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Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital

OBJECTIVES: Interpretation discrepancy is a major disadvantage of breast imaging. This study aimed to determine the clinical benefit of the pre-biopsy second-look breast ultrasound (US). METHODS: Patients with suspicious breast masses referred to our tertiary hospital for US-guided breast biopsy wer...

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Autores principales: Ma, Li, Qin, Jing, Kong, Lingyan, Zhao, Jialin, Xiao, Mengsu, Wang, Hongyan, Zhang, Jing, Jiang, Yuxin, Li, Jianchu, Liu, He, Zhu, Qingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192959/
https://www.ncbi.nlm.nih.gov/pubmed/35712464
http://dx.doi.org/10.3389/fonc.2022.901757
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author Ma, Li
Qin, Jing
Kong, Lingyan
Zhao, Jialin
Xiao, Mengsu
Wang, Hongyan
Zhang, Jing
Jiang, Yuxin
Li, Jianchu
Liu, He
Zhu, Qingli
author_facet Ma, Li
Qin, Jing
Kong, Lingyan
Zhao, Jialin
Xiao, Mengsu
Wang, Hongyan
Zhang, Jing
Jiang, Yuxin
Li, Jianchu
Liu, He
Zhu, Qingli
author_sort Ma, Li
collection PubMed
description OBJECTIVES: Interpretation discrepancy is a major disadvantage of breast imaging. This study aimed to determine the clinical benefit of the pre-biopsy second-look breast ultrasound (US). METHODS: Patients with suspicious breast masses referred to our tertiary hospital for US-guided breast biopsy were retrospectively reviewed between August 2017 and November 2019. Here, second-look assessments were performed by experienced specialized breast radiologists via performing a bilateral breast US scan plus reviewing former imaging studies, and results were compared with the initial assessment. Interpretation changes in terms of biopsy recommendation and surgical management (i.e., lumpectomy to mastectomy) were analyzed. RESULTS: A total of 537 patients were enrolled in this study. Interpretation discrepancies occurred in 109 patients (20%; 95% CI, 17%–24%). Among them, there were 84 patients (16%; 95% CI, 13%–19%) whose masses were re-classified as BI-RADS 3 by the second-look US and underwent 2-year follow-up, showing 82 benign, 1 malignant, and 1 high-risk lesions. On the other hand, 16 patients (3%; 95% CI, 2%–5%) undertook biopsy at an additional site, identifying 10 new malignant lesions, 3 high-risk lesions, and 3 benign lesions, resulting in surgical management changes in 12 patients. In addition, nine (2%; 95% CI, 1%–3%) patients received discrepant disease ranges, which also altered surgical management. Overall, 21 patients (4%; 95% CI, 3%–6%) got their surgical management altered by the second-look US. CONCLUSION: Pre-biopsy second-look assessment of breast US can reduce unnecessary biopsies in 16% of patients and alter surgical management in 4% of patients, suggesting it is a practical and valuable method for patient care improvement.
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spelling pubmed-91929592022-06-15 Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital Ma, Li Qin, Jing Kong, Lingyan Zhao, Jialin Xiao, Mengsu Wang, Hongyan Zhang, Jing Jiang, Yuxin Li, Jianchu Liu, He Zhu, Qingli Front Oncol Oncology OBJECTIVES: Interpretation discrepancy is a major disadvantage of breast imaging. This study aimed to determine the clinical benefit of the pre-biopsy second-look breast ultrasound (US). METHODS: Patients with suspicious breast masses referred to our tertiary hospital for US-guided breast biopsy were retrospectively reviewed between August 2017 and November 2019. Here, second-look assessments were performed by experienced specialized breast radiologists via performing a bilateral breast US scan plus reviewing former imaging studies, and results were compared with the initial assessment. Interpretation changes in terms of biopsy recommendation and surgical management (i.e., lumpectomy to mastectomy) were analyzed. RESULTS: A total of 537 patients were enrolled in this study. Interpretation discrepancies occurred in 109 patients (20%; 95% CI, 17%–24%). Among them, there were 84 patients (16%; 95% CI, 13%–19%) whose masses were re-classified as BI-RADS 3 by the second-look US and underwent 2-year follow-up, showing 82 benign, 1 malignant, and 1 high-risk lesions. On the other hand, 16 patients (3%; 95% CI, 2%–5%) undertook biopsy at an additional site, identifying 10 new malignant lesions, 3 high-risk lesions, and 3 benign lesions, resulting in surgical management changes in 12 patients. In addition, nine (2%; 95% CI, 1%–3%) patients received discrepant disease ranges, which also altered surgical management. Overall, 21 patients (4%; 95% CI, 3%–6%) got their surgical management altered by the second-look US. CONCLUSION: Pre-biopsy second-look assessment of breast US can reduce unnecessary biopsies in 16% of patients and alter surgical management in 4% of patients, suggesting it is a practical and valuable method for patient care improvement. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9192959/ /pubmed/35712464 http://dx.doi.org/10.3389/fonc.2022.901757 Text en Copyright © 2022 Ma, Qin, Kong, Zhao, Xiao, Wang, Zhang, Jiang, Li, Liu and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ma, Li
Qin, Jing
Kong, Lingyan
Zhao, Jialin
Xiao, Mengsu
Wang, Hongyan
Zhang, Jing
Jiang, Yuxin
Li, Jianchu
Liu, He
Zhu, Qingli
Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
title Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
title_full Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
title_fullStr Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
title_full_unstemmed Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
title_short Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
title_sort can pre-biopsy second-look breast ultrasound affect clinical management? experience from a single tertiary hospital
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192959/
https://www.ncbi.nlm.nih.gov/pubmed/35712464
http://dx.doi.org/10.3389/fonc.2022.901757
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