The Association of Salivary Serotonin With Mood and Cardio-Autonomic Function: A Preliminary Report

BACKGROUND: Serotonin plays an important role in mood regulation and depression. However, it is not clear whether the levels of serotonin in saliva are related to current mood. AIM: To test the association of salivary serotonin concentrations with mood, as well as cardiovascular and autonomic parame...

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Detalles Bibliográficos
Autores principales: Karbownik, Michał Seweryn, Hicks, Steven Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193578/
https://www.ncbi.nlm.nih.gov/pubmed/35711584
http://dx.doi.org/10.3389/fpsyt.2022.788153
Descripción
Sumario:BACKGROUND: Serotonin plays an important role in mood regulation and depression. However, it is not clear whether the levels of serotonin in saliva are related to current mood. AIM: To test the association of salivary serotonin concentrations with mood, as well as cardiovascular and autonomic parameters. MATERIALS AND METHODS: Saliva samples were obtained from collegiate runners and output parameters were examined before and after physical activity. RESULTS: Salivary serotonin concentration was negatively associated with current mood (β = −0.32, 95%CI −0.62 to −0.02, p = 0.037, analysis adjusted for potential confounders), but insignificantly with measured cardiovascular and autonomic parameters. CONCLUSIONS: Salivary serotonin may reflect current mood. The results are preliminary and require further evaluation.

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