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Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital
OBJECTIVES: Interpretation discrepancy is a major disadvantage of breast imaging. This study aimed to determine the clinical benefit of the pre-biopsy second-look breast ultrasound (US). METHODS: Patients with suspicious breast masses referred to our tertiary hospital for US-guided breast biopsy wer...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192959/ https://www.ncbi.nlm.nih.gov/pubmed/35712464 http://dx.doi.org/10.3389/fonc.2022.901757 |
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author | Ma, Li Qin, Jing Kong, Lingyan Zhao, Jialin Xiao, Mengsu Wang, Hongyan Zhang, Jing Jiang, Yuxin Li, Jianchu Liu, He Zhu, Qingli |
author_facet | Ma, Li Qin, Jing Kong, Lingyan Zhao, Jialin Xiao, Mengsu Wang, Hongyan Zhang, Jing Jiang, Yuxin Li, Jianchu Liu, He Zhu, Qingli |
author_sort | Ma, Li |
collection | PubMed |
description | OBJECTIVES: Interpretation discrepancy is a major disadvantage of breast imaging. This study aimed to determine the clinical benefit of the pre-biopsy second-look breast ultrasound (US). METHODS: Patients with suspicious breast masses referred to our tertiary hospital for US-guided breast biopsy were retrospectively reviewed between August 2017 and November 2019. Here, second-look assessments were performed by experienced specialized breast radiologists via performing a bilateral breast US scan plus reviewing former imaging studies, and results were compared with the initial assessment. Interpretation changes in terms of biopsy recommendation and surgical management (i.e., lumpectomy to mastectomy) were analyzed. RESULTS: A total of 537 patients were enrolled in this study. Interpretation discrepancies occurred in 109 patients (20%; 95% CI, 17%–24%). Among them, there were 84 patients (16%; 95% CI, 13%–19%) whose masses were re-classified as BI-RADS 3 by the second-look US and underwent 2-year follow-up, showing 82 benign, 1 malignant, and 1 high-risk lesions. On the other hand, 16 patients (3%; 95% CI, 2%–5%) undertook biopsy at an additional site, identifying 10 new malignant lesions, 3 high-risk lesions, and 3 benign lesions, resulting in surgical management changes in 12 patients. In addition, nine (2%; 95% CI, 1%–3%) patients received discrepant disease ranges, which also altered surgical management. Overall, 21 patients (4%; 95% CI, 3%–6%) got their surgical management altered by the second-look US. CONCLUSION: Pre-biopsy second-look assessment of breast US can reduce unnecessary biopsies in 16% of patients and alter surgical management in 4% of patients, suggesting it is a practical and valuable method for patient care improvement. |
format | Online Article Text |
id | pubmed-9192959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91929592022-06-15 Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital Ma, Li Qin, Jing Kong, Lingyan Zhao, Jialin Xiao, Mengsu Wang, Hongyan Zhang, Jing Jiang, Yuxin Li, Jianchu Liu, He Zhu, Qingli Front Oncol Oncology OBJECTIVES: Interpretation discrepancy is a major disadvantage of breast imaging. This study aimed to determine the clinical benefit of the pre-biopsy second-look breast ultrasound (US). METHODS: Patients with suspicious breast masses referred to our tertiary hospital for US-guided breast biopsy were retrospectively reviewed between August 2017 and November 2019. Here, second-look assessments were performed by experienced specialized breast radiologists via performing a bilateral breast US scan plus reviewing former imaging studies, and results were compared with the initial assessment. Interpretation changes in terms of biopsy recommendation and surgical management (i.e., lumpectomy to mastectomy) were analyzed. RESULTS: A total of 537 patients were enrolled in this study. Interpretation discrepancies occurred in 109 patients (20%; 95% CI, 17%–24%). Among them, there were 84 patients (16%; 95% CI, 13%–19%) whose masses were re-classified as BI-RADS 3 by the second-look US and underwent 2-year follow-up, showing 82 benign, 1 malignant, and 1 high-risk lesions. On the other hand, 16 patients (3%; 95% CI, 2%–5%) undertook biopsy at an additional site, identifying 10 new malignant lesions, 3 high-risk lesions, and 3 benign lesions, resulting in surgical management changes in 12 patients. In addition, nine (2%; 95% CI, 1%–3%) patients received discrepant disease ranges, which also altered surgical management. Overall, 21 patients (4%; 95% CI, 3%–6%) got their surgical management altered by the second-look US. CONCLUSION: Pre-biopsy second-look assessment of breast US can reduce unnecessary biopsies in 16% of patients and alter surgical management in 4% of patients, suggesting it is a practical and valuable method for patient care improvement. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9192959/ /pubmed/35712464 http://dx.doi.org/10.3389/fonc.2022.901757 Text en Copyright © 2022 Ma, Qin, Kong, Zhao, Xiao, Wang, Zhang, Jiang, Li, Liu and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Ma, Li Qin, Jing Kong, Lingyan Zhao, Jialin Xiao, Mengsu Wang, Hongyan Zhang, Jing Jiang, Yuxin Li, Jianchu Liu, He Zhu, Qingli Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital |
title | Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital |
title_full | Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital |
title_fullStr | Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital |
title_full_unstemmed | Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital |
title_short | Can Pre-biopsy Second-Look Breast Ultrasound Affect Clinical Management? Experience From a Single Tertiary Hospital |
title_sort | can pre-biopsy second-look breast ultrasound affect clinical management? experience from a single tertiary hospital |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192959/ https://www.ncbi.nlm.nih.gov/pubmed/35712464 http://dx.doi.org/10.3389/fonc.2022.901757 |
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