ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids

Epidermal omega-O-acylceramides (ω-O-acylCers) are essential components of a competent skin barrier. These unusual sphingolipids with ultralong N-acyl chains contain linoleic acid esterified to the terminal hydroxyl of the N-acyl, the formation of which requires the transacylase activity of patatin-...

Descripción completa

Detalles Bibliográficos
Autores principales: Opálka, Lukáš, Meyer, Jason M., Ondrejčeková, Veronika, Svatošová, Linda, Radner, Franz P.W., Vávrová, Kateřina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192818/
https://www.ncbi.nlm.nih.gov/pubmed/35568253
http://dx.doi.org/10.1016/j.jlr.2022.100226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192818/
https://www.ncbi.nlm.nih.gov/pubmed/35568253
http://dx.doi.org/10.1016/j.jlr.2022.100226

Ejemplares similares