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NEMA characterization of the SAFIR prototype PET insert

BACKGROUND: The SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner. The insert is designed to perform with an excellent coincidence resolving time of 194 ps Full...

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Autores principales: Khateri, Parisa, Lustermann, Werner, Ritzer, Christian, Tsoumpas, Charalampos, Dissertori, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192892/
https://www.ncbi.nlm.nih.gov/pubmed/35695989
http://dx.doi.org/10.1186/s40658-022-00454-2
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author Khateri, Parisa
Lustermann, Werner
Ritzer, Christian
Tsoumpas, Charalampos
Dissertori, Günther
author_facet Khateri, Parisa
Lustermann, Werner
Ritzer, Christian
Tsoumpas, Charalampos
Dissertori, Günther
author_sort Khateri, Parisa
collection PubMed
description BACKGROUND: The SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner. The insert is designed to perform with an excellent coincidence resolving time of 194 ps Full Width Half Maximum (FWHM) and an energy resolution of 13.8% FWHM. These properties enable it to acquire precise quantitative images at activities as high as 500 MBq suitable for studying fast biological processes within short time frames (< 5 s). In this study, the performance of the SAFIR prototype insert is evaluated according to the NEMA NU 4-2008 standard while the insert is inside the MRI without acquiring MRI data. RESULTS: Applying an energy window of 391–601 keV and a coincidence time window of 500 ps the following results are achieved. The average spatial resolution at 5 mm radial offset is 2.6 mm FWHM when using the Filtered Backprojection 3D Reprojection (FBP3DRP) reconstruction method, improving to 1.2 mm when using the Maximum Likelihood Expectation Maximization (MLEM) method. The peak sensitivity at the center of the scanner is 1.06%. The Noise Equivalent count Rate (NECR) is 799 kcps at the highest measured activity of 537 MBq for the mouse phantom and 121 kcps at the highest measured activity of 624 MBq for the rat phantom. The NECR peak is not yet reached for any of the measurements. The scatter fractions are 10.9% and 17.8% for the mouse and rat phantoms, respectively. The uniform region of the image quality phantom has a 3.0% STD, with a 4.6% deviation from the expected number of counts per voxel. The spill-over ratios for the water and air chambers are 0.18 and 0.17, respectively. CONCLUSIONS: The results satisfy all the requirements initially considered for the insert, proving that the SAFIR prototype insert can obtain dynamic images of small rodents at high activities ([Formula: see text] 500 MBq) with a high sensitivity and an excellent count-rate performance.
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spelling pubmed-91928922022-06-15 NEMA characterization of the SAFIR prototype PET insert Khateri, Parisa Lustermann, Werner Ritzer, Christian Tsoumpas, Charalampos Dissertori, Günther EJNMMI Phys Original Research BACKGROUND: The SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner. The insert is designed to perform with an excellent coincidence resolving time of 194 ps Full Width Half Maximum (FWHM) and an energy resolution of 13.8% FWHM. These properties enable it to acquire precise quantitative images at activities as high as 500 MBq suitable for studying fast biological processes within short time frames (< 5 s). In this study, the performance of the SAFIR prototype insert is evaluated according to the NEMA NU 4-2008 standard while the insert is inside the MRI without acquiring MRI data. RESULTS: Applying an energy window of 391–601 keV and a coincidence time window of 500 ps the following results are achieved. The average spatial resolution at 5 mm radial offset is 2.6 mm FWHM when using the Filtered Backprojection 3D Reprojection (FBP3DRP) reconstruction method, improving to 1.2 mm when using the Maximum Likelihood Expectation Maximization (MLEM) method. The peak sensitivity at the center of the scanner is 1.06%. The Noise Equivalent count Rate (NECR) is 799 kcps at the highest measured activity of 537 MBq for the mouse phantom and 121 kcps at the highest measured activity of 624 MBq for the rat phantom. The NECR peak is not yet reached for any of the measurements. The scatter fractions are 10.9% and 17.8% for the mouse and rat phantoms, respectively. The uniform region of the image quality phantom has a 3.0% STD, with a 4.6% deviation from the expected number of counts per voxel. The spill-over ratios for the water and air chambers are 0.18 and 0.17, respectively. CONCLUSIONS: The results satisfy all the requirements initially considered for the insert, proving that the SAFIR prototype insert can obtain dynamic images of small rodents at high activities ([Formula: see text] 500 MBq) with a high sensitivity and an excellent count-rate performance. Springer International Publishing 2022-06-13 /pmc/articles/PMC9192892/ /pubmed/35695989 http://dx.doi.org/10.1186/s40658-022-00454-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Khateri, Parisa
Lustermann, Werner
Ritzer, Christian
Tsoumpas, Charalampos
Dissertori, Günther
NEMA characterization of the SAFIR prototype PET insert
title NEMA characterization of the SAFIR prototype PET insert
title_full NEMA characterization of the SAFIR prototype PET insert
title_fullStr NEMA characterization of the SAFIR prototype PET insert
title_full_unstemmed NEMA characterization of the SAFIR prototype PET insert
title_short NEMA characterization of the SAFIR prototype PET insert
title_sort nema characterization of the safir prototype pet insert
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192892/
https://www.ncbi.nlm.nih.gov/pubmed/35695989
http://dx.doi.org/10.1186/s40658-022-00454-2
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