris H. L. Cusi, Daniele Chai, Jin-Fang Sieber, Karsten B. Horn, Katrin Li, Man Scholz, Markus Cocca, Massimiliano Wuttke, Matthias van der Most, Peter J. Yang, Qiong Ghasemi, Sahar Nutile, Teresa Li, Yong Pontali, Giulia Günther, Felix Dehghan, Abbas Correa, Adolfo Parsa, Afshin Feresin, Agnese de Vries, Aiko P. J. Zonderman, Alan B. Smith, Albert V. Oldehinkel, Albertine J. De Grandi, Alessandro Rosenkranz, Alexander R. Franke, Andre Teren, Andrej Metspalu, Andres Hicks, Andrew A. Morris, Andrew P. Tönjes, Anke Morgan, Anna Podgornaia, Anna I. Peters, Annette Körner, Antje Mahajan, Anubha Campbell, Archie Freedman, Barry I. Spedicati, Beatrice Ponte, Belen Schöttker, Ben Brumpton, Ben Banas, Bernhard Krämer, Bernhard K. Jung, Bettina Åsvold, Bjørn Olav Smith, Blair H. Ning, Boting Penninx, Brenda W. J. H. Vanderwerff, Brett R. Psaty, Bruce M. Kammerer, Candace M. Langefeld, Carl D. Hayward, Caroline Spracklen, Cassandra N. Robinson-Cohen, Cassianne Hartman, Catharina A. Lindgren, Cecilia M. Wang, Chaolong Sabanayagam, Charumathi Heng, Chew-Kiat Lanzani, Chiara Khor, Chiea-Chuen Cheng, Ching-Yu Fuchsberger, Christian Gieger, Christian Shaffer, Christian M. Schulz, Christina-Alexandra Willer, Cristen J. Chasman, Daniel I. Gudbjartsson, Daniel F. Ruggiero, Daniela Toniolo, Daniela Czamara, Darina Porteous, David J. Waterworth, Dawn M. Mascalzoni, Deborah Mook-Kanamori, Dennis O. Reilly, Dermot F. Daw, E. Warwick Hofer, Edith Boerwinkle, Eric Salvi, Erika Bottinger, Erwin P. Tai, E-Shyong Catamo, Eulalia Rizzi, Federica Guo, Feng Rivadeneira, Fernando Guilianini, Franco Sveinbjornsson, Gardar Ehret, Georg Waeber, Gerard Biino, Ginevra Girotto, Giorgia Pistis, Giorgio Nadkarni, Girish N. Delgado, Graciela E. Montgomery, Grant W. Snieder, Harold Campbell, Harry White, Harvey D. Gao, He Stringham, Heather M. Schmidt, Helena Li, Hengtong Brenner, Hermann Holm, Hilma Kirsten, Holgen Kramer, Holly Rudan, Igor Nolte, Ilja M. Tzoulaki, Ioanna Olafsson, Isleifur Martins, Jade Cook, James P. Wilson, James F. Halbritter, Jan Felix, Janine F. Divers, Jasmin Kooner, Jaspal S. Lee, Jeannette Jen-Mai O’Connell, Jeffrey Rotter, Jerome I. Liu, Jianjun Xu, Jie Thiery, Joachim Ärnlöv, Johan Kuusisto, Johanna Jakobsdottir, Johanna Tremblay, Johanne Chambers, John C. Whitfield, John B. Gaziano, John M. Marten, Jonathan Coresh, Josef Jonas, Jost B. Mychaleckyj, Josyf C. Christensen, Kaare Eckardt, Kai-Uwe Mohlke, Karen L. Endlich, Karlhans Dittrich, Katalin Ryan, Kathleen A. Rice, Kenneth M. Taylor, Kent D. Ho, Kevin Nikus, Kjell Matsuda, Koichi Strauch, Konstantin Miliku, Kozeta Hveem, Kristian Lind, Lars Wallentin, Lars Yerges-Armstrong, Laura M. Raffield, Laura M. Phillips, Lawrence S. Launer, Lenore J. Lyytikäinen, Leo-Pekka Lange, Leslie A. Citterio, Lorena Klaric, Lucija Ikram, M. Arfan Ising, Marcus Kleber, Marcus E. Francescatto, Margherita Concas, Maria Pina Ciullo, Marina Piratsu, Mario Orho-Melander, Marju Laakso, Markku Loeffler, Markus Perola, Markus de Borst, Martin H. Gögele, Martin Bianca, Martina La Lukas, Mary Ann Feitosa, Mary F. Biggs, Mary L. Wojczynski, Mary K. Kavousi, Maryam Kanai, Masahiro Akiyama, Masato Yasuda, Masayuki Nauck, Matthias Waldenberger, Melanie Chee, Miao-Li Chee, Miao-Ling Boehnke, Michael Preuss, Michael H. Stumvoll, Michael Province, Michael A. Evans, Michele K. O’Donoghue, Michelle L. Kubo, Michiaki Kähönen, Mika Kastarinen, Mika Nalls, Mike A. Kuokkanen, Mikko Ghanbari, Mohsen Bochud, Murielle Josyula, Navya Shilpa Martin, Nicholas G. Tan, Nicholas Y. Q. Palmer, Nicholette D. Pirastu, Nicola Schupf, Nicole Verweij, Niek Hutri-Kähönen, Nina Mononen, Nina Bansal, Nisha Devuyst, Olivier Melander, Olle Raitakari, Olli T. Polasek, Ozren Manunta, Paolo Gasparini, Paolo Mishra, Pashupati P. Sulem, Patrick Magnusson, Patrik K. E. Elliott, Paul Ridker, Paul M. Hamet, Pavel Svensson, Per O. Joshi, Peter K. Kovacs, Peter Pramstaller, Peter P. Rossing, Peter Vollenweider, Peter van der Harst, Pim Dorajoo, Rajkumar Sim, Ralene Z. H. Burkhardt, Ralph Tao, Ran Noordam, Raymond Mägi, Reedik Schmidt, Reinhold de Mutsert, Renée Rueedi, Rico van Dam, Rob M. Carroll, Robert J. Gansevoort, Ron T. Loos, Ruth J. F. Felicita, Sala Cinzia Sedaghat, Sanaz Padmanabhan, Sandosh Freitag-Wolf, Sandra Pendergrass, Sarah A. Graham, Sarah E. Gordon, Scott D. Hwang, Shih-Jen Kerr, Shona M. Vaccargiu, Simona Patil, Snehal B. Hallan, Stein Bakker, Stephan J. L. Lim, Su-Chi Lucae, Susanne Vogelezang, Suzanne Bergmann, Sven Corre, Tanguy Ahluwalia, Tarunveer S. Lehtimäki, Terho Boutin, Thibaud S. Meitinger, Thomas Wong, Tien-Yin Bergler, Tobias Rabelink, Ton J. Esko, Tõnu Haller, Toomas Thorsteinsdottir, Unnur Völker, Uwe Foo, Valencia Hui Xian Salomaa, Veikko Vitart, Veronique Giedraitis, Vilmantas Gudnason, Vilmundur Jaddoe, Vincent W. V. Huang, Wei Zhang, Weihua Wei, Wen Bin Kiess, Wieland März, Winfried Koenig, Wolfgang Lieb, Wolfgang Gao, Xin Sim, Xueling Wang, Ya Xing Friedlander, Yechiel Tham, Yih-Chung Kamatani, Yoichiro Okada, Yukinori Milaneschi, Yuri Yu, Zhi Stark, Klaus J. Stefansson, Kari Böger, Carsten A. Hung, Adriana M. Kronenberg, Florian Köttgen, Anna Pattaro, Cristian Heid, Iris M. Commun Biol Article Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM. Nature Publishing Group UK 2022-06-13 /pmc/articles/PMC9192715/ /pubmed/35697829 http://dx.doi.org/10.1038/s42003-022-03448-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Winkler, Thomas W. Rasheed, Humaira Teumer, Alexander Gorski, Mathias Rowan, Bryce X. Stanzick, Kira J. Thomas, Laurent F. Tin, Adrienne Hoppmann, Anselm Chu, Audrey Y. Tayo, Bamidele Thio, Chris H. L. Cusi, Daniele Chai, Jin-Fang Sieber, Karsten B. Horn, Katrin Li, Man Scholz, Markus Cocca, Massimiliano Wuttke, Matthias van der Most, Peter J. Yang, Qiong Ghasemi, Sahar Nutile, Teresa Li, Yong Pontali, Giulia Günther, Felix Dehghan, Abbas Correa, Adolfo Parsa, Afshin Feresin, Agnese de Vries, Aiko P. J. Zonderman, Alan B. Smith, Albert V. Oldehinkel, Albertine J. De Grandi, Alessandro Rosenkranz, Alexander R. Franke, Andre Teren, Andrej Metspalu, Andres Hicks, Andrew A. Morris, Andrew P. Tönjes, Anke Morgan, Anna Podgornaia, Anna I. Peters, Annette Körner, Antje Mahajan, Anubha Campbell, Archie Freedman, Barry I. Spedicati, Beatrice Ponte, Belen Schöttker, Ben Brumpton, Ben Banas, Bernhard Krämer, Bernhard K. Jung, Bettina Åsvold, Bjørn Olav Smith, Blair H. Ning, Boting Penninx, Brenda W. J. H. Vanderwerff, Brett R. Psaty, Bruce M. Kammerer, Candace M. Langefeld, Carl D. Hayward, Caroline Spracklen, Cassandra N. Robinson-Cohen, Cassianne Hartman, Catharina A. Lindgren, Cecilia M. Wang, Chaolong Sabanayagam, Charumathi Heng, Chew-Kiat Lanzani, Chiara Khor, Chiea-Chuen Cheng, Ching-Yu Fuchsberger, Christian Gieger, Christian Shaffer, Christian M. Schulz, Christina-Alexandra Willer, Cristen J. Chasman, Daniel I. Gudbjartsson, Daniel F. Ruggiero, Daniela Toniolo, Daniela Czamara, Darina Porteous, David J. Waterworth, Dawn M. Mascalzoni, Deborah Mook-Kanamori, Dennis O. Reilly, Dermot F. Daw, E. Warwick Hofer, Edith Boerwinkle, Eric Salvi, Erika Bottinger, Erwin P. Tai, E-Shyong Catamo, Eulalia Rizzi, Federica Guo, Feng Rivadeneira, Fernando Guilianini, Franco Sveinbjornsson, Gardar Ehret, Georg Waeber, Gerard Biino, Ginevra Girotto, Giorgia Pistis, Giorgio Nadkarni, Girish N. Delgado, Graciela E. Montgomery, Grant W. Snieder, Harold Campbell, Harry White, Harvey D. Gao, He Stringham, Heather M. Schmidt, Helena Li, Hengtong Brenner, Hermann Holm, Hilma Kirsten, Holgen Kramer, Holly Rudan, Igor Nolte, Ilja M. Tzoulaki, Ioanna Olafsson, Isleifur Martins, Jade Cook, James P. Wilson, James F. Halbritter, Jan Felix, Janine F. Divers, Jasmin Kooner, Jaspal S. Lee, Jeannette Jen-Mai O’Connell, Jeffrey Rotter, Jerome I. Liu, Jianjun Xu, Jie Thiery, Joachim Ärnlöv, Johan Kuusisto, Johanna Jakobsdottir, Johanna Tremblay, Johanne Chambers, John C. Whitfield, John B. Gaziano, John M. Marten, Jonathan Coresh, Josef Jonas, Jost B. Mychaleckyj, Josyf C. Christensen, Kaare Eckardt, Kai-Uwe Mohlke, Karen L. Endlich, Karlhans Dittrich, Katalin Ryan, Kathleen A. Rice, Kenneth M. Taylor, Kent D. Ho, Kevin Nikus, Kjell Matsuda, Koichi Strauch, Konstantin Miliku, Kozeta Hveem, Kristian Lind, Lars Wallentin, Lars Yerges-Armstrong, Laura M. Raffield, Laura M. Phillips, Lawrence S. Launer, Lenore J. Lyytikäinen, Leo-Pekka Lange, Leslie A. Citterio, Lorena Klaric, Lucija Ikram, M. Arfan Ising, Marcus Kleber, Marcus E. Francescatto, Margherita Concas, Maria Pina Ciullo, Marina Piratsu, Mario Orho-Melander, Marju Laakso, Markku Loeffler, Markus Perola, Markus de Borst, Martin H. Gögele, Martin Bianca, Martina La Lukas, Mary Ann Feitosa, Mary F. Biggs, Mary L. Wojczynski, Mary K. Kavousi, Maryam Kanai, Masahiro Akiyama, Masato Yasuda, Masayuki Nauck, Matthias Waldenberger, Melanie Chee, Miao-Li Chee, Miao-Ling Boehnke, Michael Preuss, Michael H. Stumvoll, Michael Province, Michael A. Evans, Michele K. O’Donoghue, Michelle L. Kubo, Michiaki Kähönen, Mika Kastarinen, Mika Nalls, Mike A. Kuokkanen, Mikko Ghanbari, Mohsen Bochud, Murielle Josyula, Navya Shilpa Martin, Nicholas G. Tan, Nicholas Y. Q. Palmer, Nicholette D. Pirastu, Nicola Schupf, Nicole Verweij, Niek Hutri-Kähönen, Nina Mononen, Nina Bansal, Nisha Devuyst, Olivier Melander, Olle Raitakari, Olli T. Polasek, Ozren Manunta, Paolo Gasparini, Paolo Mishra, Pashupati P. Sulem, Patrick Magnusson, Patrik K. E. Elliott, Paul Ridker, Paul M. Hamet, Pavel Svensson, Per O. Joshi, Peter K. Kovacs, Peter Pramstaller, Peter P. Rossing, Peter Vollenweider, Peter van der Harst, Pim Dorajoo, Rajkumar Sim, Ralene Z. H. Burkhardt, Ralph Tao, Ran Noordam, Raymond Mägi, Reedik Schmidt, Reinhold de Mutsert, Renée Rueedi, Rico van Dam, Rob M. Carroll, Robert J. Gansevoort, Ron T. Loos, Ruth J. F. Felicita, Sala Cinzia Sedaghat, Sanaz Padmanabhan, Sandosh Freitag-Wolf, Sandra Pendergrass, Sarah A. Graham, Sarah E. Gordon, Scott D. Hwang, Shih-Jen Kerr, Shona M. Vaccargiu, Simona Patil, Snehal B. Hallan, Stein Bakker, Stephan J. L. Lim, Su-Chi Lucae, Susanne Vogelezang, Suzanne Bergmann, Sven Corre, Tanguy Ahluwalia, Tarunveer S. Lehtimäki, Terho Boutin, Thibaud S. Meitinger, Thomas Wong, Tien-Yin Bergler, Tobias Rabelink, Ton J. Esko, Tõnu Haller, Toomas Thorsteinsdottir, Unnur Völker, Uwe Foo, Valencia Hui Xian Salomaa, Veikko Vitart, Veronique Giedraitis, Vilmantas Gudnason, Vilmundur Jaddoe, Vincent W. V. Huang, Wei Zhang, Weihua Wei, Wen Bin Kiess, Wieland März, Winfried Koenig, Wolfgang Lieb, Wolfgang Gao, Xin Sim, Xueling Wang, Ya Xing Friedlander, Yechiel Tham, Yih-Chung Kamatani, Yoichiro Okada, Yukinori Milaneschi, Yuri Yu, Zhi Stark, Klaus J. Stefansson, Kari Böger, Carsten A. Hung, Adriana M. Kronenberg, Florian Köttgen, Anna Pattaro, Cristian Heid, Iris M. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
title | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
title_full | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
title_fullStr | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
title_full_unstemmed | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
title_short | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
title_sort | differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192715/ https://www.ncbi.nlm.nih.gov/pubmed/35697829 http://dx.doi.org/10.1038/s42003-022-03448-z |
work_keys_str_mv | AT winklerthomasw differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rasheedhumaira differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT teumeralexander differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gorskimathias differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rowanbrycex differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT stanzickkiraj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT thomaslaurentf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT tinadrienne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hoppmannanselm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT chuaudreyy differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT tayobamidele differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT thiochrishl differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT cusidaniele differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT chaijinfang differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT sieberkarstenb differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hornkatrin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT liman differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT scholzmarkus differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT coccamassimiliano differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wuttkematthias differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vandermostpeterj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT yangqiong differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ghasemisahar differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT nutileteresa differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT liyong differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pontaligiulia differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT guntherfelix differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT dehghanabbas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT correaadolfo differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT parsaafshin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT feresinagnese differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT devriesaikopj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT zondermanalanb differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT smithalbertv differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT oldehinkelalbertinej differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT degrandialessandro differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rosenkranzalexanderr differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT frankeandre differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT terenandrej differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT metspaluandres differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hicksandrewa differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT morrisandrewp differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT tonjesanke differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT morgananna differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT podgornaiaannai differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT petersannette differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kornerantje differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mahajananubha differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT campbellarchie differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT freedmanbarryi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT spedicatibeatrice differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pontebelen differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT schottkerben differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT brumptonben differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT banasbernhard differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kramerbernhardk differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT jungbettina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT asvoldbjørnolav differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT smithblairh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ningboting differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT penninxbrendawjh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vanderwerffbrettr differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT psatybrucem differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kammerercandacem differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT langefeldcarld differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT haywardcaroline differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT spracklencassandran differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT robinsoncohencassianne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hartmancatharinaa differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lindgrenceciliam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wangchaolong differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT sabanayagamcharumathi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hengchewkiat differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lanzanichiara differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT khorchieachuen differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT chengchingyu differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT fuchsbergerchristian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT giegerchristian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT shafferchristianm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT schulzchristinaalexandra differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT willercristenj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT chasmandanieli differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gudbjartssondanielf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ruggierodaniela differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT toniolodaniela differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT czamaradarina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT porteousdavidj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT waterworthdawnm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mascalzonideborah differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mookkanamoridenniso differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT reillydermotf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT dawewarwick differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hoferedith differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT boerwinkleeric differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT salvierika differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT bottingererwinp differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT taieshyong differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT catamoeulalia differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rizzifederica differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT guofeng differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rivadeneirafernando differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT guilianinifranco differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT sveinbjornssongardar differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ehretgeorg differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT waebergerard differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT biinoginevra differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT girottogiorgia differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pistisgiorgio differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT nadkarnigirishn differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT delgadogracielae differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT montgomerygrantw differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT sniederharold differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT campbellharry differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT whiteharveyd differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gaohe differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT stringhamheatherm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT schmidthelena differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lihengtong differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT brennerhermann differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT holmhilma differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kirstenholgen differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kramerholly differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rudanigor differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT nolteiljam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT tzoulakiioanna differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT olafssonisleifur differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT martinsjade differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT cookjamesp differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wilsonjamesf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT halbritterjan differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT felixjaninef differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT diversjasmin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT koonerjaspals differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT leejeannettejenmai differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT oconnelljeffrey differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rotterjeromei differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT liujianjun differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT xujie differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT thieryjoachim differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT arnlovjohan differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kuusistojohanna differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT jakobsdottirjohanna differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT tremblayjohanne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT chambersjohnc differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT whitfieldjohnb differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gazianojohnm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT martenjonathan differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT coreshjosef differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT jonasjostb differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mychaleckyjjosyfc differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT christensenkaare differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT eckardtkaiuwe differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mohlkekarenl differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT endlichkarlhans differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT dittrichkatalin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ryankathleena differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ricekennethm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT taylorkentd differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hokevin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT nikuskjell differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT matsudakoichi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT strauchkonstantin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT milikukozeta differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hveemkristian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lindlars differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wallentinlars differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT yergesarmstronglauram differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT raffieldlauram differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT phillipslawrences differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT launerlenorej differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lyytikainenleopekka differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT langelesliea differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT citteriolorena differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT klariclucija differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ikrammarfan differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT isingmarcus differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT klebermarcuse differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT francescattomargherita differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT concasmariapina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ciullomarina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT piratsumario differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT orhomelandermarju differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT laaksomarkku differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT loefflermarkus differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT perolamarkus differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT deborstmartinh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gogelemartin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT biancamartinala differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lukasmaryann differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT feitosamaryf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT biggsmaryl differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wojczynskimaryk differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kavousimaryam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kanaimasahiro differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT akiyamamasato differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT yasudamasayuki differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT nauckmatthias differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT waldenbergermelanie differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT cheemiaoli differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT cheemiaoling differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT boehnkemichael differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT preussmichaelh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT stumvollmichael differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT provincemichaela differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT evansmichelek differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT odonoghuemichellel differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kubomichiaki differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kahonenmika differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kastarinenmika differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT nallsmikea differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kuokkanenmikko differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ghanbarimohsen differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT bochudmurielle differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT josyulanavyashilpa differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT martinnicholasg differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT tannicholasyq differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT palmernicholetted differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pirastunicola differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT schupfnicole differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT verweijniek differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hutrikahonennina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mononennina differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT bansalnisha differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT devuystolivier differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT melanderolle differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT raitakariollit differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT polasekozren differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT manuntapaolo differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gasparinipaolo differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT mishrapashupatip differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT sulempatrick differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT magnussonpatrikke differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT elliottpaul differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ridkerpaulm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hametpavel differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT svenssonpero differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT joshipeterk differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kovacspeter differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pramstallerpeterp differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rossingpeter differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vollenweiderpeter differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vanderharstpim differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT dorajoorajkumar differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT simralenezh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT burkhardtralph differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT taoran differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT noordamraymond differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT magireedik differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT schmidtreinhold differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT demutsertrenee differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rueedirico differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vandamrobm differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT carrollrobertj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gansevoortront differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT loosruthjf differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT felicitasalacinzia differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT sedaghatsanaz differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT padmanabhansandosh differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT freitagwolfsandra differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pendergrasssaraha differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT grahamsarahe differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gordonscottd differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hwangshihjen differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kerrshonam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vaccargiusimona differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT patilsnehalb differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hallanstein differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT bakkerstephanjl differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT limsuchi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lucaesusanne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vogelezangsuzanne differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT bergmannsven differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT corretanguy differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT ahluwaliatarunveers differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT lehtimakiterho differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT boutinthibauds differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT meitingerthomas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wongtienyin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT berglertobias differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT rabelinktonj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT eskotonu differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hallertoomas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT thorsteinsdottirunnur differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT volkeruwe differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT foovalenciahuixian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT salomaaveikko differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT vitartveronique differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT giedraitisvilmantas differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gudnasonvilmundur differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT jaddoevincentwv differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT huangwei differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT zhangweihua differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT weiwenbin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kiesswieland differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT marzwinfried differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT koenigwolfgang differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT liebwolfgang differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT gaoxin differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT simxueling differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT wangyaxing differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT friedlanderyechiel differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT thamyihchung differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kamataniyoichiro differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT okadayukinori differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT milaneschiyuri differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT yuzhi differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT starkklausj differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT stefanssonkari differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT bogercarstena differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT hungadrianam differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kronenbergflorian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT kottgenanna differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT pattarocristian differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals AT heidirism differentialandsharedgeneticeffectsonkidneyfunctionbetweendiabeticandnondiabeticindividuals |