Cargando…

Combining metabolic phenotype determination with metabolomics and transcriptional analyses to reveal pathways regulated by hydroxycarboxylic acid receptor 2

BACKGROUND: The adaptation of cellular metabolism is considered a hallmark of cancer. Oncogenic signaling pathways support tumorigenesis and cancer progression through the induction of certain metabolic phenotypes associated with altered regulation of key metabolic enzymes. Hydroxycarboxylic acid re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rabe, Philipp, Gehmlich, Mareike, Peters, Anna, Krumbholz, Petra, Nordström, Anders, Stäubert, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192902/ https://www.ncbi.nlm.nih.gov/pubmed/35697980 http://dx.doi.org/10.1007/s12672-022-00503-3

Ejemplares similares

Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84
por: Peters, Anna, et al.
Publicado: (2020)

Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
por: Stäubert, Claudia, et al.
Publicado: (2015)

Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
por: Peters, Anna, et al.
Publicado: (2019)

Correction: Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
por: Peters, Anna, et al.
Publicado: (2019)

Protocol to characterize G(i/o) and G(s) protein-coupled receptors in transiently transfected cells using ELISA and cAMP measurements
por: Liebing, Aenne-Dorothea, et al.
Publicado: (2023)

Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules
por: Schulze, Amadeus Samuel, et al.
Publicado: (2022)

Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives
por: Ren, Qun, et al.
Publicado: (2010)

Chiroptical activity of hydroxycarboxylic acids with implications for the origin of biological homochirality
por: Bocková, Jana, et al.
Publicado: (2021)

Production of Hydroxycarboxylic Acid Receptor 3 (HCA(3)) Ligands by Bifidobacterium
por: Sakurai, Takuma, et al.
Publicado: (2021)

Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding
por: Suzuki, Shota, et al.
Publicado: (2023)

Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion
por: Buscemi, Lara, et al.
Publicado: (2021)

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2
por: Cheng, Lin, et al.
Publicado: (2023)

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
por: Pan, Xin, et al.
Publicado: (2023)

Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases
por: McGuire Sams, Cierla, et al.
Publicado: (2021)

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants
por: Vohra, Rupali, et al.
Publicado: (2022)

Study on the Hydration of α-Pinene Catalyzed by α-Hydroxycarboxylic Acid–Boric Acid Composite Catalysts
por: Meng, Zhonglei, et al.
Publicado: (2023)

Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells
por: Stäubert, Claudia, et al.
Publicado: (2015)

Integrated analyses reveal the response of peanut to phosphorus deficiency on phenotype, transcriptome and metabolome
por: Wu, Qi, et al.
Publicado: (2022)

Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from L-α-Amino Acids
por: Pickl, Mathias, et al.
Publicado: (2021)

Salt Shock Responses of Microcystis Revealed through Physiological, Transcript, and Metabolomic Analyses
por: Georges des Aulnois, Maxime, et al.
Publicado: (2020)

Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
por: Wang, Chun-Ying, et al.
Publicado: (2021)

Transcriptome and metabolome analyses reveal phenotype formation differences between russet and non-russet apples
por: Wang, Ziqi, et al.
Publicado: (2022)

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA(2))
por: Markovics, Arnold, et al.
Publicado: (2019)

Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors
por: Wellbourne-Wood, Joel, et al.
Publicado: (2022)

Enantioseparation of 3-Hydroxycarboxylic Acids via Diastereomeric Salt Formation by 2-Amino-1,2-diphenylethanol (ADPE) and Cinchonidine
por: Chandrasekaran, Srinivas, et al.
Publicado: (2022)

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation
por: Wannick, Melanie, et al.
Publicado: (2018)

Prenatal transcript levels and metabolomics analyses reveal metabolic changes associated with intrauterine growth restriction and sex
por: Ponsuksili, Siriluck, et al.
Publicado: (2022)

Transcriptome and metabolome analyses reveal transcription factors regulating ganoderic acid biosynthesis in Ganoderma lucidum development
por: Meng, Li, et al.
Publicado: (2022)

β-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis
por: Carretta, María D., et al.
Publicado: (2020)

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response
por: Parodi, Benedetta, et al.
Publicado: (2021)

Anodic oxidation triggered divergent 1,2- and 1,4-group transfer reactions of β-hydroxycarboxylic acids enabled by electrochemical regulation
por: Zhang, Zhenxing, et al.
Publicado: (2020)

Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer
por: Kerslake, Rachel, et al.
Publicado: (2022)

Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3‐Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects
por: Gopalasingam, Nigopan, et al.
Publicado: (2023)

Structural Speciation of Ti(IV)-(α-Hydroxycarboxylic Acid) Complexes in Metabolism-Related (Patho)Physiology—In Vitro Approaches to (Pre)Adipocyte Differentiation and Mineralization
por: Tsave, Olga, et al.
Publicado: (2023)

Transcriptome analyses reveal molecular mechanisms underlying phenotypic differences among transcriptional subtypes of glioblastoma
por: Pan, Yuan‐Bo, et al.
Publicado: (2020)

Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations
por: Auwerx, Chiara, et al.
Publicado: (2023)

Metabolomic and Transcriptomic Analyses Reveal That a MADS-Box Transcription Factor TDR4 Regulates Tomato Fruit Quality
por: Zhao, Xiaodan, et al.
Publicado: (2019)

Primary Investigation of Phenotypic Plasticity in Fritillaria cirrhosa Based on Metabolome and Transcriptome Analyses
por: Wang, Ye, et al.
Publicado: (2022)

Metagenomic and targeted metabolomic analyses reveal distinct phenotypes of the gut microbiota in patients with colorectal cancer and type 2 diabetes mellitus
por: Yang, Yong, et al.
Publicado: (2023)

Catch the wave: Metabolomic analyses in human pathogenic fungi
por: Brandt, Philipp, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kl1p3t78hic03jhm7igl1u91m3