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The antibody-binding Fc gamma receptor IIIa / CD16a is N-glycosylated with high occupancy at all five sites

The antibody-binding Fc γ receptors (FcγRs) trigger life-saving immune responses and many therapeutic monoclonal antibodies require FcγR engagement for full effect. One proven strategy to improve the efficacy of antibody therapies is to increase receptor binding affinity, in particular binding to Fc...

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Detalles Bibliográficos
Autores principales:	Lampros, Elizabeth A., Kremer, Paul G., Aguilar Díaz de León, Jesús S., Roberts, Elijah T., Rodriguez Benavente, Maria Carolina, Amster, I. Jonathan, Barb, Adam W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193405/ https://www.ncbi.nlm.nih.gov/pubmed/35712026 http://dx.doi.org/10.1016/j.crimmu.2022.05.005

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